Evidence map›Paper›PMID 35084330›Full record

ArticleeLife2022

Adaptation of the periplasm to maintain spatial constraints essential for cell envelope processes and cell viability.

Eric Mandela, Christopher J Stubenrauch, David Ryoo, Hyea Hwang, Eli J Cohen, Von L Torres, Pankaj Deo, Chaille T Webb, Cheng Huang, Ralf B Schittenhelm and 4 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 4 countries.

Eric Mandela *Infection & Immunity Program, Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, Australia.
Christopher J Stubenrauch *Infection & Immunity Program, Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, Australia.ORCID 0000-0003-4388-3184
David RyooInterdisciplinary Bioengineering Graduate Program, Georgia Institute of Technology, Atlanta, United States.
Hyea HwangSchool of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, United States.
Eli J CohenDepartment of Life Sciences, Imperial College London, London, United Kingdom.
Von L TorresInfection & Immunity Program, Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, Australia.ORCID 0000-0003-3387-1112
Pankaj DeoInfection & Immunity Program, Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, Australia.ORCID 0000-0002-6947-5317
Chaille T WebbInfection & Immunity Program, Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, Australia.
Cheng HuangMonash Proteomics & Metabolomics Facility, Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Australia.
Ralf B SchittenhelmMonash Proteomics & Metabolomics Facility, Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Australia.
Morgan BeebyDepartment of Life Sciences, Imperial College London, London, United Kingdom.ORCID 0000-0001-6413-9835
J C GumbartSchool of Physics, Georgia Institute of Technology, Atlanta, United States.ORCID 0000-0002-1510-7842
Trevor LithgowInfection & Immunity Program, Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, Australia.
Iain D HaySchool of Biological Sciences, The University of Auckland, Auckland, New Zealand.ORCID 0000-0001-8797-6038
Discovery Institute · USGeorgia Institute of Technology · USImperial College London · GBUniversity of Auckland · NZ

Funding

Transport across two membranes by AcrAB-TolC complexR01AI052293 · NIAID · UNIVERSITY OF OKLAHOMA NORMAN · PI ZGURSKAYA, HELEN I · 2003 to 2024
$7.7M
Dynamic characterization of outer-membrane-protein biogenesis by the BAM and TAM complexesR01GM123169 · NIGMS · GEORGIA INSTITUTE OF TECHNOLOGY · PI GUMBART, JAMES C. · 2017 to 2021
$1.4M
NIAID NIH HHS R01 AI052293NIGMS NIH HHS R01 GM123169
6 · The paper itself

Abstract

The cell envelope of Gram-negative bacteria consists of two membranes surrounding a periplasm and peptidoglycan layer. Molecular machines spanning the cell envelope depend on spatial constraints and load-bearing forces across the cell envelope and surface. The mechanisms dictating spatial constraints across the cell envelope remain incompletely defined. In

Indexed as

Bacterial Outer Membrane ProteinsCell MembraneCell SurvivalCell WallEscherichia coliEscherichia coli ProteinsGram-Negative BacteriaLipoproteinsPeptidoglycanPeriplasmProtein TransportBacterial Outer Membrane ProteinsEscherichia coli ProteinsLipoproteinsLpp protein, E coliPeptidoglycancell biologycell envelopeE. coliinfectious diseaseLppmicrobiologypeptidoglycanperiplasm

Identifiers

PMID35084330
PMCPMC8824477
OpenAlexW4210620501

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.