ArticleJournal of the American Chemical Society2022
A Perspective on Late-Stage Aromatic C-H Bond Functionalization.
Article in Journal of the American Chemical Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.
What it found
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Who cites it
81 citing papers in PubMed, 298 citations in OpenAlex.
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- Electrophilic and Radical Ability of Organic Nitrating Reagents.The Journal of organic chemistry · 2026Article
- Pd-catalyzed sequential distal C-H alkenylation and π-allylic amination of arylacetic acids using MBH acetates: access to macrocyclic lactams.Chemical science · 2026Article
- Electrochemical oxidation enables aromatic C-H amination with dual mechanisms.Nature synthesis · 2026Article
- Biomimetic Mn(III) porphyrin-catalyzed aromaticity-breaking epoxidation of electron-deficient naphthalene.Nature communications · 2025Article
- Visible-light promoted late-stage chlorination and bromination of quinones and (hetero)arenes utilizing aqueous HCl or HBr as halogen donors.Communications chemistry · 2025Article
- Iridium catalyzed regiodivergent functionalization of all three C-H bonds of arenes by a single ligand.Nature communications · 2025Article
- Iridium-Catalyzed Direct and Site-Selective C-H Heteroarylation, Alkenylation, and Alkylation of Indoles.The Journal of organic chemistry · 2025Article
- Electronic Activation Enables the Borylation of Alkyl C-H Bonds in Saturated Nitrogen Heterocycles.Journal of the American Chemical Society · 2025Article
- A Broadly Applicable Strategy to Aminate Azines Enabled by Electronically Tuned Phosphine Reagents.Angewandte Chemie (International ed. in English) · 2025Article
- Late-stage-functionalization of anti-depressant molecule buspirone.Molecular diversity · 2025Review
- A selenoxide for single-atom protein modification of tyrosine residues enabled by water-resistant chalcogen and hydrogen bonding.Nature chemistry · 2025Article
- Modular alkyl growth in amines via the selective insertion of alkynes into C-C bonds.Nature chemistry · 2025Article
- Synthesis of diverse terpenoid frameworks via enzyme-enabled abiotic scaffold hop.Nature chemistry · 2025Article
- Predictable C-H Functionalization of ComplexACS central science · 2025Article
- Solventless Catalytic C-H and C-X Functionalization without Ball Milling.The Journal of organic chemistry · 2025Article
21 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Late-stage functionalization of C-H bonds (C-H LSF) can provide a straightforward approach to the efficient synthesis of functionalized complex molecules. However, C-H LSF is challenging because the C-H bond must be functionalized in the presence of various other functional groups. In this Perspective, we evaluate aromatic C-H LSF on the basis of four criteria─reactivity, chemoselectivity, site-selectivity, and substrate scope─and provide our own views on current challenges as well as promising strategies and areas of growth going forward.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.