Evidence map›Paper›PMID 35083929›Full record

ArticleJournal of the American Heart Association2022

Sex-Specific Temporal Trends in Hypertensive Crisis Hospitalizations in the United States.

Joseph E Ebinger, Yunxian Liu, Matthew Driver, Hongwei Ji, C Noel Bairey Merz, Florian Rader, Christine M Albert, Susan Cheng

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Observational
  2. Observational
  3. Brazilian Guidelines of Hypertension - 2025.Arquivos brasileiros de cardiologia · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Joseph E EbingerDepartment of Cardiology Smidt Heart InstituteCedars-Sinai Medical Center Los Angeles CA.ORCID 0000-0002-0587-1572
Yunxian LiuDepartment of Cardiology Smidt Heart InstituteCedars-Sinai Medical Center Los Angeles CA.ORCID 0000-0002-3570-103X
Matthew DriverDepartment of Cardiology Smidt Heart InstituteCedars-Sinai Medical Center Los Angeles CA.ORCID 0000-0002-5389-1148
Hongwei JiDepartment of Cardiology The Affiliated Hospital of Qingdao University Qingdao Shandong China.ORCID 0000-0003-3657-4666
C Noel Bairey MerzDepartment of Cardiology Smidt Heart InstituteCedars-Sinai Medical Center Los Angeles CA.ORCID 0000-0002-9933-5155
Florian RaderDepartment of Cardiology Smidt Heart InstituteCedars-Sinai Medical Center Los Angeles CA.ORCID 0000-0003-1637-5096
Christine M AlbertDepartment of Cardiology Smidt Heart InstituteCedars-Sinai Medical Center Los Angeles CA.ORCID 0000-0002-2081-1121
Susan ChengDepartment of Cardiology Smidt Heart InstituteCedars-Sinai Medical Center Los Angeles CA.ORCID 0000-0002-4977-036X
Cedars-Sinai Medical Center · USQingdao University · CN

Funding

Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
The Microvascular Aging and Eicosanoids - Women's Evaluation of Systemic Aging Tenacity (MAE-WEST) ("You are never too old to become younger!") Specialized Center for Research Excellence (SCORE)U54AG065141 · NIA · CEDARS-SINAI MEDICAL CENTER · PI BAIREY MERZ, CATHLEEN NOEL, CHENG, SUSAN · 2020 to 2024
$8.7M
Barber-Pharmacist Coordination to Improve Blood Pressure Management in Black MenR01HL117983 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI ALBERT, CHRISTINE M · 2014 to 2018
$8.6M
Cardiac microstructure and the immune-inflammatory response to SARS-CoV-2R01HL131532 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI CHENG, SUSAN, LI, DEBIAO · 2016 to 2025
$6.6M
Women's Ischemia Syndrome Evaluation (WISE) - Mechanisms of Coronary Microvascular Dysfunction Leading to Pre-Heart Failure with Preserved Ejection Fraction (HFpEF)R01HL146158 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI BAIREY MERZ, CATHLEEN NOEL · 2019 to 2023
$3.7M
Mediators of Systemic Inflammation and Heart Failure Risk in the CommunityR01HL143227 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI CHENG, SUSAN · 2019 to 2022
$3.3M
Ventricular-vascular coupling in the elderly: lifecourse determinants, trajectories, and prognostic significanceR01HL142983 · NHLBI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CHENG, SUSAN, MITCHELL, GARY FRANK · 2019 to 2022
$3.2M
Inflammatory Mediators, Cardiovascular Health, and Longevity in WomenR01HL134168 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI CHENG, SUSAN · 2016 to 2019
$1.6M
Implementation Science to Improve Cardiovascular Health: Leveraging EHR Systems to Advance Care of Resistant HypertensionK23HL153888 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI EBINGER, JOSEPH · 2020 to 2024
$929k
NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1 TR001881NHLBI NIH HHS K23 HL153888NHLBI NIH HHS R01 HL117983NHLBI NIH HHS R01 HL131532NHLBI NIH HHS R01 HL134168NHLBI NIH HHS R01 HL142983NHLBI NIH HHS R01 HL143227NHLBI NIH HHS R01 HL146158NIA NIH HHS U54 AG065141NIH HHS P51 OD011132
6 · The paper itself

Abstract

Background Despite recent improvements in hypertension control overall, the extent to which these trends apply to the most extreme forms of elevated blood pressure-hypertensive crises requiring hospitalization-in both women and men at risk remains unknown. Methods and Results Using data from the National Inpatient Sample, we estimated sex-pooled and sex-specific temporal trends in hypertensive crisis hospitalization and case fatality rates over serial time periods: years 2002 to 2006, 2007 to 2011, and 2012 to 2014. Over the entire study period (years 2002-2014), there were an estimated 918 392±9331 hypertensive crisis hospitalizations and 4377±157 in-hospital deaths. Hypertensive crisis represented 0.23%±0.002% of all hospitalizations during the entire study period: 0.24%±0.002% for men and 0.22%±0.002% for women. In multivariable analyses adjusting for age, race or ethnicity, and cardiovascular conditions, the odds of experiencing a hospitalization primarily for hypertensive crisis increased annually for both men (odds ratio [OR], 1.083 per year; 95% CI, 1.08-1.09) and women (OR, 1.07 per year, 95% CI, 1.07-1.08) with a higher rate of increase observed in men compared with women (

Indexed as

HospitalizationHypertensionEthnicityFemaleHumansMaleOdds RatioUnited Stateshypertensionhypertensive crisissex differences

Identifiers

PMID35083929
PMCPMC9245827
OpenAlexW4210305877

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.