Evidence map›Paper›PMID 35083901›Full record

ArticleYonsei medical journal2022

The Immunomodulating Effects of Thalidomide and Dexamethasone in a Murine Cardiac Allograft Transplantation Model.

Soo Jin Kim, Joon Ye Kim, Eun Jee Kim, Hyojung Lee, Yuri Cho, Myoung Soo Kim, Yu Seun Kim, Beom Seok Kim, Kyu Ha Huh

Open access · goldAbstract read
In one paragraph

Article in Yonsei medical journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Soo Jin Kim *Department of Surgery, Yonsei University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-5576-8557
Joon Ye Kim *The Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-1180-2899
Eun Jee KimThe Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-3027-2571
Hyojung LeeThe Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0003-3110-3718
Yuri ChoThe Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0001-8805-4975
Myoung Soo KimDepartment of Surgery, Yonsei University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-8975-8381
Yu Seun KimDepartment of Surgery, Yonsei University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-5105-1567
Beom Seok KimThe Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-5732-2583
Kyu Ha HuhDepartment of Surgery, Yonsei University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0003-1364-6989
Yonsei University · KR

Funding

Korea Health Industry Development Institute HI18C0629
6 · The paper itself

Abstract

purposeThe immunomodulatory effects of thalidomide (TM) and dexamethasone (DX) on immune cells and their co-stimulatory, co-inhibitory molecules in vitro and in vivo have been previously reported. The current study investigated the effects of TM and the combinatorial treatment with DX on immune cells using a murine cardiac allograft transplantation model. MATERIALS AND

methodsIntraabdominal transplant of cardiac allografts from BALB/c (H-2

resultsThe mean graft survivals were 6.86 days in the untreated group, and 10.0 days in the TM/DX group (

conclusionThese outcomes suggest the immunomodulating effect of the TM/DX combinatorial treatment. In conclusion, TM/DX combination may be a promising immunomodulatory approach for preventing allograft rejection and improving graft survival by inducing tolerance in transplantation.

Indexed as

Leukocytes, MononuclearThalidomideAllograftsAnimalsDexamethasoneGraft RejectionGraft SurvivalMiceMice, Inbred C57BLT-Lymphocytes, RegulatoryDexamethasoneThalidomidecardiac transplantationdendritic cellsdexamethasoneImmunomodulationT cellsthalidomide

Identifiers

PMID35083901
PMCPMC8819408
OpenAlexW4210799921

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.