Evidence map›Paper›PMID 35083735›Full record

ArticleJournal of medical toxicology : official journal of the American College of Medical Toxicology2022

The Role of Echocardiographic Findings in Estimating Survival Probability of Intensive Care Unit Admitted Aluminum Phosphide Poisoned Patients.

Fatma M Elgazzar, Mohamed A Shama, Osama Shoeib, Amal S A F Hafez

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In one paragraph

Article in Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Fatma M ElgazzarForensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Medical Collages Complex, Tanta University, Al-Geesh Street, Tanta, 31527, Egypt. fatma.elgazar@med.tanta.edu.eg.ORCID 0000-0002-2353-9223
Mohamed A ShamaEmergency Medicine and Traumatology Department, Faculty of Medicine, Tanta University, Tanta, Egypt.ORCID 0000-0002-4083-4742
Osama ShoeibCardiology Department, Faculty of Medicine, Tanta University, Tanta, Egypt.ORCID 0000-0002-8161-1457
Amal S A F HafezForensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Medical Collages Complex, Tanta University, Al-Geesh Street, Tanta, 31527, Egypt.ORCID 0000-0002-7463-8416
Tanta University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionCardiotoxicity represents the primary cause of death in acute aluminum phosphide (AlP) poisoning. Prompt supportive care can improve patient survival. This study assessed the role of echocardiography in estimating the survival probability of AlP-poisoned patients admitted to the intensive care unit.

methodsA prospective cohort study of symptomatic acute AlP poisoned patients was conducted between September 2019 and December 2020. Patients were subjected to history taking, clinical examination, To be included, patient evaluation needed to include electrocardiographic (ECG) and echocardiographic studies. The statistical analysis assessed the association between patient survival and relevant factors. Survival analysis was performed using the Kaplan-Meier survival curve and Cox proportional hazard regression.

resultsA total of 90 patients met inclusion criteria. Electrocardiographic abnormalities were detected in 38.1% of survivors and 82.6% of non-survivors (p < 0.001). Survivors had a higher mean left ventricle ejection fraction (LVEF) (50.86 ± 6.30% vs. 26.52 ± 7.64%, respectively, p < 0.001) and a lower percentage of global LV hypokinesia (4.8% vs. 94.2%, p < 0.001). The mean survival time was higher among patients with LVEF ≥ 50% than those with LVEF = 41-49% and ≤ 40% (p = 0.014 and 0.001, respectively). The hazard of death was 4.42 and 5.40 times greater in patients with LVEF ≤ 40% or with global LV hypokinesia, respectively. Regression revealed that the global LV hypokinesia, ECG abnormalities, and decreased LVEF and oxygen saturation were significantly associated with the risk of death (hazard ratios: 4.382, 3.348, 0.957, and 0.971, respectively).

conclusionsEchocardiography represents a valuable diagnostic tool to assess cardiac function in acute AlP poisoning. Both LVEF and global LV hypokinesia significantly impact the survival of AlP-poisoned patients. Echocardiography was superior to ECG changes in terms of accuracy for the prediction of mortality.

Indexed as

PoisonsAluminum CompoundsArrhythmias, CardiacEchocardiographyHumansHypokinesiaIntensive Care UnitsPhosphinesProbabilityProspective StudiesAluminum Compoundsaluminum phosphidePhosphinesPoisonsAluminum phosphideCardiotoxicityEchocardiographyElectrocardiographySurvival

Identifiers

PMID35083735
PMCPMC8938530
OpenAlexW4210331371

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.