Trial reportProbiotics and antimicrobial proteins2022
Prevention of Recurrent Childhood Caries with Probiotic Supplements: A Randomized Controlled Trial with a 12-Month Follow-Up.
Trial report in Probiotics and antimicrobial proteins, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04929340 (Prevention of Recurrent Childhood Caries With Probiotic Supplement, a Randomized Controlled Trial), which is not on this map. Cited by 14 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prevention of Recurrent Childhood Caries With Probiotic Supplement, a Randomized Controlled Trial
Who cites it
14 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Probiotic supplementation and dental caries prevention in children and adolescents: a systematic review of strain-specific and context-dependent effects.Clinical oral investigations · 2026Pooled it
- Comparative effectiveness of probiotics, prebiotics, synbiotics, and postbiotics in preventing dental caries: a meta-analysis from an oral microbiota modulation perspective.BMC oral health · 2026Pooled it
- Effect of probiotic interventions on oral health in children: a systematic review.Frontiers in dental medicine · 2026Pooled it
- The role of probiotics in preventing dental caries: a systematic review of clinical evidence.Frontiers in oral health · 2025Pooled it
- Salivary immune alteration persists after caries treatment.Scientific reports · 2026Article
- Effects of Oral Probiotics onDentistry journal · 2026Review
- Oral hygiene agents at work: effects onFrontiers in cellular and infection microbiology · 2026Review
- The role of probiotics in modulating cariogenic bacteria and oral health outcomes: A systematic review and risk of bias assessment.The Saudi dental journal · 2025Review
- Natural Compounds in Oral Microbiota Modulation and Caries Prevention: A Systematic Review.Dentistry journal · 2025Review
- Serum level of TNF-a, IL-1 and IL-6 and serum biomarkers after nutritional change in patients' ventilator-associated pneumonia.Journal of medical biochemistry · 2025Article
- Dietary and complementary oral supplements for the management of chronic diseases in children: a systematic review.Frontiers in pediatrics · 2025Review
- Managing Early Childhood Caries: A Comparative Review of Preventive and Restorative Approaches.Cureus · 2024Review
- The Benefits of Probiotics on Oral Health: Systematic Review of the Literature.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Anti-caries Streptococcus spp.: A potential preventive tool for special needs patients.Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric DentistryReview
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to evaluate the effect of drops containing probiotic bacteria on the recurrence of dental caries in preschool children. The study employed a randomized, placebo-controlled, double-blinded design with two parallel arms. 38 preschool children were enrolled after comprehensive restorative treatment under general anesthesia or conscious sedation (baseline), and they were followed up after 6 and 12 months. Parents of children in the test group were instructed to give 5 daily drops containing two strains of Limosilactobacillus reuteri (DSM 17938 and ATCC PTA 5289) at bedtime. The placebo drops were identically composed but lacked bacteria. The duration of the intervention was 12 months. The primary endpoint was recurrence of new caries lesions on subject level (yes/no), and secondary endpoints were presence of dental plaque and gingivitis. We found high rate of recurrent moderate and extensive lesions after 12 months (67%) but there were no significant differences between the groups. We observed no beneficial effects on dental plaque or gingival inflammation. The findings were however uncertain and inconclusive due to lack of power, a consequence of the COVID-19 pandemic. ClinTrials.gov Identifier: (NCT04929340), June 18, 2021; retrospectively registered.
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