ArticleEnvironmental science and pollution research international2022
Echinops spinosus effect against diabetes and its hepatorenal complications: total extract and flavonoids fraction.
Article in Environmental science and pollution research international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Review
- Cocoa and Carob Supplementation, Alone or in Combination with Metformin, Protects against Hepatorenal Injury in Zucker Diabetic Fatty Rats.Nutrients · 2024Article
- Galangin: A Promising Flavonoid for the Treatment of Rheumatoid Arthritis-Mechanisms, Evidence, and Therapeutic Potential.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Nephroprotective Efficacy ofACS omega · 2023Article
- ExploringMolecules (Basel, Switzerland) · 2023Article
- Paliurus spina-christi Mill fruit extracts improve glucose uptake and activate the insulin signaling pathways in HepG2 insulin-resistant cells.BMC complementary medicine and therapies · 2023Article
- Lycopene Modulates Oxidative Stress and Inflammation in Hypercholesterolemic Rats.Pharmaceuticals (Basel, Switzerland) · 2022Article
- In Vivo Efficacy ofAnimals : an open access journal from MDPI · 2022Article
- Lycopene Effects on Metabolic Syndrome and Kidney Injury in Rats Fed a High-Fat Diet: An Experimental Study.ACS omega · 2022Article
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Authors and funding
7 authors.
Funding
Abstract
The perennial plant Echinops spinosus (ES) grows in the Hail area of Saudi Arabia, and its traditional formulations are often employed in folk medicine. The goal of this study is to identify the active components present in Hail Echinops spinosus and to investigate the anti-diabetic properties of both ES total extract (ESTE) and its high flavonoids fraction (ESHFF) in experimental diabetes induced by streptozotocin (STZ) injection in rats. Forty-two rats were divided into six groups. Diabetes was induced using STZ (55 mg/kg). Seven days after STZ administration, the diabetic animals were treated daily with ESTE, ESHFF, or metformin (MET) as a standard anti-diabetic drug for 28 days. Blood and tissues samples were collected for biochemical, molecular, and histological investigations. Both ESTE and ESHFF demonstrated anti-diabetic properties, as evidenced by lowering glucose levels and increasing the levels of insulin, insulin receptor expression rate, and glycogen synthesis. Additionally, ESTE as well as ESHFF alleviated diabetic complications in the kidneys and liver by decreasing oxidative stress, modulating inflammatory mediators, and suppressing the apoptotic cascade along with correcting diabetic dyslipidemia. It could be deduced that Hail ES extracts could play a role in the treatment of type 2 diabetes and diabetes-related lesions as well as oxidative damage in hepatic and renal tissues.
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Registered trials
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