ArticleJournal of neuro-oncology2022
Long term outcomes following surgery for pineal region tumors.
Article in Journal of neuro-oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- Stereotactic radiosurgery for pineal gland metastases: results from the international radiosurgery research foundation.Journal of neuro-oncology · 2026Article
- Multimodal, Personalized Treatment of Pineal Region Tumors in Adulthood-A Single Center Study.Journal of clinical medicine · 2025Article
- Concurrent surgical management of pineoblastoma and Chiari type 1.5 malformation: a case report.BMC surgery · 2025Article
- The comparison in postoperative complications and prognosis between pediatric and adult patients with pineal region tumors.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Article
- Machine learning decision support model construction for craniotomy approach of pineal region tumors based on MRI images.BMC medical imaging · 2025Article
- [Neurosurgical treatment of tumors of the pineal region - literature review and overview of cases at OMIII].Magyar onkologia · 2024Review
- Understanding and Managing Pineal Parenchymal Tumors of Intermediate Differentiation: An In-Depth Exploration from Pathology to Adjuvant Therapies.Journal of clinical medicine · 2024Review
- Capturing evolving definitions of 12 select rare CNS tumors: a timely report from CBTRUS and NCI-CONNECT.Journal of neuro-oncology · 2023Article
- The Use of the Suboccipital Transtentorial Approach to the Posterior Inferior Incisural Space.Cureus · 2023Article
- Pediatric pineal region masses: a single-center experience over 25 years.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023Article
- Optimal therapeutic strategies for pineal region lesions.Frontiers in neurology · 2023Article
- Review
- Evaluation of the Perioperative and Postoperative Course of Surgery for Pineal Germinoma in the SIOP CNS GCT 96 Trial.Cancers · 2022Article
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePineal region tumors are surgically demanding tumors to resect. Long term neuro-oncologic outcomes following surgical excision of tumors from this region have been underreported. We sought to define the long term outcomes of patients undergoing resection of pineal region tumors.
methodsA retrospective analysis of a prospectively maintained database was performed on patients who underwent intended surgical excision of pineal region tumors. Overall survival (OS) and progression free survival (PFS) were the primary endpoints of this study. Factors associated with OS, PFS and the degree of resection were analyzed, along with 30-day complication rates and dependence on CSF diversion.
resultsSixty-eight patients with a mean age of 30.9 ± 15.3 years were analyzed. The median clinical and radiographic follow-up was 95.7 and 48.2 months, respectively. The supracerebellar infratentorial and the occipital transtentorial corridors were utilized in the majority of cases (80.9%). The gross total resection (GTR) rate was 52.9% (n=36). The 5-year OS and PFS rates were 70.2% and 58.5%, respectively. Achieving GTR was associated with improved OS (HR 0.39, p = 0.03) and PFS (HR 0.4, p = 0.006). The 30-day mortality rate was 5.9%. The need for CSF diversion was high with 77.9% of patients requiring a shunt or ETV by last follow-up.
conclusionsThis is the first modern surgical series providing long term follow-up for patients undergoing surgical resection of pineal region tumors. Obtaining a GTR of these challenging tumors is beneficial with regards to PFS/OS. Higher grade tumors have diminished PFS/OS and are treated with adjuvant chemotherapy and/or radiotherapy.
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