Evidence map›Paper›PMID 35083468›Full record

ArticleCommunications medicine2021

Pathological manifestation of human endogenous retrovirus K in frontotemporal dementia.

Katherine Phan, Ying He, YuHong Fu, Nicolas Dzamko, Surabhi Bhatia, Julian Gold, Dominic Rowe, Yazi D Ke, Lars M Ittner, John R Hodges and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Human Endogenous Retrovirus K in Astrocytes Is Altered in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2025
    Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Retroviral Elements in Pathophysiology and as Therapeutic Targets for Amyotrophic Lateral Sclerosis.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022
    Review
  20. Role for endogenous retrovirus in FTD.Nature reviews. Neurology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Katherine PhanThe University of Sydney, Brain and Mind Centre, Sydney, NSW, Australia.
Ying HeThe University of Sydney, Brain and Mind Centre, Sydney, NSW, Australia.
YuHong FuThe University of Sydney, Brain and Mind Centre, Sydney, NSW, Australia.
Nicolas DzamkoThe University of Sydney, Brain and Mind Centre, Sydney, NSW, Australia.
Surabhi BhatiaThe University of Sydney, Brain and Mind Centre, Sydney, NSW, Australia.
Julian GoldThe University of Sydney, The Albion Centre, Sydney, NSW, Australia.
Dominic RoweFaculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, Australia.
Yazi D KeDementia Research Centre and Department of Biomedical Sciences, Macquarie University, Sydney, NSW, Australia.
Lars M IttnerDementia Research Centre and Department of Biomedical Sciences, Macquarie University, Sydney, NSW, Australia.
John R HodgesThe University of Sydney, Brain and Mind Centre, Sydney, NSW, Australia.
Olivier PiguetThe University of Sydney, Brain and Mind Centre, Sydney, NSW, Australia.
Matthew C KiernanThe University of Sydney, Brain and Mind Centre, Sydney, NSW, Australia.
Glenda M HallidayThe University of Sydney, Brain and Mind Centre, Sydney, NSW, Australia.
Woojin Scott KimThe University of Sydney, Brain and Mind Centre, Sydney, NSW, Australia.
The University of Sydney · AUMacquarie University · AU

Funding

Brain Tissue Resource Centre for Alcohol ResearchR28AA012725 · NIAAA · UNIVERSITY OF SYDNEY · PI Greg Trevor Sutherland · 2012 to 2026
$7.0M
NIAAA NIH HHS R28 AA012725
6 · The paper itself

Abstract

backgroundBehavioral variant frontotemporal dementia (bvFTD) is a common form of younger-onset dementia with a proportion of cases overlapping pathologically and genetically with amyotrophic lateral sclerosis (ALS). Previous studies have identified that the human endogenous retrovirus K (HERV-K) is elevated in ALS serum and is associated with ALS TDP-43 pathology. In contrast, little is known about HERV-K changes in bvFTD. Here, we investigated the possible role of HERV-K in bvFTD.

methodsWe measured the HERV-K

resultsHere, we show that HERV-K

conclusionsThese results suggest that manifestation of HERV-K is associated with bvFTD TDP-43 pathology. Analysis of HERV-K in bvFTD may provide insight into an unrecognized but targetable perturbed pathology.

Indexed as

amyotrophic lateral sclerosisbiomarkerbrainfrontotemporal dementiaHERV-KHERV-Whuman endogenous retrovirusmotor neuron diseaseserumTDP-43

Identifiers

PMID35083468
PMCPMC8788987
OpenAlexW4200505280

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.