ArticleAging pathobiology and therapeutics2020
QuPath. A new digital imaging tool for geropathology.
Article in Aging pathobiology and therapeutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Article
- LOGSAGE: LOG-BASED SALIENCY FOR GUIDED ENCODING IN ROBUST NUCLEI SEGMENTATION OF IMMUNOFLUORESCENCE HISTOLOGY IMAGES.Proceedings. IEEE International Symposium on Biomedical Imaging · 2025Article
- A cocktail of rapamycin, acarbose, and phenylbutyrate prevents age-related cognitive decline in mice by targeting multiple aging pathways.GeroScience · 2024Article
- Behavioral and neuropathological features of Alzheimer's disease are attenuated in 5xFAD mice treated with intranasal GHK peptide.Aging pathobiology and therapeutics · 2024Article
- Intranasal GHK peptide enhances resilience to cognitive decline in aging mice.bioRxiv : the preprint server for biology · 2023Article
- HLA-II-Dependent Neuroimmune Changes in Group A Streptococcal Necrotizing Fasciitis.Pathogens (Basel, Switzerland) · 2023Article
- Effects of Probiotics on Colitis-Induced Exacerbation of Alzheimer's Disease inInternational journal of molecular sciences · 2023Article
- Ovalbumin-specific CD4Frontiers in immunology · 2023Article
- A mouse model of naturally occurring age-related cognitive impairment.Aging pathobiology and therapeutics · 2022Article
- Resilience to acute sleep deprivation is associated with attenuation of hippocampal mediated learning impairment.Aging pathobiology and therapeutics · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Translational research regularly utilizes immunohistochemistry (IHC) to investigate pathological differences in the clinical or laboratory setting. However, the majority of these studies require the extensive work of a trained pathologist to analyze slides in a meaningful way. In order to explore new ways to quantitate IHC stains in a manner that is reproducible and efficient for both pathologists and research scientists, QuPath was explored as a new digital imaging tool. The hippocampal area of brains from older sleep deprived mice were stained using established IHC protocols to explore biomarker levels that would be insightful for measurable differences. Application features of QuPath are described that quantitatively show sleep deprived mice had robust differences in staining intensity for four different biomarkers compared to non-sleep deprived mice. These observations provide the rationale for QuPath as a digital imaging tool to enhance the quantitative and qualitative usefulness of IHC staining in the field of geropathology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.