Evidence map›Paper›PMID 35083342›Full record

ArticleJournal of immunology research2022

Peptidylarginine Deiminase 2 in Murine Antiviral and Autoimmune Antibody Responses.

Aisha M Mergaert, Michael F Denny, Brock Kingstad-Bakke, Mandar Bawadekar, S Janna Bashar, Thomas F Warner, Marulasiddappa Suresh, Miriam A Shelef

Open access · goldAbstract read
In one paragraph

Article in Journal of immunology research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Aisha M MergaertDepartment of Medicine, University of Wisconsin-Madison, Madison, WI, USA.ORCID https://orcid.org/0000-0002-8177-9161
Michael F DennyDepartment of Medicine, University of Wisconsin-Madison, Madison, WI, USA.
Brock Kingstad-BakkeDepartment of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USA.
Mandar BawadekarDepartment of Medicine, University of Wisconsin-Madison, Madison, WI, USA.
S Janna BasharDepartment of Medicine, University of Wisconsin-Madison, Madison, WI, USA.
Thomas F WarnerDepartment of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI, USA.
Marulasiddappa SureshDepartment of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USA.ORCID https://orcid.org/0000-0003-1794-3358
Miriam A ShelefDepartment of Medicine, University of Wisconsin-Madison, Madison, WI, USA.ORCID https://orcid.org/0000-0002-8842-0303
University of Wisconsin–Madison · US

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Christian Capitini · 1985 to 2026
$142.6M
RESEARCH TRAINING IN HEMATOLOGYT32HL007899 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI Jane Ellen Churpek · 1998 to 2026
$8.2M
Novel Combination Adjuvant for Eliciting Systemic and Mucosal CD8 T Cell MemoryU01AI124299 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI KLEIN, BRUCE STEVEN, SURESH, MARULASIDDAPPA · 2016 to 2025
$6.2M
Mucosal Adjuvant to Induce Multipronged T Cell Immunity to TuberculosisR21AI149793 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI SURESH, MARULASIDDAPPA · 2020 to 2021
$427k
NCI NIH HHS P30 CA014520NHLBI NIH HHS T32 HL007899NIAID NIH HHS R21 AI149793NIAID NIH HHS U01 AI124299
6 · The paper itself

Abstract

The peptidylarginine deiminases (PADs) and the citrullinated proteins that they generate have key roles in innate immunity and rheumatoid arthritis, an inflammatory arthritis with antibodies that target citrullinated proteins. However, the importance of PADs, particularly PAD2, in the adaptive immune response, both normal and pathogenic, is newly emerging. In this study, we evaluated a requirement for PAD2 in the antibody response in collagen-induced arthritis (CIA), a T and B cell-driven murine model of rheumatoid arthritis, and in the protective antibody response to murine influenza infection. Using PAD2

Indexed as

Adaptive ImmunityAnimalsAntibody FormationAnti-Citrullinated Protein AntibodiesAntiviral AgentsArthritis, ExperimentalArthritis, RheumatoidAutoantibodiesCitrullinationHumansHydrolasesImmunity, InnateMiceMice, Inbred DBAProtein-Arginine Deiminase Type 2Anti-Citrullinated Protein AntibodiesAntiviral AgentsAutoantibodiesHydrolasesPADI2 protein, humanProtein-Arginine Deiminase Type 2

Identifiers

PMID35083342
PMCPMC8786467
OpenAlexW4205760175

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.