Evidence map›Paper›PMID 35083324›Full record

ArticleERJ open research2022

Evidence for shared genetic risk factors between lymphangioleiomyomatosis and pulmonary function.

Xavier Farré, Roderic Espín, Alexandra Baiges, Eline Blommaert, Wonji Kim, Krinio Giannikou, Carmen Herranz, Antonio Román, Berta Sáez, Álvaro Casanova and 16 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ERJ open research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 10 institutions in 4 countries.

Xavier FarréGenomes for Life - GCAT Lab Group, Institut Germans Trias i Pujol, Badalona, Spain.
Roderic EspínProCURE, Catalan Institute of Oncology, Oncobell, Bellvitge Institute for Biomedical Research (IDIBELL), Barcelona, Spain.
Alexandra BaigesProCURE, Catalan Institute of Oncology, Oncobell, Bellvitge Institute for Biomedical Research (IDIBELL), Barcelona, Spain.
Eline BlommaertProCURE, Catalan Institute of Oncology, Oncobell, Bellvitge Institute for Biomedical Research (IDIBELL), Barcelona, Spain.
Wonji KimChanning Division of Network Medicine, Dept of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Krinio GiannikouCancer Genetics Laboratory, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Carmen HerranzProCURE, Catalan Institute of Oncology, Oncobell, Bellvitge Institute for Biomedical Research (IDIBELL), Barcelona, Spain.
Antonio RománLung Transplant Unit, Pneumology Service, Lymphangioleiomyomatosis Clinic, Vall d'Hebron University Hospital, Vall d'Hebron Research Institute (VHIR), Barcelona, Spain.
Berta SáezLung Transplant Unit, Pneumology Service, Lymphangioleiomyomatosis Clinic, Vall d'Hebron University Hospital, Vall d'Hebron Research Institute (VHIR), Barcelona, Spain.
Álvaro CasanovaPneumology Service, University Hospital of Henares, University Francisco de Vitoria, Coslada, Spain.
Julio AncocheaPneumology Service, La Princesa Research Institute, University Hospital La Princesa, Madrid, Spain.
Claudia ValenzuelaPneumology Service, La Princesa Research Institute, University Hospital La Princesa, Madrid, Spain.
Piedad UssettiPneumology Service, University Hospital Clinica Puerta del Hierro, Majadahonda, Spain.
Rosalía LaportaPneumology Service, University Hospital Clinica Puerta del Hierro, Majadahonda, Spain.
José A Rodríguez-PortalMedical-Surgical Unit of Respiratory Diseases, University Hospital Virgen del Rocío, Institute of Biomedicine of Seville (IBiS), Seville, Spain.
Coline H M van MoorselInterstitial Lung Disease Center of Excellence, St Antonius Hospital, Nieuwegein, The Netherlands.
Joanne J van der VisInterstitial Lung Disease Center of Excellence, St Antonius Hospital, Nieuwegein, The Netherlands.
Marian J R QuanjelInterstitial Lung Disease Center of Excellence, St Antonius Hospital, Nieuwegein, The Netherlands.ORCID https://orcid.org/0000-0002-0460-8641
Mireia Tena-GaritaonaindiaDept of Biochemistry and Molecular Biology II, School of Pharmacy, Instituto de Investigación Biosanitaria (ibs.GRANADA), University of Granada, Granada, Spain.
Fermín Sánchez de MedinaBiomedical Research Network Centre in Hepatic and Digestive Diseases (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain.
Francesca MateoProCURE, Catalan Institute of Oncology, Oncobell, Bellvitge Institute for Biomedical Research (IDIBELL), Barcelona, Spain.
María Molina-MolinaBiomedical Research Network Centre in Respiratory Diseases (CIBERES), Instituto de Salud Carlos III, Madrid, Spain.
Sungho WonDept of Public Health Sciences, Interdisciplinary Program of Bioinformatics, Institute of Health and Environment, Seoul National University, Seoul, South Korea.
David J KwiatkowskiCancer Genetics Laboratory, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Rafael de CidGenomes for Life - GCAT Lab Group, Institut Germans Trias i Pujol, Badalona, Spain.
Miquel Angel PujanaProCURE, Catalan Institute of Oncology, Oncobell, Bellvitge Institute for Biomedical Research (IDIBELL), Barcelona, Spain.
Institut d'Investigació Biomédica de Bellvitge · ESBrigham and Women's Hospital · USInstituto de Salud Carlos III · ESSt. Antonius Ziekenhuis · NLHospital Universitario de La Princesa · ESHospital Universitario Puerta de Hierro Majadahonda · ESInstitut d'Investigació en Ciències de la Salut Germans Trias i Pujol · ESUniversidad de Granada · ESVall d'Hebron Institut de Recerca · ESSeoul National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionLymphangioleiomyomatosis (LAM) is a rare low-grade metastasising disease characterised by cystic lung destruction. The genetic basis of LAM remains incompletely determined, and the disease cell-of-origin is uncertain. We analysed the possibility of a shared genetic basis between LAM and cancer, and LAM and pulmonary function.

methodsThe results of genome-wide association studies of LAM, 17 cancer types and spirometry measures (forced expiratory volume in 1 s (FEV

resultsThere were no significant overall genetic correlations between LAM and cancer, but LAM correlated negatively with FVC and PEF, and a trend in the same direction was observed for FEV

conclusionsThis study suggests the existence of a common genetic aetiology between LAM and pulmonary function.

Identifiers

PMID35083324
PMCPMC8784893
OpenAlexW3208547347

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.