ArticleERJ open research2022
Evaluation of spirometry-gated computed tomography to measure lung volumes in emphysema patients.
Article in ERJ open research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- Endobronchial Valve Treatment Improves Regional Specific Ventilation in the Target Lung.Respiration; international review of thoracic diseases · 2026Article
- Lung volume assessment for mean dark-field coefficient calculation using different determination methods.European radiology experimental · 2025Article
- Reference formulas for chest CT-derived lobar volumes in the lung-healthy general population.European radiology · 2025Article
- Lung volumes by computed tomography and plethysmography: are we measuring the same? CanCOLD study data.ERJ open research · 2025Article
- Article
- Size-matching in lung transplantation by computed tomography for end-stage interstitial disease: a retrospective analysis.Journal of thoracic disease · 2024Article
- Comparison of lung volumes measured with computed tomography and whole-body plethysmography - a systematic review.European clinical respiratory journal · 2024Review
- Artificial Intelligence Techniques to Predict the Airway Disorders Illness: A Systematic Review.Archives of computational methods in engineering : state of the art reviews · 2023Review
- Compatibility analysis of total lung capacity values measured by segmentation with computed tomography and helium dilution method.Annals of thoracic medicineArticle
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionIn emphysema patient being evaluated for bronchoscopic lung volume reduction (BLVR), accurate measurement of lung volumes is important. Total lung capacity (TLC) and residual volume (RV) are commonly measured by body plethysmography but can also be derived from chest computed tomography (CT). Spirometry-gated CT scanning potentially improves the agreement of CT and body plethysmography. The aim of this study was to compare lung volumes derived from spirometry-gated CT and "breath-hold-coached" CT to the reference standard: body plethysmography.
methodsIn this single-centre retrospective cohort study, emphysema patients being evaluated for BLVR underwent body plethysmography, inspiration (TLC) and expiration (RV) CT scan with spirometer guidance ("gated group") or with breath-hold-coaching ("non-gated group"). Quantitative analysis was used to calculate lung volumes from the CT.
results200 patients were included in the study (mean±sd age 62±8 years, forced expiratory flow in 1 s 29.2±8.7%, TLC 7.50±1.46 L, RV 4.54±1.07 L). The mean±sd CT-derived TLC was 280±340 mL lower compared to body plethysmography in the gated group (n=100), and 590±430 mL lower for the non-gated group (n=100) (both p<0.001). The mean±sd CT-derived RV was 300±470 mL higher in the gated group and 700±720 mL higher in the non-gated group (both p<0.001). Pearson correlation factors were 0.947 for TLC gated, 0.917 for TLC non-gated, 0.823 for RV gated, 0.693 for RV non-gated, 0.539 for %RV/TLC gated and 0.204 for %RV/TLC non-gated. The differences between the gated and non-gated CT results for TLC and RV were significant for all measurements (p<0.001).
conclusionIn severe COPD patients with emphysema, CT-derived lung volumes are strongly correlated to body plethysmography lung volumes, and especially for RV, more accurate when using spirometry gating.
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Registered trials
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