Evidence map›Paper›PMID 35083230›Full record

ArticleFrontiers in medicine2021

The Effects of Healthy Aging on Right Ventricular Structure and Biomechanical Properties: A Pilot Study.

Danial Sharifi Kia, Yuanjun Shen, Timothy N Bachman, Elena A Goncharova, Kang Kim, Marc A Simon

Open access · goldAbstract read
In one paragraph

Article in Frontiers in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Danial Sharifi KiaDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States.
Yuanjun ShenPittsburgh Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA, United States.
Timothy N BachmanDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States.
Elena A GoncharovaDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States.
Kang KimDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States.
Marc A SimonDivision of Cardiology, Department of Medicine, University of California, San Francisco, San Francisco, CA, United States.
University of Pittsburgh · USUniversity of Pittsburgh Medical Center · USUniversity of California, San Francisco · US

Funding

University of Pittsburgh Clinical and Translational Science InstituteUL1TR001857 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2016 to 2025
$129.3M
HIPPO Signaling in Pulmonary Arterial HypertensionR01HL130261 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GONCHAROVA, ELENA · 2016 to 2023
$3.5M
Phase II Trial of Metformin for Pulmonary Hypertension in Heart Failure with Preserved Ejection FractionR01AG058659 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SIMON, MARC A · 2018 to 2022
$3.2M
TSC2 Signaling in Pulmonary Arterial HypertensionR01HL113178 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GONCHAROVA, ELENA · 2012 to 2021
$3.1M
NCATS NIH HHS UL1 TR001857NHLBI NIH HHS R01 HL113178NHLBI NIH HHS R01 HL130261NIA NIH HHS R01 AG058659
6 · The paper itself

Abstract

Healthy aging has been associated with alterations in pulmonary vascular and right ventricular (RV) hemodynamics, potentially leading to RV remodeling. Despite the current evidence suggesting an association between aging and alterations in RV function and higher prevalence of pulmonary hypertension in the elderly, limited data exist on age-related differences in RV structure and biomechanics. In this work, we report our preliminary findings on the effects of healthy aging on RV structure, function, and biomechanical properties. Hemodynamic measurements, biaxial mechanical testing, constitutive modeling, and quantitative transmural histological analysis were employed to study two groups of male Sprague-Dawley rats: control (11 weeks) and aging (80 weeks). Aging was associated with increases in RV peak pressures (+17%,

Indexed as

aginghemodynamicsright ventricular biomechanicsright ventricular remodelingventricular structure

Identifiers

PMID35083230
PMCPMC8784691
OpenAlexW4206751626

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.