ArticleFrontiers in oncology2021
Impediment of Cerebrospinal Fluid Drainage Through Glymphatic System in Glioma.
Article in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 36 citations in OpenAlex.
- Glymphatic system dysfunction in central nervous system malignancies: A narrative review.Neurosurgical review · 2026Review
- Spatial organization of AQP4 water channel expression in the human brain.Science advances · 2026Article
- Leptomeningeal fibroblasts promote glioblastoma progression by regulating cerebrospinal fluid dynamics.Nature communications · 2026Article
- The glymphatic system and glioblastoma.Brain : a journal of neurology · 2026Review
- Diffusion tensor image analysis along the perivascular space may serve as a potential biomarker for differentiating glioma recurrence from pseudoprogression: a preliminary study.Quantitative imaging in medicine and surgery · 2026Article
- Altered perivascular diffusivity in glioblastoma: integrating DTI-ALPS index with radio-pathomic and histopathologic correlates.Journal of neuro-oncology · 2026Article
- The Extracellular Matrix, the Silent 'Architect' of Glioma.Biomedicines · 2026Review
- Contralateral neurofluid dynamics predict survival in IDH wild-type glioblastoma: A DTI-ALPS and free water imaging study.Neuro-oncology · 2026Article
- Ultrasonic modulation of brain glymphatic transport: from observations to theranostic applications.Cancer drug resistance (Alhambra, Calif.) · 2026Review
- Altered Perivascular Diffusivity in Glioblastoma:Integrating DTI-ALPS Index with Radio-Pathomicand Histopathologic Correlates.Research square · 2025Article
- The glymphatic system in oncology: from the perspective of a radiation oncologist.Journal of radiation research · 2025Review
- Noninvasive assessment of glymphatic dysfunction and IDH mutation in glioma with DTI-ALPS and DTI metrics.Quantitative imaging in medicine and surgery · 2025Article
- Glymphatic system dysfunction and cerebrospinal fluid retention in gliomas: evidence from perivascular space diffusion and volumetric analysis.Cancer imaging : the official publication of the International Cancer Imaging Society · 2025Article
- Aquaporin-4 in glioblastoma: a nexus of glymphatic dysfunction, edema, immune evasion, and treatment resistance.Frontiers in cellular neuroscience · 2025Review
- Assessing glymphatic dysfunction using the diffusion tensor image analysis along the perivascular space (DTI-ALPS) index in gliomas and metastases.Polish journal of radiology · 2025Article
- Functional and Clinical Relevance of the Crosstalk between the Glymphatic System and the Lymphatic System.Current neuropharmacology · 2025Review
- Simulating the impact of tumor mechanical forces on glymphatic networks in the brain parenchyma.Biomechanics and modeling in mechanobiology · 2024Article
- A Histopathologic Correlation Study Evaluating Glymphatic Function in Brain Tumors by Multiparametric MRI.Clinical cancer research : an official journal of the American Association for Cancer Research · 2024Article
- Glioma immune microenvironment composition calculator (GIMiCC): a method of estimating the proportions of eighteen cell types from DNA methylation microarray data.Acta neuropathologica communications · 2024Article
- Glymphatic function assessment with diffusion tensor imaging along the perivascular space in patients with major depressive disorder and its relation to cerebral white-matter alteration.Quantitative imaging in medicine and surgery · 2024Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCerebrospinal fluid (CSF) plays an important role in maintaining tissue homeostasis in the central nervous system. In 2012, the new CSF outflow pathway, "the glymphatic system," was discovered. The glymphatic system mediates CSF and interstitial fluid exchange through the perivascular pathway, which eliminates harmful solutes in the brain parenchyma. In recent studies, the importance of the glymphatic system has been demonstrated in healthy and neurodegenerative disease brains. However, there is limited research on the function of the CSF in brain tumors. Intracranial hypertension caused by glioma can affect CSF drainage, which impacts the delivery of chemotherapy drugs
methodsIn glioma-bearing rats, the effect of tracer infusion on the intracranial pressure (ICP) was evaluated using an ICP microsensor.
resultsThe ICP of the tumor group was higher than that of the control group and the infusion rate of 2 µl/min did not affect ICP.
conclusionsThese findings indicate that the para-arterial influx of subarachnoid CSF is limited in glioma, especially in those with reduced levels of the fundamental protein AQP4. Our results provide evidence toward a potential new treatment method for glioma in the future.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.