Evidence map›Paper›PMID 35083004›Full record

ArticleIranian journal of basic medical sciences2021

Protective effect of cannabinoids on gastric mucosal lesions induced by water immersion restrain stress in rats.

Rania Elgohary, Rania M Abdelsalam, Omar Me Abdel-Salam, Mahmoud M Khattab, Neveen A Salem, Zakaria A El-Khyat, Fatma A Morsy

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Iranian journal of basic medical sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Rania ElgoharyNarcotics, Ergogenics and Poisons Department, National Research Centre (NRC), Cairo, Egypt.
Rania M AbdelsalamPharmacology and Toxicology Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Omar Me Abdel-SalamNarcotics, Ergogenics and Poisons Department, National Research Centre (NRC), Cairo, Egypt.
Mahmoud M KhattabPharmacology and Toxicology Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Neveen A SalemNarcotics, Ergogenics and Poisons Department, National Research Centre (NRC), Cairo, Egypt.
Zakaria A El-KhyatMedical Biochemistry Department, National Research Centre (NRC), Cairo, Egypt.
Fatma A MorsyClinical Pathology Department, National Research Centre (NRC), Cairo, Egypt.
National Research Centre · EGCairo University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis study aimed to determine the impact of cannabinoid agonists and antagonists on the mucosal lesion progress in the stomach induced by water-immersion restraint stress (WIRS). MATERIALS AND

methodsRats subjected to WIRS for 4 hr were treated with Dimethyl sulfoxide (DMSO), CBR1 agonist (NADA, 1 mg/kg), CBR1 antagonist (Rimonabant, 1 mg/kg), CBR2 agonist (GW405833 1 mg/kg) or CBR2 antagonist (AM630, 1 mg/kg SC) 30 min before WIRS. Microscopic lesions, oxidative stress, inflammatory cytokines biomarkers, and (Myeloperoxidase) MPO in gastric tissues were determined.

resultsResults indicated development of severe gastric lesions with a substantial increase in the contents of (nitric oxide) NO, (malondialdehyde) MDA, (interleukin-1 beta) IL-1β, MPO, (tumor necrosis factor-alpha) TNF-α, and a significant fall in the content of GSH and the activity of PON-1 after WIRS.

conclusionTreatment with NADA and AM630 protected gastric tissues against ulcers as demonstrated by a decrease in the contents of MDA, TNF-α, MPO, and IL-1β along with an increase in the content of PON-1 activity and GSH in the stomach tissues. On the other hand, treatment with SR141716A or GW405833 showed no protective effects on ulcers development. It seems that cannabinoids exert their antioxidant potential and anti-inflammatory effects against WIRS-induced gastric ulcers by activation of CB1R.

Indexed as

Anti-oxidantCannabinoid receptorStressTNF-αUlcer

Identifiers

PMID35083004
PMCPMC8751742
OpenAlexW3192867632

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.