Evidence map›Paper›PMID 35082970›Full record

ArticleOxidative medicine and cellular longevity2022

Diet-Derived Circulating Antioxidants and Risk of Stroke: A Mendelian Randomization Study.

Rujia Miao, Jing Li, Changjiang Meng, Yalan Li, Haibo Tang, Jie Wang, Peizhi Deng, Yao Lu

Open access · hybridAbstract read
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In one paragraph

Article in Oxidative medicine and cellular longevity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 2 countries.

Rujia Miao *Health Management Center, The Third Xiangya Hospital, Central South University, Changsha, China.
Jing Li *Department of Rehabilitation, The Second Xiangya Hospital, Central South University, Changsha, China.
Changjiang MengDepartment of Cardiology, The Third Xiangya Hospital, Central South University, Changsha, China.
Yalan LiDepartment of Cardiology, The Third Xiangya Hospital, Central South University, Changsha, China.
Haibo TangDepartment of Metabolic and Bariatric Surgery, The Third Xiangya Hospital, Central South University, Changsha, China.
Jie WangDepartment of Cardiology, The Third Xiangya Hospital, Central South University, Changsha, China.ORCID https://orcid.org/0000-0003-3278-2708
Peizhi DengDepartment of Cardiology, The Third Xiangya Hospital, Central South University, Changsha, China.
Yao LuHealth Management Center, The Third Xiangya Hospital, Central South University, Changsha, China.ORCID https://orcid.org/0000-0001-6743-7870
Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOxidative stress is crucial in stroke pathogenesis. Many cohort-based studies suggested that the intake of exogenous antioxidants originated from food may prevent stroke. However, the corresponding randomized controlled trials did not show diet-derived antioxidants have a protective effect on stroke.

objectivesTo examine the association of genetically proxied diet-derived antioxidants with stroke risk using Mendelian randomization.

methodsWe performed a two-sample Mendelian randomization (MR) analysis to evaluate the causal effect of diet-derived antioxidants on stroke risk. For exposure data, we extracted genetic variants as instrumental variables (IVs) that are strongly associated with frequently used diet-derived antioxidants, including vitamin C, vitamin E (

resultsAccording to the primary MR estimations and further sensitivity analyses, we established two robust associations after Bonferroni correction: genetically proxied circulating

conclusionOur study revealed a protective impact of genetic susceptibility to high circulating

Indexed as

AntioxidantsDiet TherapyHumansMendelian Randomization AnalysisOxidative StressRisk FactorsStrokeAntioxidants

Identifiers

PMID35082970
PMCPMC8786473
OpenAlexW4205711390

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.