ArticleDisease markers2022
Red Cell Distribution Width to Platelet Ratio Is Associated with Increasing In-Hospital Mortality in Critically Ill Patients with Acute Kidney Injury.
Article in Disease markers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- The prognostic value of elevated neutrophil-lymphocyte ratio for cardiac surgery-associated acute kidney injury: A systematic review and meta-analysis.Acta anaesthesiologica Scandinavica · 2023Pooled it
- Prognostic value of RDW and its derivatives in ICU patients with hypertensive chronic kidney disease.BMC cardiovascular disorders · 2026Article
- Association between HALP score and in-hospital outcomes in patients with acute kidney injury: a retrospective cohort study.Scientific reports · 2026Article
- Higher red blood cell distribution width to platelet count ratio is associated with increased cardiovascular events in peritoneal dialysis patients.BMC nephrology · 2026Article
- Postoperative red cell distribution width to platelet ratio is related to cardiac surgery-associated acute kidney injury.BMC cardiovascular disorders · 2026Article
- Article
- Interpretable machine learning for the early prediction of acute kidney injury in preterm infants in the neonatal intensive care unit.Renal failure · 2025Article
- Association between the red cell distribution width-to-platelet ratio and 30-day all-cause mortality among patients with acute respiratory failure: a retrospective analysis of the MIMIC-IV database.BMC pulmonary medicine · 2025Article
- Hematologic Ratios in Donkeys: Reference Intervals and Response to Experimentally Induced Endotoxemia.Animals : an open access journal from MDPI · 2025Article
- The effect of inflammatory markers on mortality in patients with acute myocardial infarction.Scientific reports · 2025Article
- Machine learning algorithm for predict the in-hospital mortality in critically ill patients with congestive heart failure combined with chronic kidney disease.Renal failure · 2024Article
- Machine learning models for mortality prediction in critically ill patients with acute pancreatitis-associated acute kidney injury.Clinical kidney journal · 2024Article
- Diagnostic significance of complete blood cell count and hemogram-derived markers for neonatal sepsis at Southwest Public Hospitals, Ethiopia.World journal of clinical pediatrics · 2024Article
- A Systematic Review and Meta-Analysis of Mean Platelet Volume and Platelet Distribution Width in Patients with Obstructive Sleep Apnoea Syndrome.Biomedicines · 2024Review
- Predictive Value of Red Cell Distribution Width-to-Platelet Ratio Combined with Procalcitonin in 28-day Mortality for Patients with Sepsis.Critical care research and practice · 2024Article
- Association of red blood cell distribution width to albumin ratio with prognosis in stroke patients.Biomarkers in medicine · 2024Article
- Association between platelet-to-red cell distribution width ratio and all-cause mortality in critically ill patients with non-traumatic cerebral hemorrhage: a retrospective cohort study.Frontiers in neurology · 2024Article
- Machine learning algorithm to predict the in-hospital mortality in critically ill patients with chronic kidney disease.Renal failure · 2023Article
- Evaluation of Haematological Parameters and Uric Acid in the Diagnosis of Late Onset Neonatal Sepsis.Cureus · 2023Article
- Machine learning algorithm to predict mortality in critically ill patients with sepsis-associated acute kidney injury.Scientific reports · 2023Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInflammation plays a key role in the pathophysiology and progression of acute kidney injury (AKI). Red cell distribution width (RDW) to platelet ratio (RPR) is a novel inflammatory index, and its prognostic effect on critically ill patients with AKI is rarely investigated. This work is aimed at investigating the association between RPR and in-hospital mortality in these patients.
methodsData were extracted from the Medical Information Mart for Intensive Care III database. All-cause death during hospitalization was selected as the primary outcome. Receiver operating characteristic (ROC) curve was used to determine the optimal cut-off value, and the area under the curve (AUC) was applied to compare predictive ability among different indices. Cox proportional hazard models were utilized to assess the association between RPR and in-hospital mortality. Restricted cubic spline analysis for multivariate Cox model was performed to explore the shape of the relationship between RPR and mortality.
resultsA total of 24,166 critically ill patients with AKI were included. The relationship of RPR and in-hospital mortality was nonlinear with a trend to rise rapidly and then gradually. For mortality prediction, RPR had the optimal cut-off value of 0.093, of which the AUC was 0.791 (95% confidence interval (CI): 0.773-0.810), which was higher than those of RDW, platelet, sequential organ failure assessment score, simplified acute physiology score II, neutrophil to lymphocyte ratio, and platelet to lymphocytes ratio. After adjustments for various confounders, high RPR showed a significant association with increased mortality with hazard ratios of 1.46 (95% CI: 1.40-1.55) for categorical variable and 1.88 (95% CI: 1.80-1.97) for continuous variables in the fully adjusted model.
conclusionsElevated RPR on admission is substantially associated with high risk of in-hospital mortality in critically ill patients with AKI and thus may serve as a novel predictor of prognosis for these patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.