Evidence map›Paper›PMID 35082778›Full record

ArticleFrontiers in immunology2021

Fine Mapping Analysis of the MHC Region to Identify Variants Associated With Chinese Vitiligo and SLE and Association Across These Diseases.

Lu Cao, Ruixue Zhang, Yirui Wang, Xia Hu, Liang Yong, Bao Li, Huiyao Ge, Weiwei Chen, Qi Zhen, Yafen Yu and 4 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Lu CaoDepartment of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Ruixue ZhangDepartment of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Yirui WangDepartment of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Xia HuDepartment of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Liang YongDepartment of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Bao LiThe Comprehensive Lab, College of Basic Medicine, Anhui Medical University, Hefei, China.
Huiyao GeDepartment of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Weiwei ChenDepartment of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Qi ZhenDepartment of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Yafen YuDepartment of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Yiwen MaoDepartment of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Zhuo LiDepartment of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Wencheng FanDepartment of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Liangdan SunDepartment of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Anhui Medical University · CNFirst Affiliated Hospital of Anhui Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The important role of MHC in the pathogenesis of vitiligo and SLE has been confirmed in various populations. To map the most significant MHC variants associated with the risk of vitiligo and SLE, we conducted fine mapping analysis using 1117 vitiligo cases, 1046 SLE cases and 1693 healthy control subjects in the Han-MHC reference panel and 1000 Genomes Project phase 3. rs113465897 (P=1.03×10

Indexed as

AllelesAsian PeopleCase-Control StudiesFemaleGenetic Predisposition to DiseaseHistocompatibility AntigensHLA-DP beta-ChainsHLA-DQ beta-ChainsHumansLupus Erythematosus, SystemicMalePolymorphism, Single NucleotideVitiligoHistocompatibility AntigensHLA-DPB1 antigenHLA-DP beta-ChainsHLA-DQB1 antigenHLA-DQ beta-Chainsfine mappingimputationMHCsystemic lupus erythematosusvitiligo

Identifiers

PMID35082778
PMCPMC8784546
OpenAlexW4205660489

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.