ArticleFrontiers in physiology2021
Computational Modeling of Drug Dissolution in the Human Stomach.
Article in Frontiers in physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed, 18 citations in OpenAlex.
- Review
- Enhanced Endoscopic Internal Drainage of Gastric Abscess Through Additively Manufactured Stents.Advanced healthcare materials · 2026Article
- Overcoming the Challenges of Viscous Simulated Fed State Media with a Computerized Numerical Control Tablet Disintegration and Dissolution Tester.AAPS PharmSciTech · 2026Article
- Article
- Article
- Gastric emptying performance of stomach-partitioning gastrojejunostomyFrontiers in bioengineering and biotechnology · 2023Article
- Effect of stomach motility on food hydrolysis and gastric emptying: Insight from computational models.Physics of fluids (Woodbury, N.Y. : 1994) · 2022Article
- Computational modeling of drug dissolution in the human stomach: Effects of posture and gastroparesis on drug bioavailability.Physics of fluids (Woodbury, N.Y. : 1994) · 2022Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
A computational model of drug dissolution in the human stomach is developed to investigate the interaction between gastric flow and orally administrated drug in the form of a solid tablet. The stomach model is derived from the anatomical imaging data and the motion and dissolution of the drug in the stomach are modeled via fluid-structure interaction combined with mass transport simulations. The effects of gastric motility and the associated fluid dynamics on the dissolution characteristics are investigated. Two different pill densities are considered to study the effects of the gastric flow as well as the gravitational force on the motion of the pill. The average mass transfer coefficient and the spatial distributions of the dissolved drug concentration are analyzed in detail. The results show that the retropulsive jet and recirculating flow in the antrum generated by the antral contraction wave play an important role in the motion of the pill as well as the transport and mixing of the dissolved drug concentration. It is also found that the gastric flow can increase the dissolution mass flux, especially when there is substantial relative motion between the gastric flow and the pill.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.