Evidence map›Paper›PMID 35082671›Full record

ArticleFrontiers in pharmacology2021

Scorpion Venom Antimicrobial Peptides Induce Caspase-1 Dependant Pyroptotic Cell Death.

Ranwa A Elrayess, Mahmoud E Mohallal, Yomn M Mobarak, Hala M Ebaid, Sarah Haywood-Small, Keith Miller, Peter N Strong, Mohamed A Abdel-Rahman

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Article
  3. Characterization ofToxins · 2025
    Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. New prospects of cancer therapy based on pyroptosis and pyroptosis inducers.Apoptosis : an international journal on programmed cell death · 2024
    Review
  9. Review
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Ranwa A ElrayessBiomolecular Sciences Research Centre, Sheffield Hallam University, Sheffield, United Kingdom.
Mahmoud E MohallalZoology Department, Faculty of Science, Suez Canal University, Ismailia, Egypt.
Yomn M MobarakZoology Department, Faculty of Science, Suez University, Suez, Egypt.
Hala M EbaidZoology Department, Faculty of Science, Suez Canal University, Ismailia, Egypt.
Sarah Haywood-SmallBiomolecular Sciences Research Centre, Sheffield Hallam University, Sheffield, United Kingdom.
Keith MillerBiomolecular Sciences Research Centre, Sheffield Hallam University, Sheffield, United Kingdom.
Peter N StrongBiomolecular Sciences Research Centre, Sheffield Hallam University, Sheffield, United Kingdom.
Mohamed A Abdel-RahmanZoology Department, Faculty of Science, Suez Canal University, Ismailia, Egypt.
Suez Canal University · EGSheffield Hallam University · GBSuez University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Within the last decade, several peptides have been identified according to their ability to inhibit the growth of microbial pathogens. These antimicrobial peptides (AMPs) are a part of the innate immune system of all living organisms. Many studies on their effects on prokaryotic microorganisms have been reported; some of these peptides have cytotoxic properties although the molecular mechanisms underlying their activity on eukaryotic cells remain poorly understood. Smp24 and Smp43 are novel cationic AMPs which were identified from the venom of the Egyptian scorpion

Indexed as

Antimicrobial peptidescaspase-1cell deathIL-1bpyroptosisscorpio maurus palmatusSmp24Smp43

Identifiers

PMID35082671
PMCPMC8784870
OpenAlexW4206322226

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.