ReviewFrontiers in systems neuroscience2021
Excitatory-Inhibitory Homeostasis and Diaschisis: Tying the Local and Global Scales in the Post-stroke Cortex.
Review in Frontiers in systems neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 31 citations in OpenAlex.
- Preventing slowing down of alpha rhythms in stroke patients through modulation of cortical excitatory-inhibitory balance: a randomized controlled trial.Journal of neuroengineering and rehabilitation · 2026Trial
- Neurorehabilitation in the 21st Century: New Science, New Strategies, New Expectations.Neurorehabilitation and neural repair · 2026Review
- Slow Oscillations Track Acute Stroke Injury but Not Functional Recovery.bioRxiv : the preprint server for biology · 2026Article
- Functional reorganization of the contralesional precentral gyrus following acute subcortical ischemic stroke and its association with gene expression profile.Journal of neuroengineering and rehabilitation · 2026Article
- Somatosensory cortex neuronal integrity is altered after stroke.Frontiers in human neuroscience · 2026Article
- Mechanistic explanation of neuroplasticity using equivalent circuits.Frontiers in computational neuroscience · 2026Article
- Clinical development and guiding theory of transcranial magnetic stimulation: a literature review.Annals of medicine · 2025Review
- Parvalbumin interneurons regulate rehabilitation-induced functional recovery after stroke and identify a rehabilitation drug.Nature communications · 2025Article
- Metastable dynamics emerge from local excitatory-inhibitory homeostasis in the cortex at rest.Network neuroscience (Cambridge, Mass.) · 2025Article
- Role of homeostatic plasticity in critical brain dynamics following focal stroke lesions.Scientific reports · 2024Article
- Two-photon optogenetics-based assessment of neuronal connectivity in healthy and chronic hypoperfusion mice.Neurophotonics · 2024Article
- Disentangling neuroplasticity mechanisms in post-stroke language recovery.Brain and language · 2024Review
- Deep brain stimulation combined with morroniside promotes neural plasticity and motor functional recovery after ischemic stroke.Frontiers in pharmacology · 2024Article
- Multi-modal and multi-model interrogation of large-scale functional brain networks.NeuroImage · 2023Article
- Multiscale effects of excitatory-inhibitory homeostasis in lesioned cortical networks: A computational study.PLoS computational biology · 2023Article
- Cortical connectivity in stroke using signals from resting-state EEG: a review of current literature.Acta neurologica Belgica · 2023Review
- Patient-specific modeling for guided rehabilitation of stroke patients: the BrainX3 use-case.Frontiers in neurology · 2023Article
- Structural-and-dynamical similarity predicts compensatory brain areas driving the post-lesion functional recovery mechanism.Cerebral cortex communications · 2023Article
- From mechanisms to markers: novel noninvasive EEG proxy markers of the neural excitation and inhibition system in humans.Translational psychiatry · 2022Review
- Whole-Brain Network Models: From Physics to Bedside.Frontiers in computational neuroscience · 2022Review
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Maintaining a balance between excitatory and inhibitory activity is an essential feature of neural networks of the neocortex. In the face of perturbations in the levels of excitation to cortical neurons, synapses adjust to maintain excitatory-inhibitory (EI) balance. In this review, we summarize research on this EI homeostasis in the neocortex, using stroke as our case study, and in particular the loss of excitation to distant cortical regions after focal lesions. Widespread changes following a localized lesion, a phenomenon known as diaschisis, are not only related to excitability, but also observed with respect to functional connectivity. Here, we highlight the main findings regarding the evolution of excitability and functional cortical networks during the process of post-stroke recovery, and how both are related to functional recovery. We show that cortical reorganization at a global scale can be explained from the perspective of EI homeostasis. Indeed, recovery of functional networks is paralleled by increases in excitability across the cortex. These adaptive changes likely result from plasticity mechanisms such as synaptic scaling and are linked to EI homeostasis, providing a possible target for future therapeutic strategies in the process of rehabilitation. In addition, we address the difficulty of simultaneously studying these multiscale processes by presenting recent advances in large-scale modeling of the human cortex in the contexts of stroke and EI homeostasis, suggesting computational modeling as a powerful tool to tie the meso- and macro-scale processes of recovery in stroke patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.