Evidence map›Paper›PMID 35082516›Full record

ArticleInternational journal of general medicine2022

Immunogenetic Relationship of

Shrouk A Mohammed, Laila M Al Kady, Ghada S Boghdadi, Ghada A Dawa, Marian A Gerges, Maher A El Shafai

Open access · goldAbstract read
In one paragraph

Article in International journal of general medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Shrouk A MohammedMedical Microbiology and Immunology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.ORCID 0000-0003-3522-9991
Laila M Al KadyMedical Microbiology and Immunology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Ghada S BoghdadiMedical Microbiology and Immunology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.ORCID 0000-0003-1152-1197
Ghada A DawaRheumatology and Rehabilitation Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Marian A GergesMedical Microbiology and Immunology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.ORCID 0000-0002-9631-0585
Maher A El ShafaiMedical Microbiology and Immunology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Zagazig University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe level of expression of the immunoregulatory human leukocyte antigen-G (HLA-G) has been suggested to play a role in the immunopathogenesis of systemic lupus erythematosus (SLE). A 14 bp insertion/deletion (ins/del) polymorphism in the 3'untranslated region of PURPOSE: To detect the association of PATIENTS AND

methodsA case-control study that included 102 SLE female patients and 102 healthy matched volunteers as controls was carried out. Disease activity in patients was determined using the modified Systemic Lupus Erythematosus Disease Activity Index (SLEDAI).

resultsThe ins/ins genotype was significantly increased among SLE patients compared to healthy subjects (58.8% vs 9.8%; odds ratio [OR] = 11.79, P < 0.001). The 14 bp ins allele was significantly more frequent in SLE patients than in healthy subjects (65.7% vs 27.9%, respectively) and significantly associated with an increased risk of SLE (OR 4.94, P < 0.001). The mean TLR9 serum level showed a significant increase in SLE patients compared to healthy subjects (397.04±137.86 vs 195.22±45.14 ng/L, p < 0.001) and was significantly associated with disease activity as well as to patients'

conclusionAmong Egyptian population,

Indexed as

gene polymorphismhuman leukocyte antigen-Gsystemic lupus erythematosusToll-like receptor 9

Identifiers

PMID35082516
PMCPMC8785136
OpenAlexW4206015187

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.