ArticleJournal of inflammation research2022
Establishment and Effectiveness Evaluation of a Scoring System-RAAS (RDW, AGE, APACHE II, SOFA) for Sepsis by a Retrospective Analysis.
Article in Journal of inflammation research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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16 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Diagnostic value of RDW for the prediction of mortality in adult sepsis patients: A systematic review and meta-analysis.Frontiers in immunology · 2022Pooled it
- Association between hemoglobin-to-red blood cell distribution width ratio and 28-day all-cause mortality in patients with acute kidney injury: A cross-sectional study.The Journal of international medical research · 2026Article
- Relationship between red cell distribution width to albumin ratio (RAR) and mortality in ICU patients with sepsis-associated ARDS: a retrospective study based on MIMIC-IV.BMC infectious diseases · 2026Article
- Establishment and validation of the prediction model based on lymphocyte subsets for acute kidney injury in sepsis patients.Frontiers in immunology · 2025Article
- Prophylactic proton pump inhibitor use and all-cause mortality in adult sepsis patients: a retrospective analysis based on the MIMIC-IV database.Frontiers in pharmacology · 2025Article
- A Simplified Immune-Dysregulation Index (IL-6/LY) as a Robust Predictor of 28-Day In-Hospital Mortality and MODS in Patients with Sepsis.Journal of inflammation research · 2025Article
- Article
- Assessment of Sepsis Risk at Admission to the Emergency Department: Clinical Interpretable Prediction Model.Diagnostics (Basel, Switzerland) · 2024Article
- Association Between Plasma Levels of Monocyte Chemoattractant Protein-1 (MCP-1) and 28-Day Mortality in Elderly Patients with Sepsis: A Retrospective Single-Center Study.Medical science monitor : international medical journal of experimental and clinical research · 2024Article
- Diagnostic Value of RDW-Albumin Ratio for the Prediction of Mortality in Sepsis Associated Nonthyroidal Illness Syndrome Patients: A Retrospective Cohort Study.Journal of inflammation research · 2024Article
- Study on the Predictive Value of Renal Resistive Index Combined with β2-Microglobulin in Patients with Urosepsis Complicated with Acute Kidney Injury.Journal of inflammation research · 2024Article
- Interpretable machine learning-based prediction of 28-day mortality in ICU patients with sepsis: a multicenter retrospective study.Frontiers in cellular and infection microbiology · 2024Article
- A simplified machine learning model utilizing platelet-related genes for predicting poor prognosis in sepsis.Frontiers in immunology · 2023Article
- Comparing the clinical and economic efficiency of four natural surfactants in treating infants with respiratory distress syndrome.PloS one · 2023Article
- Article
- Sepsis Heterogeneity and Progression: Appraisal of Scoring System [Letter].Journal of inflammation research · 2022Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA modified scoring system based on the RDW, AGE, SOFA, and APACHE II score (RAAS score) was composed to investigated the short-, medium-, and long-term high risk of mortality in patients with sepsis identified early in the emergency department (ED).
methodsData were collected from a total of 1066 sepsis patients in emergency department, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine from March 2013 to April 2021, including 529 patients in the primary cohort and 537 patients in the validation cohort. By comparing each parameter and the area under ROC (AUC) and K-M (Kaplan-Meier) survival curve in different periods, valuable parameters were screened out to form a new scoring system, and finally the prediction model of the nomogram was built.
resultsThe RAAS scoring system, consisting of RDW, AGE, SOFA and APACHE II, is a 0-6 scale to reflect the severity of sepsis. AUC at 30, 60, and 90 days was 0.816, 0.815, and 0.820, respectively. K-M curves across six prognostic time periods in both databases showed survival probabilities with different RDW segments and RAAS scores. In the calibration curve, the results of the internal validation of the primary cohort and the results of the external validation cohort showed the prognostic accuracy of RAAS.
conclusionThe RAAS score system is a novel and reliable indicator to predict the short-term and medium-term mortality of patients with sepsis. With the increase of the RAAS score, the mortality of patients with sepsis gradually increases.
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