ArticleInternational journal of chronic obstructive pulmonary disease
Long-Term Effect of Noninvasive Ventilation on Diaphragm in Chronic Respiratory Failure.
Article in International journal of chronic obstructive pulmonary disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 6 citations in OpenAlex.
- Clinical analysis of 45 cases of chronic respiratory failure treated by noninvasive ventilator combined with bronchodilator and anti-infective drugs.European journal of medical research · 2025Trial
- Rehabilitating the diaphragm: an integrated approach to intensive care unit-acquired dysfunction in critical illness-a narrative review.Acute and critical care · 2026Article
- Diaphragmatic Thickening Fraction and Excursion: Different Clinical Values in Non-Critically Ill Patients with AECOPD - An Exploratory Study.International journal of chronic obstructive pulmonary disease · 2026Observational
- Beyond blood gases: diaphragm-guided sequential non-invasive ventilation for COPD with type II respiratory failure.Frontiers in medicine · 2026Review
- Diaphragm and Lung Transplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2024Review
- Acute COPD exacerbation treatment with noninvasive ventilation.Scientific reports · 2023Article
- Chronic hypercapnic respiratory failure and non-invasive ventilation in people with chronic obstructive pulmonary disease.BMJ medicine · 2022Review
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeHome non-invasive ventilation (NIV) is recommended in patients with COPD and hypercapnic chronic respiratory failure (HCRF). The mechanism by it can improve alveolar ventilation during spontaneous breathing is not yet completely explained. Our aim is to evaluate the impact of on diaphragm muscle function in a series of patients with HCRF. PATIENTS AND
methodsObservational, longitudinal, prospective study of a series of patients with very severe chronic obstruction to airflow treated with home high imntensity NIV (HINIV). Patients underwent a baseline and after 12 months assessment including adherence to treatment, quality of life, respiratory function tests and diaphragmatic ultrasound. SPSS v.26 software was used for statistical analysis.
resultsWe studied 30 patients, 63% male, the mean age was 60.8 (±6.4) years old. Patients had a severe obstructive ventilatory pattern [FEV1 21.8 (±6.1)%] and hypercapnia [pCO2 56.4 (±7.2) mmHg]. After 12 months of HINIV, we observed significant increases in FVC of 9.2% (p = 0.002), FEV1 of 3.5% (p = 0.04), MIP of 9.4% (p = 0.006), and 6-minute-walking test (6MWT) of 31.9 m (p = 0.001), as well as decreases in paCO2 of 12.5 mmHg (p = 0.001), HCO3 of 4.7 mmol/L (p = 0.001) and BODE index from 7 to 6. Diaphragmatic ultrasound demonstrated an increase in the thickening fraction of 14% (p = 0.002). Respiratory symptoms (p = 0.04), physical function (p = 0.03), and sleep (p = 0.04) also improved.
conclusionIn patients with HCRF due to very severe chronic obstruction to airflow, long-term HINIV can improve respiratory performance by improving the function of the diaphragmatic musculature. Larger multicenter clinical trials are needed to confirm the results suggested in this study.
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