Evidence map›Paper›PMID 35082448›Full record

ArticleNature2022

Sensory representation and detection mechanisms of gut osmolality change.

Takako Ichiki, Tongtong Wang, Ann Kennedy, Allan-Hermann Pool, Haruka Ebisu, David J Anderson, Yuki Oka

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 64 citations in OpenAlex.

  1. Article
  2. Vagal sensory neurons profusely innervate the mouse gall bladder.Autonomic neuroscience : basic & clinical · 2026
    Article
  3. The critical role of gut-brain signalling in eating behaviour and obesity.Nature reviews. Gastroenterology & hepatology · 2026
    Review
  4. Article
  5. Review
  6. Article
  7. The gut-brain axis: mechanisms linking intestinal dysbiosis with stroke.Frontiers in cell and developmental biology · 2026
    Review
  8. Molecular, anatomical, and functional organization of lung interoceptors.bioRxiv : the preprint server for biology · 2025
    Article
  9. Review
  10. Review
  11. Review
  12. Body fluid regulation.Current opinion in neurobiology · 2025
    Review
  13. Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Takako IchikiDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Tongtong WangDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.ORCID http://orcid.org/0000-0002-0408-2571
Ann KennedyDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Allan-Hermann PoolDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Haruka EbisuDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
David J AndersonDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.ORCID http://orcid.org/0000-0001-6175-3872
Yuki OkaDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA. yoka@caltech.edu.ORCID http://orcid.org/0000-0003-2686-0677
California Institute of Technology · USNorthwestern University · US

Funding

Multimodal, integrated analysis of neural activity and naturalistic social behavior in freely moving miceR01MH123612 · NIMH · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI ANDERSON, DAVID J, PERONA, PIETRO · 2020 to 2024
$2.1M
Dissecting sodium appetite circuits in the mammalian brainR01NS123918 · NINDS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI OKA, YUKI · 2021 to 2025
$2.0M
Neural circuits underlying thirst and satiety regulationR01NS109997 · NINDS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI OKA, YUKI · 2018 to 2022
$1.9M
Genetic dissection of the neural circuits regulating appetiteR56MH113030 · NIMH · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI OKA, YUKI · 2017 to 2018
$825k
NIMH NIH HHS R56 MH113030NINDS NIH HHS R01 NS109997NINDS NIH HHS R01 NS123918
6 · The paper itself

Abstract

Ingested food and water stimulate sensory systems in the oropharyngeal and gastrointestinal areas before absorption

Indexed as

IntestinesSatiationSensory Receptor CellsThirstGanglia, SensoryOsmolar ConcentrationOsmotic PressureVagus NerveWaterWater

Identifiers

PMID35082448
OpenAlexW4210565088

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.