ArticleNature2022
Brahma safeguards canalization of cardiac mesoderm differentiation.
Erratum issuedOpen access · greenAbstract read
In one paragraph
Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 29 papers.
0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
4.3field-weighted citation impact, top 4% of its field
What it found
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Who cites it
29 citing papers in PubMed, 57 citations in OpenAlex.
- A SWI/SNF-specific Ig-like domain, SWIFT, is a transcription factor binding platform.Science (New York, N.Y.) · 2026Article
- TGFβ-activated PDHB promotes mitochondrial pyruvate metabolism and contributes to human endoderm differentiation via ATP-dependent BRG1.Nature communications · 2026Article
- Global Evaluation of Congenital Heart Disease-Associated Non-Coding Variants.Research square · 2026Article
- Altered Cohesin Dynamics During Cellular Differentiation.bioRxiv : the preprint server for biology · 2026Article
- Elucidating Gene Functions in Congenital Heart Disease.Current treatment options in cardiovascular medicine · 2026Review
- BRG1 exacerbates myocardial fibrosis after myocardial infarction by interacting with ZEB1.Frontiers in pharmacology · 2026Article
- Activity of the SWI/SNF complex is indispensable for syncytiotrophoblast formation.Development (Cambridge, England) · 2025Article
- Epigenetic control of cell identities from epiblast to gastrulation.The FEBS journal · 2025Review
- Perinatal Exposure to Lead or Diethylhexyl Phthalate in Mice: Sex-Specific Effects on Cardiac DNA Methylation and Gene Expression across Time.Environmental health perspectives · 2025Article
- Logic-based modeling of biological networks with Netflux.PLoS computational biology · 2025Article
- Article
- GATA6 regulates WNT and BMP programs to pattern precardiac mesoderm during the earliest stages of human cardiogenesis.bioRxiv : the preprint server for biology · 2025Article
- Optical genome mapping uncovers clinically relevant structural variants in congenital heart disease with heterotaxy.Frontiers in genetics · 2025Article
- The SWI/SNF ATP-dependent chromatin remodeling complex in cell lineage priming and early development.Biochemical Society transactions · 2024Review
- A logic-incorporated gene regulatory network deciphers principles in cell fate decisions.eLife · 2024Article
- The SWI/SNF nucleosome remodeler constrains enhancer activity during Drosophila wing development.Genetics · 2024Article
- Endothelial cells adopt a pro-reparative immune responsive signature during cardiac injury.Life science alliance · 2024Article
- Multiple Cell Lineages Give Rise to a Cell Type.Results and problems in cell differentiation · 2024Article
- Zebrafish smarcc1a mutants reveal requirements for BAF chromatin remodeling complexes in distinguishing the atrioventricular canal from the cardiac chambers.Developmental dynamics : an official publication of the American Association of Anatomists · 2024Article
- The BAF chromatin remodeling complex licenses planarian stem cells access to ectodermal and mesodermal cell fates.BMC biology · 2023Article
Corrections and comments
- Erratum issued
Authors and funding
22 authors at 3 institutions in 1 country.
Swetansu K HotaGladstone Institutes, San Francisco, CA, USA. swetansu.hota@gladstone.ucsf.edu.ORCID http://orcid.org/0000-0003-3105-9729
Kavitha S RaoGladstone Institutes, San Francisco, CA, USA.
Andrew P BlairGladstone Institutes, San Francisco, CA, USA.
Ali KhalilimeybodiDepartment of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA.ORCID http://orcid.org/0000-0001-9318-8433
Kevin M HuGladstone Institutes, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-5513-7854
Reuben ThomasGladstone Institutes, San Francisco, CA, USA.
Kevin SoGladstone Institutes, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-5193-7384
Vasumathi KameswaranGladstone Institutes, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-2552-6183
Jiewei XuGladstone Institutes, San Francisco, CA, USA.
Benjamin J PolaccoGladstone Institutes, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-1570-9234
Ravi V DesaiGladstone Institutes, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-0336-0883
Nilanjana ChatterjeeDepartment of Medicine, University of California, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-1203-5222
Austin HsuGladstone Institutes, San Francisco, CA, USA.
Jonathon M MuncieGladstone Institutes, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-7405-6213
Aaron M BlotnickGladstone Institutes, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-8646-6853
Sarah A B WinchesterGladstone Institutes, San Francisco, CA, USA.
Leor S WeinbergerGladstone Institutes, San Francisco, CA, USA.
Ruth HüttenhainGladstone Institutes, San Francisco, CA, USA.
Irfan S KathiriyaGladstone Institutes, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-1207-1490
Nevan J KroganGladstone Institutes, San Francisco, CA, USA.
Jeffrey J SaucermanDepartment of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA.
Benoit G BruneauGladstone Institutes, San Francisco, CA, USA. benoit.bruneau@gladstone.ucsf.edu.ORCID http://orcid.org/0000-0002-0804-7597
Gladstone Institutes · USUniversity of Virginia · USUniversity of California, San Francisco · US
Funding
Administrative Coordinating Center: Cardiovascular Development and Pediatric Cardiac Genomics ConsortiaU01HL131003 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI CNOTA, JAMES, OLLBERDING, NICHOLAS J · 2016 to 2024
$54.8MTranscriptional Networks During Cardiac DifferentiationP01HL089707 · NHLBI · J. DAVID GLADSTONE INSTITUTES · PI SRIVASTAVA, DEEPAK · 2008 to 2017
$20.4MProject 3: Control of cardiac transcription by MEF2 and myocardinP01HL146366 · NHLBI · J. DAVID GLADSTONE INSTITUTES · PI SRIVASTAVA, DEEPAK · 2019 to 2023
$13.7MMOLECULAR AND CELLULAR BASIS OF CARDIOVASCULAR DISEASET32HL007731 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Brian L Black · 1992 to 2026
$12.4MThe Epigenetic Landscape of Heart DevelopmentU01HL098179 · NHLBI · J. DAVID GLADSTONE INSTITUTES · PI BOYER, LAURIE A, BRUNEAU, BENOIT GAETAN · 2009 to 2014
$10.0MEarly Cardiac ProgenitorsR01HL114948 · NHLBI · J. DAVID GLADSTONE INSTITUTES · PI Benoit Gaetan Bruneau · 2013 to 2026
$7.5MThe Epigenetic Landscape of Heart DevelopmentUM1HL098179 · NHLBI · J. DAVID GLADSTONE INSTITUTES · PI BRUNEAU, BENOIT GAETAN, POLLARD, KATHERINE S. · 2015 to 2019
$4.7MSystems Pharmacology Model of Cardiac HypertrophyR01HL162925 · NHLBI · UNIVERSITY OF VIRGINIA · PI SAUCERMAN, JEFFREY J., WOLF, MATTHEW J · 2022 to 2025
$3.1MComputational and Experimental Modeling of Cardiomyocyte ProliferationR01HL160665 · NHLBI · UNIVERSITY OF VIRGINIA · PI SAUCERMAN, JEFFREY J., VAN BERLO, JOHANNES (JOP) · 2022 to 2025
$2.8MEXTRAMULAR RESEARCH FACILITIES CONSTRUCTIONC06RR018928 · NCRR · J. DAVID GLADSTONE INSTITUTES · PI MAHLEY, ROBERT W. · 2003 to 2003
$2.1MSystems Pharmacology Model for Spatial Control of Cardiac FibrosisR01HL137755 · NHLBI · UNIVERSITY OF VIRGINIA · PI HOLMES, JEFFREY W, SAUCERMAN, JEFFREY J. · 2017 to 2020
$1.9MPediatric Heart Network Joint Heart Program ConsortiumUM1HL172717 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI Louis Bezold, James Cnota · 2024 to 2026
$1.3MAmerican Heart Association-American Stroke Association 13POST17290043American Heart Association-American Stroke Association 861914NCRR NIH HHS C06 RR018928NHLBI NIH HHS P01 HL089707NHLBI NIH HHS P01 HL146366NHLBI NIH HHS R01 HL114948NHLBI NIH HHS R01 HL137755NHLBI NIH HHS R01 HL160665NHLBI NIH HHS R01 HL162925NHLBI NIH HHS T32 HL007731NHLBI NIH HHS U01 HL098179NHLBI NIH HHS U01 HL131003NHLBI NIH HHS UM1 HL098179NHLBI NIH HHS UM1 HL172717
Abstract
Differentiation proceeds along a continuum of increasingly fate-restricted intermediates, referred to as canalization
Indexed as
Cell DifferentiationCell LineageAnimalsBone Morphogenetic Protein 4ChromatinChromatin Assembly and DisassemblyDNA HelicasesEmbryo, MammalianEpigenesis, GeneticFemaleGene Expression RegulationMaleMesodermMiceMyocardiumMyocytes, CardiacBmp4 protein, mouseBone Morphogenetic Protein 4ChromatinDNA HelicasesNuclear ProteinsOctamer Transcription Factor-6Pou3f1 protein, mouseRE1-Silencing Transcription FactorRepressor ProteinsSmarca2 protein, mouseSmarca4 protein, mouseTranscription Factors
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.