Evidence map›Paper›PMID 35082445›Full record

ArticleNature2022

Petabase-scale sequence alignment catalyses viral discovery.

Robert C Edgar, Brie Taylor, Victor Lin, Tomer Altman, Pierre Barbera, Dmitry Meleshko, Dan Lohr, Gherman Novakovsky, Benjamin Buchfink, Basem Al-Shayeb and 5 more

Open access · hybridAbstract read
PubMed Publisher
In one paragraph

Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 291 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
291citing papers in PubMed, 1 pooled it
80.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

291 citing papers in PubMed, 1 synthesis or guideline pooled it, 510 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. AnvRV virus in the parasitoid waspMicrobiology spectrum · 2026
    Article
  12. Article
  13. Review
  14. Article
  15. Article
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  18. Article
  19. Article
  20. Mycoviruses confer hypovirulence but enhance antifungal volatile organic compound production in a phytopathogenic fungus.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article

231 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 11 institutions in 7 countries.

Robert C Edgar *Independent researcher, Corte Madera, CA, USA.ORCID http://orcid.org/0000-0001-7355-2541
Brie Taylor *Independent researcher, Vancouver, British Columbia, Canada.
Victor Lin *Independent researcher, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-8670-3377
Tomer Altman *Altman Analytics, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-6521-5454
Pierre Barbera *Computational Molecular Evolution Group, Heidelberg Institute for Theoretical Studies, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-3437-150X
Dmitry Meleshko *Center for Algorithmic Biotechnology, St Petersburg State University, St Petersburg, Russia.
Dan Lohr *Unaffiliated, Atlanta, GA, USA.
Gherman Novakovsky *Bioinformatics Graduate Program, University of British Columbia, Vancouver, British Columbia, Canada.
Benjamin Buchfink *Computational Biology Group, Max Planck Institute for Biology, Tübingen, Germany.
Basem Al-Shayeb *Department of Plant and Microbial Biology, University of California, Berkeley, Berkeley, CA, USA.
Jillian F Banfield *Department of Earth and Planetary Science, University of California, Berkeley, Berkeley, CA, USA.ORCID http://orcid.org/0000-0001-8203-8771
Marcos de la Peña *Instituto de Biología Molecular y Celular de Plantas, Universidad Politécnica de Valencia-CSIC, Valencia, Spain.ORCID http://orcid.org/0000-0002-7949-8459
Anton Korobeynikov *Center for Algorithmic Biotechnology, St Petersburg State University, St Petersburg, Russia.
Rayan Chikhi *G5 Sequence Bioinformatics, Department of Computational Biology, Institut Pasteur, Paris, France.
Artem Babaian *Independent researcher, Vancouver, British Columbia, Canada. ab2788@cam.ac.uk.ORCID http://orcid.org/0000-0002-4315-6262
St Petersburg University · RUAID Atlanta · USHeidelberg Institute for Theoretical Studies · DEInstituto de Biología Molecular y Celular de Plantas · ESInstitut Pasteur · FRMax Planck Institute for Biology · DEOldham Council · GBPlanetary Science Institute · USUniversity of British Columbia · CAUniversity of California, Berkeley · USVerisk Analytics (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Public databases contain a planetary collection of nucleic acid sequences, but their systematic exploration has been inhibited by a lack of efficient methods for searching this corpus, which (at the time of writing) exceeds 20 petabases and is growing exponentially

Indexed as

Cloud ComputingDatabases, GeneticAnimalsArchivesBacteriophagesBiodiversityCoronavirusEvolution, MolecularHepatitis Delta VirusHumansModels, MolecularRNA-Dependent RNA PolymeraseRNA VirusesSequence AlignmentSoftwareVirologyRNA-Dependent RNA Polymerase

Identifiers

PMID35082445
OpenAlexW4221049439

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.