ArticleNature communications2022
Amino acid gas phase circular dichroism and implications for the origin of biomolecular asymmetry.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 34 citations in OpenAlex.
- Shaping light in 3D for direct asymmetric photochemistry: a 1000-fold enantioselectivity enhancement.Nature communications · 2026Article
- Spectroscopy and Conformer-Selective Photoelectron Circular Dichroism of Chiral Molecules.Chemistry, an Asian journal · 2026Review
- AScience advances · 2025Article
- Characterization of Amino Acid Nanolayers and Their Interactions under Simulated Planetary Conditions.ACS earth & space chemistry · 2025Article
- Chiral Amino Acids Mediate Mitochondria-Dependent Apoptosis of Human Proximal Tubular Epithelial Cells Under Oxidative Stress.International journal of molecular sciences · 2024Article
- Uncovering the chiral bias of meteoritic isovaline through asymmetric photochemistry.Nature communications · 2023Article
- Enantiomeric Excesses of Aminonitrile Precursors Determine the Homochirality of Amino Acids.The journal of physical chemistry letters · 2023Article
- Benchmark Structures and Conformational Landscapes of Amino Acids in the Gas Phase: A Joint Venture of Machine Learning, Quantum Chemistry, and Rotational Spectroscopy.Journal of chemical theory and computation · 2023Article
- Chiroptical activity of gas-phase propylene oxide predicting the handedness of interstellar circular polarization in the presolar nebula.Science advances · 2022Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Life on Earth employs chiral amino acids in stereochemical L-form, but the cause of molecular symmetry breaking remains unknown. Chiroptical properties of amino acids - expressed in circular dichroism (CD) - have been previously investigated in solid and solution phase. However, both environments distort the intrinsic charge distribution associated with CD transitions. Here we report on CD and anisotropy spectra of amino acids recorded in the gas phase, where any asymmetry is solely determined by the genuine electromagnetic transition moments. Using a pressure- and temperature-controlled gas cell coupled to a synchrotron radiation CD spectropolarimeter, we found CD active transitions and anisotropies in the 130-280 nm range, which are rationalized by ab initio calculation. As gas phase glycine was found in a cometary coma, our data may provide insights into gas phase asymmetric photochemical reactions in the life cycle of interstellar gas and dust, at the origin of the enantiomeric selection of life's L-amino acids.
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