Evidence map›Paper›PMID 35082285›Full record

ArticleNature communications2022

Mapping brain structural differences and neuroreceptor correlates in Parkinson's disease visual hallucinations.

Miriam Vignando, Dominic Ffytche, Simon J G Lewis, Phil Hyu Lee, Seok Jong Chung, Rimona S Weil, Michele T Hu, Clare E Mackay, Ludovica Griffanti, Delphine Pins and 8 more

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Article
  3. Gray Matter Volume Loss in Parkinson's Disease Psychosis and Cannabinoid Receptor Gene Expression in the Brain.Movement disorders : official journal of the Movement Disorder Society · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Combined Dysfunction of the Amygdala and Nucleus Basalis Underlies Visual Hallucinations in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2025
    Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. Article
  18. Genomic loci influence patterns of structural covariance in the human brain.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 8 institutions in 5 countries.

Miriam VignandoDepartment of Neuroimaging, King's College London, Institute of Psychiatry, Psychology and Neuroscience, De Crespigny Park, London, SE5 8AF, UK. miriam.vignando@kcl.ac.uk.ORCID http://orcid.org/0000-0002-7542-3089
Dominic FfytcheDepartment of Old Age Psychiatry, King's College London, Institute of Psychiatry, Psychology and Neuroscience, De Crespigny Park, London, SE5 8AF, UK.ORCID http://orcid.org/0000-0002-4214-9642
Simon J G LewisForeFront Parkinson's Disease Research Clinic, Brain and Mind Centre, School of Medical Sciences, University of Sydney, Camperdown, NSW, Australia.
Phil Hyu LeeYonsei University College of Medicine, Seoul, South Korea.
Seok Jong ChungYonsei University College of Medicine, Seoul, South Korea.
Rimona S WeilDementia Research Centre, University College London, 8-11 Queen Square, London, WC1M 3BG, UK.
Michele T HuOxford Parkinson's Disease Centre, Oxford, UK.
Clare E MackayOxford Parkinson's Disease Centre, Oxford, UK.
Ludovica GriffantiOxford Parkinson's Disease Centre, Oxford, UK.ORCID http://orcid.org/0000-0002-0540-9353
Delphine PinsUniv. Lille, Inserm, CHU Lille, U1172 - Centre Lille Neuroscience & Cognition, 59000, Lille, France.
Kathy DujardinUniv. Lille, Inserm, CHU Lille, U1172 - Centre Lille Neuroscience & Cognition, 59000, Lille, France.ORCID http://orcid.org/0000-0002-0110-574X
Renaud JardriUniv. Lille, Inserm, CHU Lille, U1172 - Centre Lille Neuroscience & Cognition, 59000, Lille, France.ORCID http://orcid.org/0000-0003-4596-1502
John-Paul TaylorNewcastle University, Translational and Clinical Research Institute, Biomedical Research Building, Campus for Ageing and Vitality, Newcastle Upon Tyne, NE4 5PL, UK.
Michael FirbankNewcastle University, Translational and Clinical Research Institute, Biomedical Research Building, Campus for Ageing and Vitality, Newcastle Upon Tyne, NE4 5PL, UK.ORCID http://orcid.org/0000-0002-9536-0185
Grainne McAlonanKing's College London, Institute of Psychiatry, Psychology and Neuroscience, De Crespigny Park, London, SE5 8AF, UK.
Henry K F MakDivision of Neurology, Dept of Medicine, LKS Faculty of Medicine, University of Hong Kong, Hong Kong, Hong Kong.ORCID http://orcid.org/0000-0002-2007-0650
Shu Leong HoDivision of Neurology, Dept of Medicine, LKS Faculty of Medicine, University of Hong Kong, Hong Kong, Hong Kong.
Mitul A MehtaDepartment of Neuroimaging, King's College London, Institute of Psychiatry, Psychology and Neuroscience, De Crespigny Park, London, SE5 8AF, UK.ORCID http://orcid.org/0000-0003-1152-5323
King's College London · GBInserm · FRUniversity of Oxford · GBChinese University of Hong Kong · HKNewcastle Hospitals - Campus for Ageing and Vitality · GBYonsei University · KRThe University of Sydney · AUWellcome Centre for Human Neuroimaging · GB

Funding

Department of HealthMedical Research Council MC_EX_MR/N50192X/1Medical Research Council MR/0059311Medical Research Council MR/M024962/1Medical Research Council MR/R005931/1Wellcome Trust
6 · The paper itself

Abstract

Parkinson's psychosis (PDP) describes a spectrum of symptoms that may arise in Parkinson's disease (PD) including visual hallucinations (VH). Imaging studies investigating the neural correlates of PDP have been inconsistent in their findings, due to differences in study design and limitations of scale. Here we use empirical Bayes harmonisation to pool together structural imaging data from multiple research groups into a large-scale mega-analysis, allowing us to identify cortical regions and networks involved in VH and their relation to receptor binding. Differences of morphometrics analysed show a wider cortical involvement underlying VH than previously recognised, including primary visual cortex and surrounding regions, and the hippocampus, independent of its role in cognitive decline. Structural covariance analyses point to the involvement of the attentional control networks in PD-VH, while associations with receptor density maps suggest neurotransmitter loss may be linked to the cortical changes.

Indexed as

Brain MappingHallucinationsParkinson DiseaseSensory Receptor CellsAgedBayes TheoremBrainCerebral CortexFemaleHippocampusHumansMaleMiddle Aged

Identifiers

PMID35082285
PMCPMC8791961
OpenAlexW4210783444

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.