Evidence map›Paper›PMID 35082273›Full record

ReviewTranslational psychiatry2022

7T ultra-high-field neuroimaging for mental health: an emerging tool for precision psychiatry?

Irene Neuner, Tanja Veselinović, Shukti Ramkiran, Ravichandran Rajkumar, Gereon Johannes Schnellbaecher, N Jon Shah

Abstract readReview
In one paragraph

Review in Translational psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Review
  5. Article
  6. Review
  7. Article
  8. Leveraging ultra-high field (7T) MRI in psychiatric research.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Review
  9. Neuroimaging Biomarkers in Addiction.medRxiv : the preprint server for health sciences · 2024
    Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. PET, SPECT, and MRI imaging for evaluation of Parkinson's disease.American journal of nuclear medicine and molecular imaging · 2024
    Review
  15. Article
  16. Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Irene Neuner *Institute of Neuroscience and Medicine 4, INM-4, Forschungszentrum Jülich, Jülich, Germany. i.neuner@fz-juelich.de.ORCID http://orcid.org/0000-0002-5164-8873
Tanja Veselinović *Institute of Neuroscience and Medicine 4, INM-4, Forschungszentrum Jülich, Jülich, Germany.ORCID http://orcid.org/0000-0001-7906-6966
Shukti RamkiranInstitute of Neuroscience and Medicine 4, INM-4, Forschungszentrum Jülich, Jülich, Germany.ORCID http://orcid.org/0000-0001-8253-1873
Ravichandran RajkumarInstitute of Neuroscience and Medicine 4, INM-4, Forschungszentrum Jülich, Jülich, Germany.ORCID http://orcid.org/0000-0001-5875-5316
Gereon Johannes SchnellbaecherInstitute of Neuroscience and Medicine 4, INM-4, Forschungszentrum Jülich, Jülich, Germany.
N Jon ShahInstitute of Neuroscience and Medicine 4, INM-4, Forschungszentrum Jülich, Jülich, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Given the huge symptom diversity and complexity of mental disorders, an individual approach is the most promising avenue for clinical transfer and the establishment of personalized psychiatry. However, due to technical limitations, knowledge about the neurobiological basis of mental illnesses has, to date, mainly been based on findings resulting from evaluations of average data from certain diagnostic groups. We postulate that this could change substantially through the use of the emerging ultra-high-field MRI (UHF-MRI) technology. The main advantages of UHF-MRI include high signal-to-noise ratio, resulting in higher spatial resolution and contrast and enabling individual examinations of single subjects. Thus, we used this technology to assess changes in the properties of resting-state networks over the course of therapy in a naturalistic study of two depressed patients. Significant changes in several network property measures were found in regions corresponding to prior knowledge from group-level studies. Moreover, relevant parameters were already significantly divergent in both patients at baseline. In summary, we demonstrate the feasibility of UHF-MRI for capturing individual neurobiological correlates of mental diseases. These could serve as a tool for therapy monitoring and pave the way for a truly individualized and predictive clinical approach in psychiatric care.

Indexed as

PsychiatryPsychotic DisordersHumansMagnetic Resonance ImagingMental HealthNeuroimaging

Identifiers

PMID35082273
PMCPMC8791951

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.