ArticleTranslational psychiatry2022
Immune marker levels in severe mental disorders: associations with polygenic risk scores of related mental phenotypes and psoriasis.
Article in Translational psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 27 citations in OpenAlex.
- Systematic Review and Meta-Analysis: Phenotypic Correlates of the Autism Polygenic Score.JAACAP open · 2025Article
- Optimizing genetic ancestry adjustment in DNA methylation studies: a comparative analysis of approaches.Epigenetics & chromatin · 2025Article
- A map of enhancer regions in primary human neural progenitor cells using capture STARR-seq.Genome research · 2025Article
- Temporal trends of blood-based markers in various psychiatric disorders and their cross-sectional brain structure associations.Communications medicine · 2025Article
- Linking Kawasaki Disease to Mental Health: A Nationwide Study on Long-Term Neurological Risks.Medicina (Kaunas, Lithuania) · 2025Article
- Depression and Anxiety in Patients with Psoriasis: A Comprehensive Analysis Combining Bibliometrics, Latent Dirichlet Allocation, and HJ-Biplot.Healthcare (Basel, Switzerland) · 2025Review
- Limited evidence of association between dysregulated immune marker levels and telomere length in severe mental disorders.Acta neuropsychiatrica · 2025Article
- Severe mental illness and infectious disease mortality: a systematic review and meta-analysis.EClinicalMedicine · 2024Article
- Unraveling COVID-19 relationship with anxiety disorders and symptoms using genome-wide data.Journal of affective disorders · 2024Article
- Incidence of oncogenic HPV infection in women with and without mental illness: A population-based cohort study in Sweden.PLoS medicine · 2024Article
- Triggers for the onset and recurrence of psoriasis: a review and update.Cell communication and signaling : CCS · 2024Review
- Cell-type deconvolution of bulk-blood RNA-seq reveals biological insights into neuropsychiatric disorders.American journal of human genetics · 2024Article
- [The importance of the human microbiome for mental health].Der Nervenarzt · 2023Review
- Disentangling the complexity of psoriasis in the post-genome-wide association era.Genes and immunity · 2023Review
- Postoperative C-Reactive Protein Predicts Postoperative Delirium in Colorectal Cancer Following Surgery.Clinical interventions in aging · 2023Article
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Authors and funding
15 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several lines of evidence implicate immune abnormalities in the pathophysiology of severe mental disorders (SMD) and comorbid mental disorders. Here, we use the data from genome-wide association studies (GWAS) of autoimmune diseases and mental phenotypes associated with SMD to disentangle genetic susceptibilities of immune abnormalities in SMD. We included 1004 patients with SMD and 947 healthy controls (HC) and measured plasma levels of IL-1Ra, sIL-2R, gp130, sTNFR-1, IL-18, APRIL, and ICAM-1. Polygenic risk scores (PRS) of six autoimmune disorders, CRP, and 10 SMD-related mental phenotypes were calculated from GWAS. General linear models were applied to assess the association of PRS with immune marker abnormalities. We found negative associations between PRS of educational attainment and IL-1Ra (P = 0.01) and IL-18 (P = 0.01). There were nominal positive associations between PRS of psoriasis and sgp130 (P = 0.02) and PRS of anxiety and IL-18 (P = 0.03), and nominal negative associations between PRS of anxiety and sIL-2R (P = 0.02) and PRS of educational attainment and sIL-2R (P = 0.03). Associations explained minor amounts of the immune marker plasma-level difference between SMD and HC. Different PRS and immune marker associations in the SMD group compared to HC were shown for PRS of extraversion and IL-1Ra ([interaction effect (IE), P = 0.002), and nominally for PRS of openness and IL-1Ra (IE, P = 0.02) and sTNFR-1 (IE, P = 0.04). Our findings indicate polygenic susceptibilities to immune abnormalities in SMD involving genetic overlap with SMD-related mental phenotypes and psoriasis. Associations might suggest immune genetic factors of SMD subgroups characterized by autoimmune or specific mental features.
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