Evidence map›Paper›PMID 35082171›Full record

ArticleNeurology2022

Intake of Flavonoids and Flavonoid-Rich Foods and Mortality Risk Among Individuals With Parkinson Disease: A Prospective Cohort Study.

Xinyuan Zhang, Samantha A Molsberry, Tian-Shin Yeh, Aedin Cassidy, Michael A Schwarzschild, Alberto Ascherio, Xiang Gao

Abstract read
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In one paragraph

Article in Neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
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  11. Review
  12. Review
  13. Flavonoid intake and risk of Parkinson's disease.Journal of neurology, neurosurgery, and psychiatry · 2024
    Article
  14. Epidemiology of Parkinson's Disease: An Update.Current neurology and neuroscience reports · 2024
    Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. The Role of Diet in Parkinson's Disease.Journal of Parkinson's disease · 2024
    Review
  20. Effect of Flavonoids against Parkinson's Disease.Central nervous system agents in medicinal chemistry · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xinyuan ZhangFrom the Department of Nutritional Sciences (X.Z., X.G.), Pennsylvania State University, University Park; Departments of Nutrition (S.A.M., T.-S.Y., A.A.) and Epidemiology (T.-S.Y., A.A.), Harvard T.H. Chan School of Public Health; Channing Division of Network Medicine (T.-S.Y., A.A.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Institute for Global Food Security (A.C.), Queen's University Belfast, Northern Ireland; and Department of Neurology (M.A.S.), Massachusetts General Hospital, Boston. Dr. Yeh is currently with Nuffield Department of Population Health, Big Data Institute, University of Oxford, UK.ORCID 0000-0002-2974-8392
Samantha A MolsberryFrom the Department of Nutritional Sciences (X.Z., X.G.), Pennsylvania State University, University Park; Departments of Nutrition (S.A.M., T.-S.Y., A.A.) and Epidemiology (T.-S.Y., A.A.), Harvard T.H. Chan School of Public Health; Channing Division of Network Medicine (T.-S.Y., A.A.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Institute for Global Food Security (A.C.), Queen's University Belfast, Northern Ireland; and Department of Neurology (M.A.S.), Massachusetts General Hospital, Boston. Dr. Yeh is currently with Nuffield Department of Population Health, Big Data Institute, University of Oxford, UK.
Tian-Shin YehFrom the Department of Nutritional Sciences (X.Z., X.G.), Pennsylvania State University, University Park; Departments of Nutrition (S.A.M., T.-S.Y., A.A.) and Epidemiology (T.-S.Y., A.A.), Harvard T.H. Chan School of Public Health; Channing Division of Network Medicine (T.-S.Y., A.A.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Institute for Global Food Security (A.C.), Queen's University Belfast, Northern Ireland; and Department of Neurology (M.A.S.), Massachusetts General Hospital, Boston. Dr. Yeh is currently with Nuffield Department of Population Health, Big Data Institute, University of Oxford, UK.
Aedin CassidyFrom the Department of Nutritional Sciences (X.Z., X.G.), Pennsylvania State University, University Park; Departments of Nutrition (S.A.M., T.-S.Y., A.A.) and Epidemiology (T.-S.Y., A.A.), Harvard T.H. Chan School of Public Health; Channing Division of Network Medicine (T.-S.Y., A.A.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Institute for Global Food Security (A.C.), Queen's University Belfast, Northern Ireland; and Department of Neurology (M.A.S.), Massachusetts General Hospital, Boston. Dr. Yeh is currently with Nuffield Department of Population Health, Big Data Institute, University of Oxford, UK.ORCID 0000-0003-0048-5602
Michael A SchwarzschildFrom the Department of Nutritional Sciences (X.Z., X.G.), Pennsylvania State University, University Park; Departments of Nutrition (S.A.M., T.-S.Y., A.A.) and Epidemiology (T.-S.Y., A.A.), Harvard T.H. Chan School of Public Health; Channing Division of Network Medicine (T.-S.Y., A.A.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Institute for Global Food Security (A.C.), Queen's University Belfast, Northern Ireland; and Department of Neurology (M.A.S.), Massachusetts General Hospital, Boston. Dr. Yeh is currently with Nuffield Department of Population Health, Big Data Institute, University of Oxford, UK.
Alberto AscherioFrom the Department of Nutritional Sciences (X.Z., X.G.), Pennsylvania State University, University Park; Departments of Nutrition (S.A.M., T.-S.Y., A.A.) and Epidemiology (T.-S.Y., A.A.), Harvard T.H. Chan School of Public Health; Channing Division of Network Medicine (T.-S.Y., A.A.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Institute for Global Food Security (A.C.), Queen's University Belfast, Northern Ireland; and Department of Neurology (M.A.S.), Massachusetts General Hospital, Boston. Dr. Yeh is currently with Nuffield Department of Population Health, Big Data Institute, University of Oxford, UK.
Xiang GaoFrom the Department of Nutritional Sciences (X.Z., X.G.), Pennsylvania State University, University Park; Departments of Nutrition (S.A.M., T.-S.Y., A.A.) and Epidemiology (T.-S.Y., A.A.), Harvard T.H. Chan School of Public Health; Channing Division of Network Medicine (T.-S.Y., A.A.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Institute for Global Food Security (A.C.), Queen's University Belfast, Northern Ireland; and Department of Neurology (M.A.S.), Massachusetts General Hospital, Boston. Dr. Yeh is currently with Nuffield Department of Population Health, Big Data Institute, University of Oxford, UK. xxg14@psu.edu.ORCID 0000-0003-2617-6509

Funding

Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3M
Cancer Epidemiology Cohort in Male Health ProfessionalsU01CA167552 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Lorelei Mucci, Walter C. Willett · 2017 to 2026
$17.0M
MC1R Basis of Melanoma-Parkinson's Link and Neuroprotective Potential of MC1RR01NS102735 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI CHEN, XIQUN · 2018 to 2022
$1.8M
NCI NIH HHS U01 CA167552NCI NIH HHS UM1 CA186107NINDS NIH HHS R01 NS102735
6 · The paper itself

Abstract

BACKGROUND AND

objectivesAlthough flavonoids have the potential to exert neuroprotective benefits, evidence of their role in improving survival rates among individuals with Parkinson disease (PD) remains lacking. We aimed to prospectively study the association between prediagnosis and postdiagnosis flavonoid intakes and risk of mortality among individuals with PD identified from 2 large ongoing cohorts of US men and women.

methodsIncluded in the current analysis were 599 women from the Nurses' Health Study and 652 men from the Health Professionals Follow-Up Study who were newly diagnosed with PD during follow-up. Dietary intakes of total flavonoid and its subclasses, together with major flavonoid-rich foods (tea, apples, berries, orange and orange juice, and red wine), were repeatedly assessed with a validated food frequency questionnaire every 4 years. Mortality was ascertained via the National Death Index and state vital statistics records.

resultsWe documented 944 deaths during 32 to 34 years of follow-up. A higher total flavonoid intake before PD diagnosis was associated with a lower future risk for all-cause mortality in men (hazard ratio [HR] comparing 2 extreme quartiles 0.53, 95% confidence interval [CI] 0.39, 0.71; DISCUSSION: Among individuals with PD, higher consumption of flavonoids, especially anthocyanins and flavan-3-ols, and flavonoid-rich food such as berries and red wine was likely to be associated with a lower risk of mortality.

Indexed as

FlavonoidsParkinson DiseaseAnthocyaninsDietFemaleFollow-Up StudiesHumansMaleProspective StudiesAnthocyaninsFlavonoids

Identifiers

PMID35082171
PMCPMC8967390

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.