Evidence map›Paper›PMID 35082170›Full record

ArticleNeurology2022

Costs and Health-Related Quality of Life in Patients With NMO Spectrum Disorders and MOG-Antibody-Associated Disease: CHANCE

Martin W Hümmert, Louisa M Schöppe, Judith Bellmann-Strobl, Nadja Siebert, Friedemann Paul, Ankelien Duchow, Hannah Pellkofer, Tania Kümpfel, Joachim Havla, Sven Jarius and 23 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
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  18. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors.

Martin W HümmertFrom the Department of Neurology (M.W.H., L.M.S., M. Stangle, S.G., O.S.-K., C.T.), Hannover Medical School; NeuroCure Clinical Research Center (J.B.-S, N.S., F.P., A.D.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, and Max Delbrück Center for Molecular Medicine; Experimental and Clinical Research Center (J.B.-S., N.S., F.P., A.D.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin; Department of Neurology (F.P.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health; Institute of Clinical Neuroimmunology (H.P., T.K., J.H.), LMU Hospital, Ludwig-Maximilians Universität München, Munich; Institute of Neuropathology (H.P., M.S.W.), Department of Neurology, University Medical Center Göttingen; Molecular Neuroimmunology Group (S.J., B.W.), Department of Neurology, University of Heidelberg; Department of Neurology (A.B.), School of Medicine, Technical University Munich, Klinikum rechts der Isar; Department of Neurology (F.T.B.), University of Leipzig; Department of Neurology (M.P., L.K.), University of Münster; Department of Neurology (M.P.), Otto-von-Guericke University of Magdeburg; Marianne-Strauß-Klinik (I.K.), Behandlungszentrum Kempfenhausen für Multiple Sklerose Kranke, Berg; Department of Neurology (I.K., K.H., I.A.), St. Josef Hospital, Ruhr University Bochum; Department of Neurology (J.H.F.), Asklepios Expert Clinic Teupitz; Department of Neurology (R.P.), University of Essen; Department of Neurology (A.W.), Herford Hospital; Neuroimmunological Section (U.K.Z.), Department of Neurology, University of Rostock; Department of Neurology (M. Senel), University of Ulm; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (J.-P.S., V.H.), University Medical Center Hamburg-Eppendorf, Germany; 20. Aix-Marseille Univ (J.-P.S.), CNRS, CRMBM, UMR 7339; APHM (J.-P.S.), Hopital de la Timone, CEMEREM, Marseille, France; I.M. Sechenov First Moscow State Medical University (I.A.), Moscow, Russia; and Department of Neurology (O.A., M.R.), Medical Faculty, and Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich Heine University Düsseldorf, Germany.ORCID 0000-0002-5928-2343
Louisa M SchöppeFrom the Department of Neurology (M.W.H., L.M.S., M. Stangle, S.G., O.S.-K., C.T.), Hannover Medical School; NeuroCure Clinical Research Center (J.B.-S, N.S., F.P., A.D.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, and Max Delbrück Center for Molecular Medicine; Experimental and Clinical Research Center (J.B.-S., N.S., F.P., A.D.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin; Department of Neurology (F.P.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health; Institute of Clinical Neuroimmunology (H.P., T.K., J.H.), LMU Hospital, Ludwig-Maximilians Universität München, Munich; Institute of Neuropathology (H.P., M.S.W.), Department of Neurology, University Medical Center Göttingen; Molecular Neuroimmunology Group (S.J., B.W.), Department of Neurology, University of Heidelberg; Department of Neurology (A.B.), School of Medicine, Technical University Munich, Klinikum rechts der Isar; Department of Neurology (F.T.B.), University of Leipzig; Department of Neurology (M.P., L.K.), University of Münster; Department of Neurology (M.P.), Otto-von-Guericke University of Magdeburg; Marianne-Strauß-Klinik (I.K.), Behandlungszentrum Kempfenhausen für Multiple Sklerose Kranke, Berg; Department of Neurology (I.K., K.H., I.A.), St. Josef Hospital, Ruhr University Bochum; Department of Neurology (J.H.F.), Asklepios Expert Clinic Teupitz; Department of Neurology (R.P.), University of Essen; Department of Neurology (A.W.), Herford Hospital; Neuroimmunological Section (U.K.Z.), Department of Neurology, University of Rostock; Department of Neurology (M. Senel), University of Ulm; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (J.-P.S., V.H.), University Medical Center Hamburg-Eppendorf, Germany; 20. Aix-Marseille Univ (J.-P.S.), CNRS, CRMBM, UMR 7339; APHM (J.-P.S.), Hopital de la Timone, CEMEREM, Marseille, France; I.M. Sechenov First Moscow State Medical University (I.A.), Moscow, Russia; and Department of Neurology (O.A., M.R.), Medical Faculty, and Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich Heine University Düsseldorf, Germany.
Judith Bellmann-StroblFrom the Department of Neurology (M.W.H., L.M.S., M. Stangle, S.G., O.S.-K., C.T.), Hannover Medical School; NeuroCure Clinical Research Center (J.B.-S, N.S., F.P., A.D.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, and Max Delbrück Center for Molecular Medicine; Experimental and Clinical Research Center (J.B.-S., N.S., F.P., A.D.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin; Department of Neurology (F.P.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health; Institute of Clinical Neuroimmunology (H.P., T.K., J.H.), LMU Hospital, Ludwig-Maximilians Universität München, Munich; Institute of Neuropathology (H.P., M.S.W.), Department of Neurology, University Medical Center Göttingen; Molecular Neuroimmunology Group (S.J., B.W.), Department of Neurology, University of Heidelberg; Department of Neurology (A.B.), School of Medicine, Technical University Munich, Klinikum rechts der Isar; Department of Neurology (F.T.B.), University of Leipzig; Department of Neurology (M.P., L.K.), University of Münster; Department of Neurology (M.P.), Otto-von-Guericke University of Magdeburg; Marianne-Strauß-Klinik (I.K.), Behandlungszentrum Kempfenhausen für Multiple Sklerose Kranke, Berg; Department of Neurology (I.K., K.H., I.A.), St. Josef Hospital, Ruhr University Bochum; Department of Neurology (J.H.F.), Asklepios Expert Clinic Teupitz; Department of Neurology (R.P.), University of Essen; Department of Neurology (A.W.), Herford Hospital; Neuroimmunological Section (U.K.Z.), Department of Neurology, University of Rostock; Department of Neurology (M. Senel), University of Ulm; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (J.-P.S., V.H.), University Medical Center Hamburg-Eppendorf, Germany; 20. Aix-Marseille Univ (J.-P.S.), CNRS, CRMBM, UMR 7339; APHM (J.-P.S.), Hopital de la Timone, CEMEREM, Marseille, France; I.M. Sechenov First Moscow State Medical University (I.A.), Moscow, Russia; and Department of Neurology (O.A., M.R.), Medical Faculty, and Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich Heine University Düsseldorf, Germany.ORCID 0000-0003-2615-1643
Nadja SiebertFrom the Department of Neurology (M.W.H., L.M.S., M. Stangle, S.G., O.S.-K., C.T.), Hannover Medical School; NeuroCure Clinical Research Center (J.B.-S, N.S., F.P., A.D.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, and Max Delbrück Center for Molecular Medicine; Experimental and Clinical Research Center (J.B.-S., N.S., F.P., A.D.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin; Department of Neurology (F.P.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health; Institute of Clinical Neuroimmunology (H.P., T.K., J.H.), LMU Hospital, Ludwig-Maximilians Universität München, Munich; Institute of Neuropathology (H.P., M.S.W.), Department of Neurology, University Medical Center Göttingen; Molecular Neuroimmunology Group (S.J., B.W.), Department of Neurology, University of Heidelberg; Department of Neurology (A.B.), School of Medicine, Technical University Munich, Klinikum rechts der Isar; Department of Neurology (F.T.B.), University of Leipzig; Department of Neurology (M.P., L.K.), University of Münster; Department of Neurology (M.P.), Otto-von-Guericke University of Magdeburg; Marianne-Strauß-Klinik (I.K.), Behandlungszentrum Kempfenhausen für Multiple Sklerose Kranke, Berg; Department of Neurology (I.K., K.H., I.A.), St. Josef Hospital, Ruhr University Bochum; Department of Neurology (J.H.F.), Asklepios Expert Clinic Teupitz; Department of Neurology (R.P.), University of Essen; Department of Neurology (A.W.), Herford Hospital; Neuroimmunological Section (U.K.Z.), Department of Neurology, University of Rostock; Department of Neurology (M. Senel), University of Ulm; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (J.-P.S., V.H.), University Medical Center Hamburg-Eppendorf, Germany; 20. Aix-Marseille Univ (J.-P.S.), CNRS, CRMBM, UMR 7339; APHM (J.-P.S.), Hopital de la Timone, CEMEREM, Marseille, France; I.M. Sechenov First Moscow State Medical University (I.A.), Moscow, Russia; and Department of Neurology (O.A., M.R.), Medical Faculty, and Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich Heine University Düsseldorf, Germany.
Friedemann PaulFrom the Department of Neurology (M.W.H., L.M.S., M. Stangle, S.G., O.S.-K., C.T.), Hannover Medical School; NeuroCure Clinical Research Center (J.B.-S, N.S., F.P., A.D.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, and Max Delbrück Center for Molecular Medicine; Experimental and Clinical Research Center (J.B.-S., N.S., F.P., A.D.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin; Department of Neurology (F.P.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health; Institute of Clinical Neuroimmunology (H.P., T.K., J.H.), LMU Hospital, Ludwig-Maximilians Universität München, Munich; Institute of Neuropathology (H.P., M.S.W.), Department of Neurology, University Medical Center Göttingen; Molecular Neuroimmunology Group (S.J., B.W.), Department of Neurology, University of Heidelberg; Department of Neurology (A.B.), School of Medicine, Technical University Munich, Klinikum rechts der Isar; Department of Neurology (F.T.B.), University of Leipzig; Department of Neurology (M.P., L.K.), University of Münster; Department of Neurology (M.P.), Otto-von-Guericke University of Magdeburg; Marianne-Strauß-Klinik (I.K.), Behandlungszentrum Kempfenhausen für Multiple Sklerose Kranke, Berg; Department of Neurology (I.K., K.H., I.A.), St. Josef Hospital, Ruhr University Bochum; Department of Neurology (J.H.F.), Asklepios Expert Clinic Teupitz; Department of Neurology (R.P.), University of Essen; Department of Neurology (A.W.), Herford Hospital; Neuroimmunological Section (U.K.Z.), Department of Neurology, University of Rostock; Department of Neurology (M. Senel), University of Ulm; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (J.-P.S., V.H.), University Medical Center Hamburg-Eppendorf, Germany; 20. Aix-Marseille Univ (J.-P.S.), CNRS, CRMBM, UMR 7339; APHM (J.-P.S.), Hopital de la Timone, CEMEREM, Marseille, France; I.M. Sechenov First Moscow State Medical University (I.A.), Moscow, Russia; and Department of Neurology (O.A., M.R.), Medical Faculty, and Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich Heine University Düsseldorf, Germany.
Ankelien DuchowFrom the Department of Neurology (M.W.H., L.M.S., M. Stangle, S.G., O.S.-K., C.T.), Hannover Medical School; NeuroCure Clinical Research Center (J.B.-S, N.S., F.P., A.D.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, and Max Delbrück Center for Molecular Medicine; Experimental and Clinical Research Center (J.B.-S., N.S., F.P., A.D.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin; Department of Neurology (F.P.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health; Institute of Clinical Neuroimmunology (H.P., T.K., J.H.), LMU Hospital, Ludwig-Maximilians Universität München, Munich; Institute of Neuropathology (H.P., M.S.W.), Department of Neurology, University Medical Center Göttingen; Molecular Neuroimmunology Group (S.J., B.W.), Department of Neurology, University of Heidelberg; Department of Neurology (A.B.), School of Medicine, Technical University Munich, Klinikum rechts der Isar; Department of Neurology (F.T.B.), University of Leipzig; Department of Neurology (M.P., L.K.), University of Münster; Department of Neurology (M.P.), Otto-von-Guericke University of Magdeburg; Marianne-Strauß-Klinik (I.K.), Behandlungszentrum Kempfenhausen für Multiple Sklerose Kranke, Berg; Department of Neurology (I.K., K.H., I.A.), St. Josef Hospital, Ruhr University Bochum; Department of Neurology (J.H.F.), Asklepios Expert Clinic Teupitz; Department of Neurology (R.P.), University of Essen; Department of Neurology (A.W.), Herford Hospital; Neuroimmunological Section (U.K.Z.), Department of Neurology, University of Rostock; Department of Neurology (M. Senel), University of Ulm; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (J.-P.S., V.H.), University Medical Center Hamburg-Eppendorf, Germany; 20. Aix-Marseille Univ (J.-P.S.), CNRS, CRMBM, UMR 7339; APHM (J.-P.S.), Hopital de la Timone, CEMEREM, Marseille, France; I.M. Sechenov First Moscow State Medical University (I.A.), Moscow, Russia; and Department of Neurology (O.A., M.R.), Medical Faculty, and Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich Heine University Düsseldorf, Germany.ORCID 0000-0003-0854-7521
Hannah PellkoferFrom the Department of Neurology (M.W.H., L.M.S., M. Stangle, S.G., O.S.-K., C.T.), Hannover Medical School; NeuroCure Clinical Research Center (J.B.-S, N.S., F.P., A.D.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, and Max Delbrück Center for Molecular Medicine; Experimental and Clinical Research Center (J.B.-S., N.S., F.P., A.D.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin; Department of Neurology (F.P.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health; Institute of Clinical Neuroimmunology (H.P., T.K., J.H.), LMU Hospital, Ludwig-Maximilians Universität München, Munich; Institute of Neuropathology (H.P., M.S.W.), Department of Neurology, University Medical Center Göttingen; Molecular Neuroimmunology Group (S.J., B.W.), Department of Neurology, University of Heidelberg; Department of Neurology (A.B.), School of Medicine, Technical University Munich, Klinikum rechts der Isar; Department of Neurology (F.T.B.), University of Leipzig; Department of Neurology (M.P., L.K.), University of Münster; Department of Neurology (M.P.), Otto-von-Guericke University of Magdeburg; Marianne-Strauß-Klinik (I.K.), Behandlungszentrum Kempfenhausen für Multiple Sklerose Kranke, Berg; Department of Neurology (I.K., K.H., I.A.), St. Josef Hospital, Ruhr University Bochum; Department of Neurology (J.H.F.), Asklepios Expert Clinic Teupitz; Department of Neurology (R.P.), University of Essen; Department of Neurology (A.W.), Herford Hospital; Neuroimmunological Section (U.K.Z.), Department of Neurology, University of Rostock; Department of Neurology (M. Senel), University of Ulm; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (J.-P.S., V.H.), University Medical Center Hamburg-Eppendorf, Germany; 20. Aix-Marseille Univ (J.-P.S.), CNRS, CRMBM, UMR 7339; APHM (J.-P.S.), Hopital de la Timone, CEMEREM, Marseille, France; I.M. Sechenov First Moscow State Medical University (I.A.), Moscow, Russia; and Department of Neurology (O.A., M.R.), Medical Faculty, and Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich Heine University Düsseldorf, Germany.
Tania KümpfelFrom the Department of Neurology (M.W.H., L.M.S., M. Stangle, S.G., O.S.-K., C.T.), Hannover Medical School; NeuroCure Clinical Research Center (J.B.-S, N.S., F.P., A.D.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, and Max Delbrück Center for Molecular Medicine; Experimental and Clinical Research Center (J.B.-S., N.S., F.P., A.D.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin; Department of Neurology (F.P.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health; Institute of Clinical Neuroimmunology (H.P., T.K., J.H.), LMU Hospital, Ludwig-Maximilians Universität München, Munich; Institute of Neuropathology (H.P., M.S.W.), Department of Neurology, University Medical Center Göttingen; Molecular Neuroimmunology Group (S.J., B.W.), Department of Neurology, University of Heidelberg; Department of Neurology (A.B.), School of Medicine, Technical University Munich, Klinikum rechts der Isar; Department of Neurology (F.T.B.), University of Leipzig; Department of Neurology (M.P., L.K.), University of Münster; Department of Neurology (M.P.), Otto-von-Guericke University of Magdeburg; Marianne-Strauß-Klinik (I.K.), Behandlungszentrum Kempfenhausen für Multiple Sklerose Kranke, Berg; Department of Neurology (I.K., K.H., I.A.), St. Josef Hospital, Ruhr University Bochum; Department of Neurology (J.H.F.), Asklepios Expert Clinic Teupitz; Department of Neurology (R.P.), University of Essen; Department of Neurology (A.W.), Herford Hospital; Neuroimmunological Section (U.K.Z.), Department of Neurology, University of Rostock; Department of Neurology (M. Senel), University of Ulm; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (J.-P.S., V.H.), University Medical Center Hamburg-Eppendorf, Germany; 20. Aix-Marseille Univ (J.-P.S.), CNRS, CRMBM, UMR 7339; APHM (J.-P.S.), Hopital de la Timone, CEMEREM, Marseille, France; I.M. Sechenov First Moscow State Medical University (I.A.), Moscow, Russia; and Department of Neurology (O.A., M.R.), Medical Faculty, and Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich Heine University Düsseldorf, Germany.
Joachim HavlaFrom the Department of Neurology (M.W.H., L.M.S., M. Stangle, S.G., O.S.-K., C.T.), Hannover Medical School; NeuroCure Clinical Research Center (J.B.-S, N.S., F.P., A.D.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, and Max Delbrück Center for Molecular Medicine; Experimental and Clinical Research Center (J.B.-S., N.S., F.P., A.D.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin; Department of Neurology (F.P.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health; Institute of Clinical Neuroimmunology (H.P., T.K., J.H.), LMU Hospital, Ludwig-Maximilians Universität München, Munich; Institute of Neuropathology (H.P., M.S.W.), Department of Neurology, University Medical Center Göttingen; Molecular Neuroimmunology Group (S.J., B.W.), Department of Neurology, University of Heidelberg; Department of Neurology (A.B.), School of Medicine, Technical University Munich, Klinikum rechts der Isar; Department of Neurology (F.T.B.), University of Leipzig; Department of Neurology (M.P., L.K.), University of Münster; Department of Neurology (M.P.), Otto-von-Guericke University of Magdeburg; Marianne-Strauß-Klinik (I.K.), Behandlungszentrum Kempfenhausen für Multiple Sklerose Kranke, Berg; Department of Neurology (I.K., K.H., I.A.), St. Josef Hospital, Ruhr University Bochum; Department of Neurology (J.H.F.), Asklepios Expert Clinic Teupitz; Department of Neurology (R.P.), University of Essen; Department of Neurology (A.W.), Herford Hospital; Neuroimmunological Section (U.K.Z.), Department of Neurology, University of Rostock; Department of Neurology (M. Senel), University of Ulm; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (J.-P.S., V.H.), University Medical Center Hamburg-Eppendorf, Germany; 20. Aix-Marseille Univ (J.-P.S.), CNRS, CRMBM, UMR 7339; APHM (J.-P.S.), Hopital de la Timone, CEMEREM, Marseille, France; I.M. Sechenov First Moscow State Medical University (I.A.), Moscow, Russia; and Department of Neurology (O.A., M.R.), Medical Faculty, and Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich Heine University Düsseldorf, Germany.ORCID 0000-0002-4386-1340
Sven JariusFrom the Department of Neurology (M.W.H., L.M.S., M. Stangle, S.G., O.S.-K., C.T.), Hannover Medical School; NeuroCure Clinical Research Center (J.B.-S, N.S., F.P., A.D.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, and Max Delbrück Center for Molecular Medicine; Experimental and Clinical Research Center (J.B.-S., N.S., F.P., A.D.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin; Department of Neurology (F.P.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health; Institute of Clinical Neuroimmunology (H.P., T.K., J.H.), LMU Hospital, Ludwig-Maximilians Universität München, Munich; Institute of Neuropathology (H.P., M.S.W.), Department of Neurology, University Medical Center Göttingen; Molecular Neuroimmunology Group (S.J., B.W.), Department of Neurology, University of Heidelberg; Department of Neurology (A.B.), School of Medicine, Technical University Munich, Klinikum rechts der Isar; Department of Neurology (F.T.B.), University of Leipzig; Department of Neurology (M.P., L.K.), University of Münster; Department of Neurology (M.P.), Otto-von-Guericke University of Magdeburg; Marianne-Strauß-Klinik (I.K.), Behandlungszentrum Kempfenhausen für Multiple Sklerose Kranke, Berg; Department of Neurology (I.K., K.H., I.A.), St. Josef Hospital, Ruhr University Bochum; Department of Neurology (J.H.F.), Asklepios Expert Clinic Teupitz; Department of Neurology (R.P.), University of Essen; Department of Neurology (A.W.), Herford Hospital; Neuroimmunological Section (U.K.Z.), Department of Neurology, University of Rostock; Department of Neurology (M. Senel), University of Ulm; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (J.-P.S., V.H.), University Medical Center Hamburg-Eppendorf, Germany; 20. Aix-Marseille Univ (J.-P.S.), CNRS, CRMBM, UMR 7339; APHM (J.-P.S.), Hopital de la Timone, CEMEREM, Marseille, France; I.M. Sechenov First Moscow State Medical University (I.A.), Moscow, Russia; and Department of Neurology (O.A., M.R.), Medical Faculty, and Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich Heine University Düsseldorf, Germany.
Brigitte WildemannFrom the Department of Neurology (M.W.H., L.M.S., M. Stangle, S.G., O.S.-K., C.T.), Hannover Medical School; NeuroCure Clinical Research Center (J.B.-S, N.S., F.P., A.D.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, and Max Delbrück Center for Molecular Medicine; Experimental and Clinical Research Center (J.B.-S., N.S., F.P., A.D.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin; Department of Neurology (F.P.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health; Institute of Clinical Neuroimmunology (H.P., T.K., J.H.), LMU Hospital, Ludwig-Maximilians Universität München, Munich; Institute of Neuropathology (H.P., M.S.W.), Department of Neurology, University Medical Center Göttingen; Molecular Neuroimmunology Group (S.J., B.W.), Department of Neurology, University of Heidelberg; Department of Neurology (A.B.), School of Medicine, Technical University Munich, Klinikum rechts der Isar; Department of Neurology (F.T.B.), University of Leipzig; Department of Neurology (M.P., L.K.), University of Münster; Department of Neurology (M.P.), Otto-von-Guericke University of Magdeburg; Marianne-Strauß-Klinik (I.K.), Behandlungszentrum Kempfenhausen für Multiple Sklerose Kranke, Berg; Department of Neurology (I.K., K.H., I.A.), St. Josef Hospital, Ruhr University Bochum; Department of Neurology (J.H.F.), Asklepios Expert Clinic Teupitz; Department of Neurology (R.P.), University of Essen; Department of Neurology (A.W.), Herford Hospital; Neuroimmunological Section (U.K.Z.), Department of Neurology, University of Rostock; Department of Neurology (M. Senel), University of Ulm; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (J.-P.S., V.H.), University Medical Center Hamburg-Eppendorf, Germany; 20. Aix-Marseille Univ (J.-P.S.), CNRS, CRMBM, UMR 7339; APHM (J.-P.S.), Hopital de la Timone, CEMEREM, Marseille, France; I.M. Sechenov First Moscow State Medical University (I.A.), Moscow, Russia; and Department of Neurology (O.A., M.R.), Medical Faculty, and Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich Heine University Düsseldorf, Germany.
Achim BertheleFrom the Department of Neurology (M.W.H., L.M.S., M. Stangle, S.G., O.S.-K., C.T.), Hannover Medical School; NeuroCure Clinical Research Center (J.B.-S, N.S., F.P., A.D.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, and Max Delbrück Center for Molecular Medicine; Experimental and Clinical Research Center (J.B.-S., N.S., F.P., A.D.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin; Department of Neurology (F.P.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health; Institute of Clinical Neuroimmunology (H.P., T.K., J.H.), LMU Hospital, Ludwig-Maximilians Universität München, Munich; Institute of Neuropathology (H.P., M.S.W.), Department of Neurology, University Medical Center Göttingen; Molecular Neuroimmunology Group (S.J., B.W.), Department of Neurology, University of Heidelberg; Department of Neurology (A.B.), School of Medicine, Technical University Munich, Klinikum rechts der Isar; Department of Neurology (F.T.B.), University of Leipzig; Department of Neurology (M.P., L.K.), University of Münster; Department of Neurology (M.P.), Otto-von-Guericke University of Magdeburg; Marianne-Strauß-Klinik (I.K.), Behandlungszentrum Kempfenhausen für Multiple Sklerose Kranke, Berg; Department of Neurology (I.K., K.H., I.A.), St. Josef Hospital, Ruhr University Bochum; Department of Neurology (J.H.F.), Asklepios Expert Clinic Teupitz; Department of Neurology (R.P.), University of Essen; Department of Neurology (A.W.), Herford Hospital; Neuroimmunological Section (U.K.Z.), Department of Neurology, University of Rostock; Department of Neurology (M. Senel), University of Ulm; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (J.-P.S., V.H.), University Medical Center Hamburg-Eppendorf, Germany; 20. Aix-Marseille Univ (J.-P.S.), CNRS, CRMBM, UMR 7339; APHM (J.-P.S.), Hopital de la Timone, CEMEREM, Marseille, France; I.M. Sechenov First Moscow State Medical University (I.A.), Moscow, Russia; and Department of Neurology (O.A., M.R.), Medical Faculty, and Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich Heine University Düsseldorf, Germany.ORCID 0000-0001-9650-6222
Florian Then BerghFrom the Department of Neurology (M.W.H., L.M.S., M. Stangle, S.G., O.S.-K., C.T.), Hannover Medical School; NeuroCure Clinical Research Center (J.B.-S, N.S., F.P., A.D.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, and Max Delbrück Center for Molecular Medicine; Experimental and Clinical Research Center (J.B.-S., N.S., F.P., A.D.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin; Department of Neurology (F.P.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health; Institute of Clinical Neuroimmunology (H.P., T.K., J.H.), LMU Hospital, Ludwig-Maximilians Universität München, Munich; Institute of Neuropathology (H.P., M.S.W.), Department of Neurology, University Medical Center Göttingen; Molecular Neuroimmunology Group (S.J., B.W.), Department of Neurology, University of Heidelberg; Department of Neurology (A.B.), School of Medicine, Technical University Munich, Klinikum rechts der Isar; Department of Neurology (F.T.B.), University of Leipzig; Department of Neurology (M.P., L.K.), University of Münster; Department of Neurology (M.P.), Otto-von-Guericke University of Magdeburg; Marianne-Strauß-Klinik (I.K.), Behandlungszentrum Kempfenhausen für Multiple Sklerose Kranke, Berg; Department of Neurology (I.K., K.H., I.A.), St. Josef Hospital, Ruhr University Bochum; Department of Neurology (J.H.F.), Asklepios Expert Clinic Teupitz; Department of Neurology (R.P.), University of Essen; Department of Neurology (A.W.), Herford Hospital; Neuroimmunological Section (U.K.Z.), Department of Neurology, University of Rostock; Department of Neurology (M. Senel), University of Ulm; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (J.-P.S., V.H.), University Medical Center Hamburg-Eppendorf, Germany; 20. Aix-Marseille Univ (J.-P.S.), CNRS, CRMBM, UMR 7339; APHM (J.-P.S.), Hopital de la Timone, CEMEREM, Marseille, France; I.M. Sechenov First Moscow State Medical University (I.A.), Moscow, Russia; and Department of Neurology (O.A., M.R.), Medical Faculty, and Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich Heine University Düsseldorf, Germany.
Marc PawlitzkiFrom the Department of Neurology (M.W.H., L.M.S., M. Stangle, S.G., O.S.-K., C.T.), Hannover Medical School; NeuroCure Clinical Research Center (J.B.-S, N.S., F.P., A.D.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, and Max Delbrück Center for Molecular Medicine; Experimental and Clinical Research Center (J.B.-S., N.S., F.P., A.D.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin; Department of Neurology (F.P.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health; Institute of Clinical Neuroimmunology (H.P., T.K., J.H.), LMU Hospital, Ludwig-Maximilians Universität München, Munich; Institute of Neuropathology (H.P., M.S.W.), Department of Neurology, University Medical Center Göttingen; Molecular Neuroimmunology Group (S.J., B.W.), Department of Neurology, University of Heidelberg; Department of Neurology (A.B.), School of Medicine, Technical University Munich, Klinikum rechts der Isar; Department of Neurology (F.T.B.), University of Leipzig; Department of Neurology (M.P., L.K.), University of Münster; Department of Neurology (M.P.), Otto-von-Guericke University of Magdeburg; Marianne-Strauß-Klinik (I.K.), Behandlungszentrum Kempfenhausen für Multiple Sklerose Kranke, Berg; Department of Neurology (I.K., K.H., I.A.), St. Josef Hospital, Ruhr University Bochum; Department of Neurology (J.H.F.), Asklepios Expert Clinic Teupitz; Department of Neurology (R.P.), University of Essen; Department of Neurology (A.W.), Herford Hospital; Neuroimmunological Section (U.K.Z.), Department of Neurology, University of Rostock; Department of Neurology (M. Senel), University of Ulm; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (J.-P.S., V.H.), University Medical Center Hamburg-Eppendorf, Germany; 20. Aix-Marseille Univ (J.-P.S.), CNRS, CRMBM, UMR 7339; APHM (J.-P.S.), Hopital de la Timone, CEMEREM, Marseille, France; I.M. Sechenov First Moscow State Medical University (I.A.), Moscow, Russia; and Department of Neurology (O.A., M.R.), Medical Faculty, and Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich Heine University Düsseldorf, Germany.
Luisa KlotzFrom the Department of Neurology (M.W.H., L.M.S., M. Stangle, S.G., O.S.-K., C.T.), Hannover Medical School; NeuroCure Clinical Research Center (J.B.-S, N.S., F.P., A.D.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, and Max Delbrück Center for Molecular Medicine; Experimental and Clinical Research Center (J.B.-S., N.S., F.P., A.D.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin; Department of Neurology (F.P.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health; Institute of Clinical Neuroimmunology (H.P., T.K., J.H.), LMU Hospital, Ludwig-Maximilians Universität München, Munich; Institute of Neuropathology (H.P., M.S.W.), Department of Neurology, University Medical Center Göttingen; Molecular Neuroimmunology Group (S.J., B.W.), Department of Neurology, University of Heidelberg; Department of Neurology (A.B.), School of Medicine, Technical University Munich, Klinikum rechts der Isar; Department of Neurology (F.T.B.), University of Leipzig; Department of Neurology (M.P., L.K.), University of Münster; Department of Neurology (M.P.), Otto-von-Guericke University of Magdeburg; Marianne-Strauß-Klinik (I.K.), Behandlungszentrum Kempfenhausen für Multiple Sklerose Kranke, Berg; Department of Neurology (I.K., K.H., I.A.), St. Josef Hospital, Ruhr University Bochum; Department of Neurology (J.H.F.), Asklepios Expert Clinic Teupitz; Department of Neurology (R.P.), University of Essen; Department of Neurology (A.W.), Herford Hospital; Neuroimmunological Section (U.K.Z.), Department of Neurology, University of Rostock; Department of Neurology (M. Senel), University of Ulm; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (J.-P.S., V.H.), University Medical Center Hamburg-Eppendorf, Germany; 20. Aix-Marseille Univ (J.-P.S.), CNRS, CRMBM, UMR 7339; APHM (J.-P.S.), Hopital de la Timone, CEMEREM, Marseille, France; I.M. Sechenov First Moscow State Medical University (I.A.), Moscow, Russia; and Department of Neurology (O.A., M.R.), Medical Faculty, and Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich Heine University Düsseldorf, Germany.ORCID 0000-0001-5439-9633
Ingo KleiterFrom the Department of Neurology (M.W.H., L.M.S., M. Stangle, S.G., O.S.-K., C.T.), Hannover Medical School; NeuroCure Clinical Research Center (J.B.-S, N.S., F.P., A.D.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, and Max Delbrück Center for Molecular Medicine; Experimental and Clinical Research Center (J.B.-S., N.S., F.P., A.D.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin; Department of Neurology (F.P.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health; Institute of Clinical Neuroimmunology (H.P., T.K., J.H.), LMU Hospital, Ludwig-Maximilians Universität München, Munich; Institute of Neuropathology (H.P., M.S.W.), Department of Neurology, University Medical Center Göttingen; Molecular Neuroimmunology Group (S.J., B.W.), Department of Neurology, University of Heidelberg; Department of Neurology (A.B.), School of Medicine, Technical University Munich, Klinikum rechts der Isar; Department of Neurology (F.T.B.), University of Leipzig; Department of Neurology (M.P., L.K.), University of Münster; Department of Neurology (M.P.), Otto-von-Guericke University of Magdeburg; Marianne-Strauß-Klinik (I.K.), Behandlungszentrum Kempfenhausen für Multiple Sklerose Kranke, Berg; Department of Neurology (I.K., K.H., I.A.), St. Josef Hospital, Ruhr University Bochum; Department of Neurology (J.H.F.), Asklepios Expert Clinic Teupitz; Department of Neurology (R.P.), University of Essen; Department of Neurology (A.W.), Herford Hospital; Neuroimmunological Section (U.K.Z.), Department of Neurology, University of Rostock; Department of Neurology (M. Senel), University of Ulm; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (J.-P.S., V.H.), University Medical Center Hamburg-Eppendorf, Germany; 20. Aix-Marseille Univ (J.-P.S.), CNRS, CRMBM, UMR 7339; APHM (J.-P.S.), Hopital de la Timone, CEMEREM, Marseille, France; I.M. Sechenov First Moscow State Medical University (I.A.), Moscow, Russia; and Department of Neurology (O.A., M.R.), Medical Faculty, and Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich Heine University Düsseldorf, Germany.ORCID 0000-0002-8249-4408
Martin StangelFrom the Department of Neurology (M.W.H., L.M.S., M. Stangle, S.G., O.S.-K., C.T.), Hannover Medical School; NeuroCure Clinical Research Center (J.B.-S, N.S., F.P., A.D.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, and Max Delbrück Center for Molecular Medicine; Experimental and Clinical Research Center (J.B.-S., N.S., F.P., A.D.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin; Department of Neurology (F.P.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health; Institute of Clinical Neuroimmunology (H.P., T.K., J.H.), LMU Hospital, Ludwig-Maximilians Universität München, Munich; Institute of Neuropathology (H.P., M.S.W.), Department of Neurology, University Medical Center Göttingen; Molecular Neuroimmunology Group (S.J., B.W.), Department of Neurology, University of Heidelberg; Department of Neurology (A.B.), School of Medicine, Technical University Munich, Klinikum rechts der Isar; Department of Neurology (F.T.B.), University of Leipzig; Department of Neurology (M.P., L.K.), University of Münster; Department of Neurology (M.P.), Otto-von-Guericke University of Magdeburg; Marianne-Strauß-Klinik (I.K.), Behandlungszentrum Kempfenhausen für Multiple Sklerose Kranke, Berg; Department of Neurology (I.K., K.H., I.A.), St. Josef Hospital, Ruhr University Bochum; Department of Neurology (J.H.F.), Asklepios Expert Clinic Teupitz; Department of Neurology (R.P.), University of Essen; Department of Neurology (A.W.), Herford Hospital; Neuroimmunological Section (U.K.Z.), Department of Neurology, University of Rostock; Department of Neurology (M. Senel), University of Ulm; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (J.-P.S., V.H.), University Medical Center Hamburg-Eppendorf, Germany; 20. Aix-Marseille Univ (J.-P.S.), CNRS, CRMBM, UMR 7339; APHM (J.-P.S.), Hopital de la Timone, CEMEREM, Marseille, France; I.M. Sechenov First Moscow State Medical University (I.A.), Moscow, Russia; and Department of Neurology (O.A., M.R.), Medical Faculty, and Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich Heine University Düsseldorf, Germany.
Stefan GingeleFrom the Department of Neurology (M.W.H., L.M.S., M. Stangle, S.G., O.S.-K., C.T.), Hannover Medical School; NeuroCure Clinical Research Center (J.B.-S, N.S., F.P., A.D.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, and Max Delbrück Center for Molecular Medicine; Experimental and Clinical Research Center (J.B.-S., N.S., F.P., A.D.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin; Department of Neurology (F.P.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health; Institute of Clinical Neuroimmunology (H.P., T.K., J.H.), LMU Hospital, Ludwig-Maximilians Universität München, Munich; Institute of Neuropathology (H.P., M.S.W.), Department of Neurology, University Medical Center Göttingen; Molecular Neuroimmunology Group (S.J., B.W.), Department of Neurology, University of Heidelberg; Department of Neurology (A.B.), School of Medicine, Technical University Munich, Klinikum rechts der Isar; Department of Neurology (F.T.B.), University of Leipzig; Department of Neurology (M.P., L.K.), University of Münster; Department of Neurology (M.P.), Otto-von-Guericke University of Magdeburg; Marianne-Strauß-Klinik (I.K.), Behandlungszentrum Kempfenhausen für Multiple Sklerose Kranke, Berg; Department of Neurology (I.K., K.H., I.A.), St. Josef Hospital, Ruhr University Bochum; Department of Neurology (J.H.F.), Asklepios Expert Clinic Teupitz; Department of Neurology (R.P.), University of Essen; Department of Neurology (A.W.), Herford Hospital; Neuroimmunological Section (U.K.Z.), Department of Neurology, University of Rostock; Department of Neurology (M. Senel), University of Ulm; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (J.-P.S., V.H.), University Medical Center Hamburg-Eppendorf, Germany; 20. Aix-Marseille Univ (J.-P.S.), CNRS, CRMBM, UMR 7339; APHM (J.-P.S.), Hopital de la Timone, CEMEREM, Marseille, France; I.M. Sechenov First Moscow State Medical University (I.A.), Moscow, Russia; and Department of Neurology (O.A., M.R.), Medical Faculty, and Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich Heine University Düsseldorf, Germany.
Martin S WeberFrom the Department of Neurology (M.W.H., L.M.S., M. Stangle, S.G., O.S.-K., C.T.), Hannover Medical School; NeuroCure Clinical Research Center (J.B.-S, N.S., F.P., A.D.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, and Max Delbrück Center for Molecular Medicine; Experimental and Clinical Research Center (J.B.-S., N.S., F.P., A.D.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin; Department of Neurology (F.P.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health; Institute of Clinical Neuroimmunology (H.P., T.K., J.H.), LMU Hospital, Ludwig-Maximilians Universität München, Munich; Institute of Neuropathology (H.P., M.S.W.), Department of Neurology, University Medical Center Göttingen; Molecular Neuroimmunology Group (S.J., B.W.), Department of Neurology, University of Heidelberg; Department of Neurology (A.B.), School of Medicine, Technical University Munich, Klinikum rechts der Isar; Department of Neurology (F.T.B.), University of Leipzig; Department of Neurology (M.P., L.K.), University of Münster; Department of Neurology (M.P.), Otto-von-Guericke University of Magdeburg; Marianne-Strauß-Klinik (I.K.), Behandlungszentrum Kempfenhausen für Multiple Sklerose Kranke, Berg; Department of Neurology (I.K., K.H., I.A.), St. Josef Hospital, Ruhr University Bochum; Department of Neurology (J.H.F.), Asklepios Expert Clinic Teupitz; Department of Neurology (R.P.), University of Essen; Department of Neurology (A.W.), Herford Hospital; Neuroimmunological Section (U.K.Z.), Department of Neurology, University of Rostock; Department of Neurology (M. Senel), University of Ulm; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (J.-P.S., V.H.), University Medical Center Hamburg-Eppendorf, Germany; 20. Aix-Marseille Univ (J.-P.S.), CNRS, CRMBM, UMR 7339; APHM (J.-P.S.), Hopital de la Timone, CEMEREM, Marseille, France; I.M. Sechenov First Moscow State Medical University (I.A.), Moscow, Russia; and Department of Neurology (O.A., M.R.), Medical Faculty, and Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich Heine University Düsseldorf, Germany.
Juergen H FaissFrom the Department of Neurology (M.W.H., L.M.S., M. Stangle, S.G., O.S.-K., C.T.), Hannover Medical School; NeuroCure Clinical Research Center (J.B.-S, N.S., F.P., A.D.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, and Max Delbrück Center for Molecular Medicine; Experimental and Clinical Research Center (J.B.-S., N.S., F.P., A.D.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin; Department of Neurology (F.P.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health; Institute of Clinical Neuroimmunology (H.P., T.K., J.H.), LMU Hospital, Ludwig-Maximilians Universität München, Munich; Institute of Neuropathology (H.P., M.S.W.), Department of Neurology, University Medical Center Göttingen; Molecular Neuroimmunology Group (S.J., B.W.), Department of Neurology, University of Heidelberg; Department of Neurology (A.B.), School of Medicine, Technical University Munich, Klinikum rechts der Isar; Department of Neurology (F.T.B.), University of Leipzig; Department of Neurology (M.P., L.K.), University of Münster; Department of Neurology (M.P.), Otto-von-Guericke University of Magdeburg; Marianne-Strauß-Klinik (I.K.), Behandlungszentrum Kempfenhausen für Multiple Sklerose Kranke, Berg; Department of Neurology (I.K., K.H., I.A.), St. Josef Hospital, Ruhr University Bochum; Department of Neurology (J.H.F.), Asklepios Expert Clinic Teupitz; Department of Neurology (R.P.), University of Essen; Department of Neurology (A.W.), Herford Hospital; Neuroimmunological Section (U.K.Z.), Department of Neurology, University of Rostock; Department of Neurology (M. Senel), University of Ulm; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (J.-P.S., V.H.), University Medical Center Hamburg-Eppendorf, Germany; 20. Aix-Marseille Univ (J.-P.S.), CNRS, CRMBM, UMR 7339; APHM (J.-P.S.), Hopital de la Timone, CEMEREM, Marseille, France; I.M. Sechenov First Moscow State Medical University (I.A.), Moscow, Russia; and Department of Neurology (O.A., M.R.), Medical Faculty, and Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich Heine University Düsseldorf, Germany.
Refik PulFrom the Department of Neurology (M.W.H., L.M.S., M. Stangle, S.G., O.S.-K., C.T.), Hannover Medical School; NeuroCure Clinical Research Center (J.B.-S, N.S., F.P., A.D.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, and Max Delbrück Center for Molecular Medicine; Experimental and Clinical Research Center (J.B.-S., N.S., F.P., A.D.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin; Department of Neurology (F.P.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health; Institute of Clinical Neuroimmunology (H.P., T.K., J.H.), LMU Hospital, Ludwig-Maximilians Universität München, Munich; Institute of Neuropathology (H.P., M.S.W.), Department of Neurology, University Medical Center Göttingen; Molecular Neuroimmunology Group (S.J., B.W.), Department of Neurology, University of Heidelberg; Department of Neurology (A.B.), School of Medicine, Technical University Munich, Klinikum rechts der Isar; Department of Neurology (F.T.B.), University of Leipzig; Department of Neurology (M.P., L.K.), University of Münster; Department of Neurology (M.P.), Otto-von-Guericke University of Magdeburg; Marianne-Strauß-Klinik (I.K.), Behandlungszentrum Kempfenhausen für Multiple Sklerose Kranke, Berg; Department of Neurology (I.K., K.H., I.A.), St. Josef Hospital, Ruhr University Bochum; Department of Neurology (J.H.F.), Asklepios Expert Clinic Teupitz; Department of Neurology (R.P.), University of Essen; Department of Neurology (A.W.), Herford Hospital; Neuroimmunological Section (U.K.Z.), Department of Neurology, University of Rostock; Department of Neurology (M. Senel), University of Ulm; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (J.-P.S., V.H.), University Medical Center Hamburg-Eppendorf, Germany; 20. Aix-Marseille Univ (J.-P.S.), CNRS, CRMBM, UMR 7339; APHM (J.-P.S.), Hopital de la Timone, CEMEREM, Marseille, France; I.M. Sechenov First Moscow State Medical University (I.A.), Moscow, Russia; and Department of Neurology (O.A., M.R.), Medical Faculty, and Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich Heine University Düsseldorf, Germany.
Annette WalterFrom the Department of Neurology (M.W.H., L.M.S., M. Stangle, S.G., O.S.-K., C.T.), Hannover Medical School; NeuroCure Clinical Research Center (J.B.-S, N.S., F.P., A.D.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, and Max Delbrück Center for Molecular Medicine; Experimental and Clinical Research Center (J.B.-S., N.S., F.P., A.D.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin; Department of Neurology (F.P.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health; Institute of Clinical Neuroimmunology (H.P., T.K., J.H.), LMU Hospital, Ludwig-Maximilians Universität München, Munich; Institute of Neuropathology (H.P., M.S.W.), Department of Neurology, University Medical Center Göttingen; Molecular Neuroimmunology Group (S.J., B.W.), Department of Neurology, University of Heidelberg; Department of Neurology (A.B.), School of Medicine, Technical University Munich, Klinikum rechts der Isar; Department of Neurology (F.T.B.), University of Leipzig; Department of Neurology (M.P., L.K.), University of Münster; Department of Neurology (M.P.), Otto-von-Guericke University of Magdeburg; Marianne-Strauß-Klinik (I.K.), Behandlungszentrum Kempfenhausen für Multiple Sklerose Kranke, Berg; Department of Neurology (I.K., K.H., I.A.), St. Josef Hospital, Ruhr University Bochum; Department of Neurology (J.H.F.), Asklepios Expert Clinic Teupitz; Department of Neurology (R.P.), University of Essen; Department of Neurology (A.W.), Herford Hospital; Neuroimmunological Section (U.K.Z.), Department of Neurology, University of Rostock; Department of Neurology (M. Senel), University of Ulm; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (J.-P.S., V.H.), University Medical Center Hamburg-Eppendorf, Germany; 20. Aix-Marseille Univ (J.-P.S.), CNRS, CRMBM, UMR 7339; APHM (J.-P.S.), Hopital de la Timone, CEMEREM, Marseille, France; I.M. Sechenov First Moscow State Medical University (I.A.), Moscow, Russia; and Department of Neurology (O.A., M.R.), Medical Faculty, and Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich Heine University Düsseldorf, Germany.
Uwe K ZettlFrom the Department of Neurology (M.W.H., L.M.S., M. Stangle, S.G., O.S.-K., C.T.), Hannover Medical School; NeuroCure Clinical Research Center (J.B.-S, N.S., F.P., A.D.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, and Max Delbrück Center for Molecular Medicine; Experimental and Clinical Research Center (J.B.-S., N.S., F.P., A.D.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin; Department of Neurology (F.P.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health; Institute of Clinical Neuroimmunology (H.P., T.K., J.H.), LMU Hospital, Ludwig-Maximilians Universität München, Munich; Institute of Neuropathology (H.P., M.S.W.), Department of Neurology, University Medical Center Göttingen; Molecular Neuroimmunology Group (S.J., B.W.), Department of Neurology, University of Heidelberg; Department of Neurology (A.B.), School of Medicine, Technical University Munich, Klinikum rechts der Isar; Department of Neurology (F.T.B.), University of Leipzig; Department of Neurology (M.P., L.K.), University of Münster; Department of Neurology (M.P.), Otto-von-Guericke University of Magdeburg; Marianne-Strauß-Klinik (I.K.), Behandlungszentrum Kempfenhausen für Multiple Sklerose Kranke, Berg; Department of Neurology (I.K., K.H., I.A.), St. Josef Hospital, Ruhr University Bochum; Department of Neurology (J.H.F.), Asklepios Expert Clinic Teupitz; Department of Neurology (R.P.), University of Essen; Department of Neurology (A.W.), Herford Hospital; Neuroimmunological Section (U.K.Z.), Department of Neurology, University of Rostock; Department of Neurology (M. Senel), University of Ulm; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (J.-P.S., V.H.), University Medical Center Hamburg-Eppendorf, Germany; 20. Aix-Marseille Univ (J.-P.S.), CNRS, CRMBM, UMR 7339; APHM (J.-P.S.), Hopital de la Timone, CEMEREM, Marseille, France; I.M. Sechenov First Moscow State Medical University (I.A.), Moscow, Russia; and Department of Neurology (O.A., M.R.), Medical Faculty, and Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich Heine University Düsseldorf, Germany.
Makbule SenelFrom the Department of Neurology (M.W.H., L.M.S., M. Stangle, S.G., O.S.-K., C.T.), Hannover Medical School; NeuroCure Clinical Research Center (J.B.-S, N.S., F.P., A.D.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, and Max Delbrück Center for Molecular Medicine; Experimental and Clinical Research Center (J.B.-S., N.S., F.P., A.D.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin; Department of Neurology (F.P.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health; Institute of Clinical Neuroimmunology (H.P., T.K., J.H.), LMU Hospital, Ludwig-Maximilians Universität München, Munich; Institute of Neuropathology (H.P., M.S.W.), Department of Neurology, University Medical Center Göttingen; Molecular Neuroimmunology Group (S.J., B.W.), Department of Neurology, University of Heidelberg; Department of Neurology (A.B.), School of Medicine, Technical University Munich, Klinikum rechts der Isar; Department of Neurology (F.T.B.), University of Leipzig; Department of Neurology (M.P., L.K.), University of Münster; Department of Neurology (M.P.), Otto-von-Guericke University of Magdeburg; Marianne-Strauß-Klinik (I.K.), Behandlungszentrum Kempfenhausen für Multiple Sklerose Kranke, Berg; Department of Neurology (I.K., K.H., I.A.), St. Josef Hospital, Ruhr University Bochum; Department of Neurology (J.H.F.), Asklepios Expert Clinic Teupitz; Department of Neurology (R.P.), University of Essen; Department of Neurology (A.W.), Herford Hospital; Neuroimmunological Section (U.K.Z.), Department of Neurology, University of Rostock; Department of Neurology (M. Senel), University of Ulm; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (J.-P.S., V.H.), University Medical Center Hamburg-Eppendorf, Germany; 20. Aix-Marseille Univ (J.-P.S.), CNRS, CRMBM, UMR 7339; APHM (J.-P.S.), Hopital de la Timone, CEMEREM, Marseille, France; I.M. Sechenov First Moscow State Medical University (I.A.), Moscow, Russia; and Department of Neurology (O.A., M.R.), Medical Faculty, and Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich Heine University Düsseldorf, Germany.
Jan-Patrick StellmannFrom the Department of Neurology (M.W.H., L.M.S., M. Stangle, S.G., O.S.-K., C.T.), Hannover Medical School; NeuroCure Clinical Research Center (J.B.-S, N.S., F.P., A.D.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, and Max Delbrück Center for Molecular Medicine; Experimental and Clinical Research Center (J.B.-S., N.S., F.P., A.D.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin; Department of Neurology (F.P.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health; Institute of Clinical Neuroimmunology (H.P., T.K., J.H.), LMU Hospital, Ludwig-Maximilians Universität München, Munich; Institute of Neuropathology (H.P., M.S.W.), Department of Neurology, University Medical Center Göttingen; Molecular Neuroimmunology Group (S.J., B.W.), Department of Neurology, University of Heidelberg; Department of Neurology (A.B.), School of Medicine, Technical University Munich, Klinikum rechts der Isar; Department of Neurology (F.T.B.), University of Leipzig; Department of Neurology (M.P., L.K.), University of Münster; Department of Neurology (M.P.), Otto-von-Guericke University of Magdeburg; Marianne-Strauß-Klinik (I.K.), Behandlungszentrum Kempfenhausen für Multiple Sklerose Kranke, Berg; Department of Neurology (I.K., K.H., I.A.), St. Josef Hospital, Ruhr University Bochum; Department of Neurology (J.H.F.), Asklepios Expert Clinic Teupitz; Department of Neurology (R.P.), University of Essen; Department of Neurology (A.W.), Herford Hospital; Neuroimmunological Section (U.K.Z.), Department of Neurology, University of Rostock; Department of Neurology (M. Senel), University of Ulm; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (J.-P.S., V.H.), University Medical Center Hamburg-Eppendorf, Germany; 20. Aix-Marseille Univ (J.-P.S.), CNRS, CRMBM, UMR 7339; APHM (J.-P.S.), Hopital de la Timone, CEMEREM, Marseille, France; I.M. Sechenov First Moscow State Medical University (I.A.), Moscow, Russia; and Department of Neurology (O.A., M.R.), Medical Faculty, and Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich Heine University Düsseldorf, Germany.ORCID 0000-0003-2565-2833
Vivien HäußlerFrom the Department of Neurology (M.W.H., L.M.S., M. Stangle, S.G., O.S.-K., C.T.), Hannover Medical School; NeuroCure Clinical Research Center (J.B.-S, N.S., F.P., A.D.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, and Max Delbrück Center for Molecular Medicine; Experimental and Clinical Research Center (J.B.-S., N.S., F.P., A.D.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin; Department of Neurology (F.P.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health; Institute of Clinical Neuroimmunology (H.P., T.K., J.H.), LMU Hospital, Ludwig-Maximilians Universität München, Munich; Institute of Neuropathology (H.P., M.S.W.), Department of Neurology, University Medical Center Göttingen; Molecular Neuroimmunology Group (S.J., B.W.), Department of Neurology, University of Heidelberg; Department of Neurology (A.B.), School of Medicine, Technical University Munich, Klinikum rechts der Isar; Department of Neurology (F.T.B.), University of Leipzig; Department of Neurology (M.P., L.K.), University of Münster; Department of Neurology (M.P.), Otto-von-Guericke University of Magdeburg; Marianne-Strauß-Klinik (I.K.), Behandlungszentrum Kempfenhausen für Multiple Sklerose Kranke, Berg; Department of Neurology (I.K., K.H., I.A.), St. Josef Hospital, Ruhr University Bochum; Department of Neurology (J.H.F.), Asklepios Expert Clinic Teupitz; Department of Neurology (R.P.), University of Essen; Department of Neurology (A.W.), Herford Hospital; Neuroimmunological Section (U.K.Z.), Department of Neurology, University of Rostock; Department of Neurology (M. Senel), University of Ulm; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (J.-P.S., V.H.), University Medical Center Hamburg-Eppendorf, Germany; 20. Aix-Marseille Univ (J.-P.S.), CNRS, CRMBM, UMR 7339; APHM (J.-P.S.), Hopital de la Timone, CEMEREM, Marseille, France; I.M. Sechenov First Moscow State Medical University (I.A.), Moscow, Russia; and Department of Neurology (O.A., M.R.), Medical Faculty, and Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich Heine University Düsseldorf, Germany.ORCID 0000-0002-7787-7391
Kerstin HellwigFrom the Department of Neurology (M.W.H., L.M.S., M. Stangle, S.G., O.S.-K., C.T.), Hannover Medical School; NeuroCure Clinical Research Center (J.B.-S, N.S., F.P., A.D.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, and Max Delbrück Center for Molecular Medicine; Experimental and Clinical Research Center (J.B.-S., N.S., F.P., A.D.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin; Department of Neurology (F.P.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health; Institute of Clinical Neuroimmunology (H.P., T.K., J.H.), LMU Hospital, Ludwig-Maximilians Universität München, Munich; Institute of Neuropathology (H.P., M.S.W.), Department of Neurology, University Medical Center Göttingen; Molecular Neuroimmunology Group (S.J., B.W.), Department of Neurology, University of Heidelberg; Department of Neurology (A.B.), School of Medicine, Technical University Munich, Klinikum rechts der Isar; Department of Neurology (F.T.B.), University of Leipzig; Department of Neurology (M.P., L.K.), University of Münster; Department of Neurology (M.P.), Otto-von-Guericke University of Magdeburg; Marianne-Strauß-Klinik (I.K.), Behandlungszentrum Kempfenhausen für Multiple Sklerose Kranke, Berg; Department of Neurology (I.K., K.H., I.A.), St. Josef Hospital, Ruhr University Bochum; Department of Neurology (J.H.F.), Asklepios Expert Clinic Teupitz; Department of Neurology (R.P.), University of Essen; Department of Neurology (A.W.), Herford Hospital; Neuroimmunological Section (U.K.Z.), Department of Neurology, University of Rostock; Department of Neurology (M. Senel), University of Ulm; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (J.-P.S., V.H.), University Medical Center Hamburg-Eppendorf, Germany; 20. Aix-Marseille Univ (J.-P.S.), CNRS, CRMBM, UMR 7339; APHM (J.-P.S.), Hopital de la Timone, CEMEREM, Marseille, France; I.M. Sechenov First Moscow State Medical University (I.A.), Moscow, Russia; and Department of Neurology (O.A., M.R.), Medical Faculty, and Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich Heine University Düsseldorf, Germany.ORCID 0000-0003-4467-9011
Ilya AyzenbergFrom the Department of Neurology (M.W.H., L.M.S., M. Stangle, S.G., O.S.-K., C.T.), Hannover Medical School; NeuroCure Clinical Research Center (J.B.-S, N.S., F.P., A.D.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, and Max Delbrück Center for Molecular Medicine; Experimental and Clinical Research Center (J.B.-S., N.S., F.P., A.D.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin; Department of Neurology (F.P.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health; Institute of Clinical Neuroimmunology (H.P., T.K., J.H.), LMU Hospital, Ludwig-Maximilians Universität München, Munich; Institute of Neuropathology (H.P., M.S.W.), Department of Neurology, University Medical Center Göttingen; Molecular Neuroimmunology Group (S.J., B.W.), Department of Neurology, University of Heidelberg; Department of Neurology (A.B.), School of Medicine, Technical University Munich, Klinikum rechts der Isar; Department of Neurology (F.T.B.), University of Leipzig; Department of Neurology (M.P., L.K.), University of Münster; Department of Neurology (M.P.), Otto-von-Guericke University of Magdeburg; Marianne-Strauß-Klinik (I.K.), Behandlungszentrum Kempfenhausen für Multiple Sklerose Kranke, Berg; Department of Neurology (I.K., K.H., I.A.), St. Josef Hospital, Ruhr University Bochum; Department of Neurology (J.H.F.), Asklepios Expert Clinic Teupitz; Department of Neurology (R.P.), University of Essen; Department of Neurology (A.W.), Herford Hospital; Neuroimmunological Section (U.K.Z.), Department of Neurology, University of Rostock; Department of Neurology (M. Senel), University of Ulm; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (J.-P.S., V.H.), University Medical Center Hamburg-Eppendorf, Germany; 20. Aix-Marseille Univ (J.-P.S.), CNRS, CRMBM, UMR 7339; APHM (J.-P.S.), Hopital de la Timone, CEMEREM, Marseille, France; I.M. Sechenov First Moscow State Medical University (I.A.), Moscow, Russia; and Department of Neurology (O.A., M.R.), Medical Faculty, and Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich Heine University Düsseldorf, Germany.
Orhan AktasFrom the Department of Neurology (M.W.H., L.M.S., M. Stangle, S.G., O.S.-K., C.T.), Hannover Medical School; NeuroCure Clinical Research Center (J.B.-S, N.S., F.P., A.D.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, and Max Delbrück Center for Molecular Medicine; Experimental and Clinical Research Center (J.B.-S., N.S., F.P., A.D.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin; Department of Neurology (F.P.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health; Institute of Clinical Neuroimmunology (H.P., T.K., J.H.), LMU Hospital, Ludwig-Maximilians Universität München, Munich; Institute of Neuropathology (H.P., M.S.W.), Department of Neurology, University Medical Center Göttingen; Molecular Neuroimmunology Group (S.J., B.W.), Department of Neurology, University of Heidelberg; Department of Neurology (A.B.), School of Medicine, Technical University Munich, Klinikum rechts der Isar; Department of Neurology (F.T.B.), University of Leipzig; Department of Neurology (M.P., L.K.), University of Münster; Department of Neurology (M.P.), Otto-von-Guericke University of Magdeburg; Marianne-Strauß-Klinik (I.K.), Behandlungszentrum Kempfenhausen für Multiple Sklerose Kranke, Berg; Department of Neurology (I.K., K.H., I.A.), St. Josef Hospital, Ruhr University Bochum; Department of Neurology (J.H.F.), Asklepios Expert Clinic Teupitz; Department of Neurology (R.P.), University of Essen; Department of Neurology (A.W.), Herford Hospital; Neuroimmunological Section (U.K.Z.), Department of Neurology, University of Rostock; Department of Neurology (M. Senel), University of Ulm; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (J.-P.S., V.H.), University Medical Center Hamburg-Eppendorf, Germany; 20. Aix-Marseille Univ (J.-P.S.), CNRS, CRMBM, UMR 7339; APHM (J.-P.S.), Hopital de la Timone, CEMEREM, Marseille, France; I.M. Sechenov First Moscow State Medical University (I.A.), Moscow, Russia; and Department of Neurology (O.A., M.R.), Medical Faculty, and Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich Heine University Düsseldorf, Germany.ORCID 0000-0002-2020-9210
Marius RingelsteinFrom the Department of Neurology (M.W.H., L.M.S., M. Stangle, S.G., O.S.-K., C.T.), Hannover Medical School; NeuroCure Clinical Research Center (J.B.-S, N.S., F.P., A.D.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, and Max Delbrück Center for Molecular Medicine; Experimental and Clinical Research Center (J.B.-S., N.S., F.P., A.D.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin; Department of Neurology (F.P.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health; Institute of Clinical Neuroimmunology (H.P., T.K., J.H.), LMU Hospital, Ludwig-Maximilians Universität München, Munich; Institute of Neuropathology (H.P., M.S.W.), Department of Neurology, University Medical Center Göttingen; Molecular Neuroimmunology Group (S.J., B.W.), Department of Neurology, University of Heidelberg; Department of Neurology (A.B.), School of Medicine, Technical University Munich, Klinikum rechts der Isar; Department of Neurology (F.T.B.), University of Leipzig; Department of Neurology (M.P., L.K.), University of Münster; Department of Neurology (M.P.), Otto-von-Guericke University of Magdeburg; Marianne-Strauß-Klinik (I.K.), Behandlungszentrum Kempfenhausen für Multiple Sklerose Kranke, Berg; Department of Neurology (I.K., K.H., I.A.), St. Josef Hospital, Ruhr University Bochum; Department of Neurology (J.H.F.), Asklepios Expert Clinic Teupitz; Department of Neurology (R.P.), University of Essen; Department of Neurology (A.W.), Herford Hospital; Neuroimmunological Section (U.K.Z.), Department of Neurology, University of Rostock; Department of Neurology (M. Senel), University of Ulm; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (J.-P.S., V.H.), University Medical Center Hamburg-Eppendorf, Germany; 20. Aix-Marseille Univ (J.-P.S.), CNRS, CRMBM, UMR 7339; APHM (J.-P.S.), Hopital de la Timone, CEMEREM, Marseille, France; I.M. Sechenov First Moscow State Medical University (I.A.), Moscow, Russia; and Department of Neurology (O.A., M.R.), Medical Faculty, and Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich Heine University Düsseldorf, Germany.
Olivia Schreiber-KatzFrom the Department of Neurology (M.W.H., L.M.S., M. Stangle, S.G., O.S.-K., C.T.), Hannover Medical School; NeuroCure Clinical Research Center (J.B.-S, N.S., F.P., A.D.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, and Max Delbrück Center for Molecular Medicine; Experimental and Clinical Research Center (J.B.-S., N.S., F.P., A.D.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin; Department of Neurology (F.P.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health; Institute of Clinical Neuroimmunology (H.P., T.K., J.H.), LMU Hospital, Ludwig-Maximilians Universität München, Munich; Institute of Neuropathology (H.P., M.S.W.), Department of Neurology, University Medical Center Göttingen; Molecular Neuroimmunology Group (S.J., B.W.), Department of Neurology, University of Heidelberg; Department of Neurology (A.B.), School of Medicine, Technical University Munich, Klinikum rechts der Isar; Department of Neurology (F.T.B.), University of Leipzig; Department of Neurology (M.P., L.K.), University of Münster; Department of Neurology (M.P.), Otto-von-Guericke University of Magdeburg; Marianne-Strauß-Klinik (I.K.), Behandlungszentrum Kempfenhausen für Multiple Sklerose Kranke, Berg; Department of Neurology (I.K., K.H., I.A.), St. Josef Hospital, Ruhr University Bochum; Department of Neurology (J.H.F.), Asklepios Expert Clinic Teupitz; Department of Neurology (R.P.), University of Essen; Department of Neurology (A.W.), Herford Hospital; Neuroimmunological Section (U.K.Z.), Department of Neurology, University of Rostock; Department of Neurology (M. Senel), University of Ulm; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (J.-P.S., V.H.), University Medical Center Hamburg-Eppendorf, Germany; 20. Aix-Marseille Univ (J.-P.S.), CNRS, CRMBM, UMR 7339; APHM (J.-P.S.), Hopital de la Timone, CEMEREM, Marseille, France; I.M. Sechenov First Moscow State Medical University (I.A.), Moscow, Russia; and Department of Neurology (O.A., M.R.), Medical Faculty, and Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich Heine University Düsseldorf, Germany.ORCID 0000-0001-5621-4487
Corinna TrebstFrom the Department of Neurology (M.W.H., L.M.S., M. Stangle, S.G., O.S.-K., C.T.), Hannover Medical School; NeuroCure Clinical Research Center (J.B.-S, N.S., F.P., A.D.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, and Max Delbrück Center for Molecular Medicine; Experimental and Clinical Research Center (J.B.-S., N.S., F.P., A.D.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin; Department of Neurology (F.P.), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health; Institute of Clinical Neuroimmunology (H.P., T.K., J.H.), LMU Hospital, Ludwig-Maximilians Universität München, Munich; Institute of Neuropathology (H.P., M.S.W.), Department of Neurology, University Medical Center Göttingen; Molecular Neuroimmunology Group (S.J., B.W.), Department of Neurology, University of Heidelberg; Department of Neurology (A.B.), School of Medicine, Technical University Munich, Klinikum rechts der Isar; Department of Neurology (F.T.B.), University of Leipzig; Department of Neurology (M.P., L.K.), University of Münster; Department of Neurology (M.P.), Otto-von-Guericke University of Magdeburg; Marianne-Strauß-Klinik (I.K.), Behandlungszentrum Kempfenhausen für Multiple Sklerose Kranke, Berg; Department of Neurology (I.K., K.H., I.A.), St. Josef Hospital, Ruhr University Bochum; Department of Neurology (J.H.F.), Asklepios Expert Clinic Teupitz; Department of Neurology (R.P.), University of Essen; Department of Neurology (A.W.), Herford Hospital; Neuroimmunological Section (U.K.Z.), Department of Neurology, University of Rostock; Department of Neurology (M. Senel), University of Ulm; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (J.-P.S., V.H.), University Medical Center Hamburg-Eppendorf, Germany; 20. Aix-Marseille Univ (J.-P.S.), CNRS, CRMBM, UMR 7339; APHM (J.-P.S.), Hopital de la Timone, CEMEREM, Marseille, France; I.M. Sechenov First Moscow State Medical University (I.A.), Moscow, Russia; and Department of Neurology (O.A., M.R.), Medical Faculty, and Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich Heine University Düsseldorf, Germany. trebst.corinna@mh-hannover.de.
Neuromyelitis Optica Study Group (NEMOS)

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesTo evaluate costs and health-related quality of life (HRQoL) of neuromyelitis optica spectrum disorders (NMOSD) and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD).

methodsIn this multicenter cross-sectional study, data on consumption of medical and nonmedical resources and work ability were assessed via patient questionnaires. Costs were analyzed in Euros for 2018 from the societal perspective. HRQoL was captured by the EuroQoL Group 5 Dimension 5 Level Scale (EQ-5D-5L) questionnaire. Clinical data were retrieved from the Neuromyelitis Optica Study Group (NEMOS) database.

resultsTwo hundred twelve patients (80% women, median age 50 [19-83] years, median disease duration 7 [0-43] years, median Expanded Disability Status Scale [EDSS] score 3.5 [0-8.5], 66% aquaporin-4 immunoglobulin G [IgG] positive, 22% MOG IgG positive, 12% double seronegative) were analyzed. The mean total annual per capita cost of illness accounted for €59,574 (95% CI 51,225-68,293 or US dollars [USD] 70,297, 95% CI 60,445-80,586), and the mean index value of the EQ-5D-5L was 0.693 (95% CI 0.65-0.73). The most important cost drivers were informal care costs (28% of total costs), indirect costs (23%), and drugs (16%), especially immunotherapeutics. Costs showed a positive correlation with disease severity (ρ = 0.56, 95% CI 0.45-0.65); in the EDSS score 6.5 to 8.5 subgroup, the mean annual costs were €129,687 (95% CI 101,946-160,336 or USD 153,031, 95% CI 120,296-189,196). The HRQoL revealed a negative correlation to disease severity (ρ = -0.69, 95% CI -0.76 to -0.61); in the EDSS score 6.5 to 8.5 subgroup, the EQ-5D-5L mean index value was 0.195 (95% CI 0.13-0.28). Neither antibody status nor disease duration influenced the total annual costs or HRQoL. DISCUSSION: These German data from the era without approved preventive immunotherapies show enormous effects of the diseases on costs and quality of life. An early and cost-effective therapy should be provided to prevent long-term disability and to preserve quality of life.

Indexed as

Neuromyelitis OpticaAdultAgedAged, 80 and overAquaporin 4AutoantibodiesCross-Sectional StudiesFemaleHumansMaleMiddle AgedMyelin-Oligodendrocyte GlycoproteinQuality of LifeYoung AdultAquaporin 4AutoantibodiesMyelin-Oligodendrocyte Glycoprotein

Identifiers

PMID35082170
PMCPMC8935443

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