Evidence map›Paper›PMID 35082154›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Immunomagnetic microscopy of tumor tissues using quantum sensors in diamond.

Sanyou Chen, Wanhe Li, Xiaohu Zheng, Pei Yu, Pengfei Wang, Ziting Sun, Yao Xu, Defeng Jiao, Xiangyu Ye, Mingcheng Cai and 9 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 53 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Widefield Diamond Quantum Sensing with Neuromorphic Vision Sensors.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 1 institution in 1 country.

Sanyou ChenHefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei 230026, China.
Wanhe LiHefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei 230026, China.
Xiaohu ZhengHefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei 230026, China.
Pei YuHefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei 230026, China.
Pengfei WangHefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei 230026, China.ORCID 0000-0001-5112-0502
Ziting SunHefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei 230026, China.ORCID 0000-0001-8475-1378
Yao XuHefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei 230026, China.
Defeng JiaoHefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei 230026, China.
Xiangyu YeHefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei 230026, China.ORCID 0000-0002-8309-2101
Mingcheng CaiHefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei 230026, China.
Mengze ShenHefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei 230026, China.
Mengqi WangHefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei 230026, China.
Qi ZhangHefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei 230026, China.ORCID 0000-0001-8889-2039
Fei KongHefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei 230026, China.
Ya WangHefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei 230026, China.ORCID 0000-0001-6232-7234
Jie HeDepartment of Pathology, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China.ORCID 0000-0002-1739-6625
Haiming WeiHefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei 230026, China.
Fazhan ShiHefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei 230026, China; fzshi@ustc.edu.cn djf@ustc.edu.cn.
Jiangfeng DuHefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei 230026, China; fzshi@ustc.edu.cn djf@ustc.edu.cn.
University of Science and Technology of China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Histological imaging is essential for the biomedical research and clinical diagnosis of human cancer. Although optical microscopy provides a standard method, it is a persistent goal to develop new imaging methods for more precise histological examination. Here, we use nitrogen-vacancy centers in diamond as quantum sensors and demonstrate micrometer-resolution immunomagnetic microscopy (IMM) for human tumor tissues. We immunomagnetically labeled cancer biomarkers in tumor tissues with magnetic nanoparticles and imaged them in a 400-nm resolution diamond-based magnetic microscope. There is barely magnetic background in tissues, and the IMM can resist the impact of a light background. The distribution of biomarkers in the high-contrast magnetic images was reconstructed as that of the magnetic moment of magnetic nanoparticles by employing deep-learning algorithms. In the reconstructed magnetic images, the expression intensity of the biomarkers was quantified with the absolute magnetic signal. The IMM has excellent signal stability, and the magnetic signal in our samples had not changed after more than 1.5 y under ambient conditions. Furthermore, we realized multimodal imaging of tumor tissues by combining IMM with hematoxylin-eosin staining, immunohistochemistry, or immunofluorescence microscopy in the same tissue section. Overall, our study provides a different histological method for both molecular mechanism research and accurate diagnosis of human cancer.

Indexed as

DiamondHumansImage Processing, Computer-AssistedMagneticsMicroscopy, FluorescenceNanoparticlesNeoplasmsNitrogenQuantum DotsDiamondNitrogenabsolute magnetic quantificationhistological magnetometrymicrometer-resolution magnetic imagingnitrogen-vacancy centertumor tissue

Identifiers

PMID35082154
PMCPMC8812536
OpenAlexW4210409343

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.