Trial reportOpen heart2022
Uncovering the treatable burden of severe aortic stenosis in the UK.
Trial report in Open heart, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Comparison of different timings of percutaneous coronary intervention in patients with transcatheter aortic valve implantation: a network meta-analysis.Frontiers in cardiovascular medicine · 2025Pooled it
- Article
- Same-Day Discharge After Transcatheter Aortic Valve Implantation: Who, When, and How?Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2026Review
- Cost-Utility Analysis of TAVI Versus Surgery in Low-Risk Patients with Severe Aortic Stenosis in the UK.Applied health economics and health policy · 2026Article
- Safety and effectiveness of remote monitoring and prioritization of patients awaiting transcatheter aortic valve implantation: a propensity-matched prospective observational cohort study.European heart journal. Digital health · 2026Article
- Diagnosing Severe Low-Gradient vs Moderate Aortic Stenosis with Artificial Intelligence Based on Echocardiography Images.Journal of imaging informatics in medicine · 2026Article
- Exploratory Cost-Effectiveness of a Novel Bioprosthetic Valve for Surgical Aortic Valve Replacement in Spain.PharmacoEconomics - open · 2025Article
- Review
- Racial and ethnic disparities in aortic stenosis within a universal healthcare system characterized by natural language processing for targeted intervention.European heart journal. Digital health · 2025Article
- Sutureless aortic valve and post-operative atrial fibrillation: Five-year outcomes from a propensity matched cohort study.World journal of cardiology · 2025Article
- Cardiac Rehabilitation in TAVI Patients: Safety and Benefits: A Narrative Review.Medicina (Kaunas, Lithuania) · 2025Review
- Global distribution of prognostically significant pulmonary pressure indicative of pulmonary hypertension.Journal of global health · 2025Article
- Surgical and transcatheter aortic valve interventions for aortic stenosis in England: sociodemographic variations in treatment trends and outcome over 20 years.Heart (British Cardiac Society) · 2025Article
- Transcatheter aortic valve implantation complexity score.Open heart · 2025Article
- Machine learning-enabled screening for aortic stenosis with handheld ultrasound.European heart journal. Imaging methods and practice · 2025Article
- Postcode health inequalities in aortic valve surgery in North East England: retrospective study of disparities in presentation and hospital outcomes.BMJ public health · 2025Article
- Prognostic implications and alterations in left atrial deformation following transcatheter aortic valve implantation.European heart journal. Cardiovascular Imaging · 2024Article
- Efficient deep learning-based automated diagnosis from echocardiography with contrastive self-supervised learning.Communications medicine · 2024Article
- Heart valve service provision in the United Kingdom and the effect of the COVID 19 pandemic; improved but must do better. A British Heart Valve Society national survey.Echo research and practice · 2024Article
- Geographical Inequality in Access to Aortic Valve Intervention in England: A Report from the UK Transcatheter Aortic Valve Implantation Registry and National Adult Cardiac Surgery Audit.Interventional cardiology (London, England) · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 10 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo estimate the population prevalence and treatable burden of severe aortic stenosis (AS) in the UK.
methodsWe adapted a contemporary model of the population profile of symptomatic and asymptomatic severe AS in Europe and North America to estimate the number of people aged ≥55 years in the UK who might benefit from surgical aortic valve replacement (SAVR) or transcatheter aortic valve implantation (TAVI).
resultsWith a point prevalence of 1.48%, we estimate that 291 448 men and women aged ≥55 years in the UK had severe AS in 2019. Of these, 68.3% (199 059, 95% CI 1 77 201 to 221 355 people) would have been symptomatic and, therefore, more readily treated according to their surgical risk profile; the remaining 31.7% of cases (92 389, 95% CI 70 093 to 144 247) being asymptomatic. Based on historical patterns of intervention, 58.4% (116 251, 95% CI 106 895 to 1 25 606) of the 199 059 symptomatic cases would qualify for SAVR, with 7208 (95% CI 7091 to 7234) being assessed as being in a high, preoperative surgical risk category. Among the remaining 41.6% (82 809, 95% CI 73 453 to 92 164) of cases potentially unsuitable for SAVR, an estimated 61.7% (51 093, 95% CI 34 780 to 67 655) might be suitable for TAVI. We estimate that 172 859 out of 291 448 prevalent cases of severe AS (59.3%) will subsequently die within 5 years without proactive management.
conclusionsThese data suggest a high burden of severe AS in the UK requiring surgical or transcatheter intervention that challenges the ongoing capacity of the National Health Service to meet the needs of those affected.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.