ArticleBMC medicine2022
Malaria hospitalisation in East Africa: age, phenotype and transmission intensity.
Article in BMC medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- The burden of malaria in East Africa: prevalence, risk factors, and control strategies.Malaria journal · 2025Pooled it
- Assessing the potential impact of the RTS,S/ASO1 vaccine on malaria burden in Benin: a mathematical modelling approach.Malaria journal · 2026Article
- Heme and immunity: The heme oxygenase dichotomy.Journal of inorganic biochemistry · 2025Review
- Retrospective analysis of malaria prevalence over ten years (2015-2024) at Bichena Primary Hospital, Amhara Region, Ethiopia.PloS one · 2025Article
- Paediatric anaemia in rural Kenya and the role of travel time to emergency care services.Frontiers in epidemiology · 2025Article
- Prevalence and factors associated with cerebral malaria among children aged 6 to 59 months with severe malaria in Western Uganda: a hospital-based cross-sectional study.BMC pediatrics · 2024Article
- The influence of malaria control interventions and climate variability on changes in the geographical distribution of parasite prevalence in Kenya between 2015 and 2020.International journal of health geographics · 2024Article
- Severe outcomes of malaria in children under time-varying exposure.Nature communications · 2024Article
- sTREM-1: A Biomarker of Mortality in Severe Malaria Impacted by Acute Kidney Injury.The Journal of infectious diseases · 2024Article
- Prediction of malaria positivity using patients' demographic and environmental features and clinical symptoms to complement parasitological confirmation before treatment.Tropical diseases, travel medicine and vaccines · 2023Article
- Review
- Malaria vaccine coverage estimation using age-eligible populations and service user denominators in Kenya.Malaria journal · 2023Article
- Geographic accessibility and hospital competition for emergency blood transfusion services in Bungoma, Western Kenya.International journal of health geographics · 2023Article
- Assessment of malaria prevention knowledge, attitude, and practice and associated factors among households living in rural malaria-endemic areas in the Afar Pastoral Region of Ethiopia.Frontiers in public health · 2023Article
- Severe malaria.Malaria journal · 2022Review
- Resurgent and delayed malaria.Malaria journal · 2022Review
- Malaria hospitalisation in East Africa: age, phenotype and transmission intensity.BMC medicine · 2022Article
Corrections and comments
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Authors and funding
30 authors at 7 institutions in 4 countries.
Funding
Abstract
backgroundUnderstanding the age patterns of disease is necessary to target interventions to maximise cost-effective impact. New malaria chemoprevention and vaccine initiatives target young children attending routine immunisation services. Here we explore the relationships between age and severity of malaria hospitalisation versus malaria transmission intensity.
methodsClinical data from 21 surveillance hospitals in East Africa were reviewed. Malaria admissions aged 1 month to 14 years from discrete administrative areas since 2006 were identified. Each site-time period was matched to a model estimated community-based age-corrected parasite prevalence to provide predictions of prevalence in childhood (PfPR
results52,684 malaria admissions aged 1 month to 14 years were described at 21 hospitals from 49 site-time locations where PfPR
conclusionsTargeting chemoprevention or vaccination programmes to areas where community-based parasite prevalence is ≥10% is likely to match the age ranges covered by interventions (e.g. intermittent presumptive treatment in infancy to children aged 2-23 months and current vaccine age eligibility and duration of efficacy) and the age ranges of highest disease burden.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.