ArticleBMC nephrology2022
Patient activation and its association with symptom burden and quality of life across the spectrum of chronic kidney disease stages in England.
Article in BMC nephrology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Feasibility, acceptability and preliminary impact on diet quality of the Healthy Weight for Life™ + medical nutrition therapy; a randomised controlled pilot study.The international journal of behavioral nutrition and physical activity · 2026Trial
- The minimal clinically important difference for the patient activation measure in a culturally and linguistically diverse cohort with chronic conditions.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026Trial
- Biopsychosocial Correlates of Somatic Symptom Burden in CKD: Results of the Hamburg City Health Study.Kidney360 · 2026Article
- A new self-management engagement scale for haemodialysis patients (PRIESM CKD-HD): development and validation.Clinical kidney journal · 2026Article
- A latent profile analysis of hierarchical management of supportive care needs in patients undergoing maintenance hemodialysis.Scientific reports · 2026Article
- Feasibility and Acceptability of a Co-Designed Self-Management Programme for People Living With Kidney Failure.Journal of renal care · 2026Article
- "Understanding Chronic Kidney Disease Self-Management Barriers and Facilitators: A Consumer-Led Qualitative Study".Journal of renal care · 2026Article
- Guidelines vs. generative AI in CKD patient education: the role of prompt engineering and expert blinded evaluation.BMC nephrology · 2026Article
- Reframing kidney care: toward whole person, integrative, and minimally disruptive healthcare delivery.BMC nephrology · 2026Article
- Deprivation and limitations in daily life in new onset kidney disease: a population study.Clinical kidney journal · 2026Article
- Relationship Between Patient Activation and Quality of Life in HCN1-Related Epilepsy.Juntendo medical journal · 2026Article
- Exploration of treatment burden during transition onto kidney replacement therapy: A longitudinal qualitative study.PloS one · 2026Article
- An Integrated, Evidence-Guided Framework for Chronic Kidney Disease Self-Management: Behavioral Mechanisms, Implementation Strategies, and Real-World Application.Kidney & blood pressure research · 2026Review
- Patient Activation Impacts Exercise in Older Adults With Kidney Disease.Kidney international reports · 2025Article
- The Minimal Clinically Important Difference for the "Patient Activation Measure".Kidney international reports · 2025Article
- A survey on the association between patient activation and quality of life among patients with chronic kidney disease in Japan.Journal of nephrology · 2025Observational
- The effects of a digital health intervention on patient activation in chronic kidney disease.NPJ digital medicine · 2024Article
- Kidney Beam-A Cost-Effective Digital Intervention to Improve Mental Health.Kidney international reports · 2024Article
- The Patient Activation Measure-13 (PAM-13) in an oncology patient population: psychometric properties and dimensionality evaluation.Health and quality of life outcomes · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe knowledge, skills, and confidence to manage one's own health is termed patient activation and can be assessed using the Patient Activation Measure (PAM). This measure is increasingly recommended for use in chronic kidney disease (CKD), but there is a need to better understand patient activation within this population. This work aimed to explore the association of PAM with patient-reported outcomes, namely symptom burden and health-related quality of life (HRQoL), to understand the relationship between patient activation and outcomes which are of importance to people with CKD.
methodsNon-dialysis, dialysis, and kidney transplant patients from 14 renal units across England completed a survey comprising questionnaires assessing patient activation, symptom burden, and HRQoL. Latent class analysis (LCA) was used to determine HRQoL and symptom burden subgroups in the data. Multinomial logistic regression analyses were performed to investigate the associations between patient activation and symptom burden and HRQoL classes separately, adjusting for age, gender, ethnicity, deprivation and treatment modality.
resultsThree thousand thirteen participants (mean age 61.5 years, 61.8% males, and 47% haemodialysis) were included in the analysis. Patient activation was strongly associated with both the HRQoL and symptom burden classes identified, with highly activated patients more likely to report higher HRQoL (P = < 0.0001; OR 29.2, 95% CI 19.5-43.9) and fewer symptoms (P = < 0.0001; OR 25.9, 95% CI 16.8-40.2).
conclusionLower activation levels are associated with a higher symptom burden and reduced HRQoL across the trajectory of CKD stages and treatment modalities. Therefore, targeted and holistic self-management support focussing on improving activation may have the potential to improve aspects of health experience which are valued by individuals living with kidney disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.