ArticleEmerging microbes & infections2022
Aetiology of severe community acquired pneumonia in adults identified by combined detection methods: a multi-centre prospective study in China.
Article in Emerging microbes & infections, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers, 5 of them syntheses that pooled it.
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Who cites it
98 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Efficacy of traditional Chinese medicine in treating severe pneumonia: A meta-analysis and systematic review.Medicine · 2026Pooled it
- Global prevalence of psittacosis in outbreaks: a systematic review and meta-analysis.BMC public health · 2025Pooled it
- Clinical features and prognostic predictors of C. Psittaci Pneumonia: a systematic review and individual patient meta-analysis.BMC pulmonary medicine · 2025Pooled it
- Etiology of bacterial pneumonia and multi-drug resistance pattern among pneumonia suspected patients in Ethiopia: a systematic review and meta-analysis.BMC pulmonary medicine · 2024Pooled it
- Prevalence of atypical pathogens in patients with severe pneumonia: a systematic review and meta-analysis.BMJ open · 2023Pooled it
- Clinical, laboratory, and radiological features of community-acquired pneumonia due toAnnals of medicine · 2026Article
- Rapid diagnosis ofExperimental and therapeutic medicine · 2026Article
- Clinical characteristics of Chlamydia psittaci pneumonia diagnosed by next-generation sequencing: An observational study.Medicine · 2026Observational
- Computed tomography findings and severity scores in Chlamydia psittaci pneumonia: a retrospective study of 69 cases with clinical correlation.BMC infectious diseases · 2026Article
- Targeted next-generation sequencing for microbial and clinical diagnosis: a prospective controlled comparison between sputum and bronchoalveolar lavage fluid in patients with community-acquired pneumonia.BMC infectious diseases · 2026Article
- Association of a Hospital-Wide Integrated Stewardship Intervention with Hospital-Acquired Multidrug-Resistant Organism Infection Incidence Density: A Large-Scale Interrupted Time-Series Study.Antibiotics (Basel, Switzerland) · 2026Article
- Clinical characteristics and prognosis of patients with Chlamydia psittaci pneumonia identified by metagenomic next-generation sequencing.BMC infectious diseases · 2026Article
- The impact of the timing of mNGS-guided antibiotic adjustment on clinical outcomes in ICU patients with severe community-acquired pneumonia: a retrospective study.Annals of clinical microbiology and antimicrobials · 2026Article
- Clinical Characteristics of 40 Cases ofInfection and drug resistance · 2026Article
- Comparing differences in onset and clinical manifestations between children and adults withFrontiers in public health · 2026Article
- Clinical management and pharmaceutical care of severeFrontiers in cellular and infection microbiology · 2026Review
- Prognostic value of systemic inflammatory indicators in patients with severe pneumonia.American journal of translational research · 2026Article
- Review
- Targeted Next-Generation Sequencing Reveals Distinct Pathogen Profiles in Community-Acquired Pneumonia Across Age and Disease Severity.Infection and drug resistance · 2026Article
- Clinical characterization ofFrontiers in medicine · 2026Article
38 more citing papers are in PubMed but not listed here.
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Authors and funding
22 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Severe Community Acquired Pneumonia (SCAP) challenges public health globally. Considerable improvements in molecular pathogen testing emerged in the last few years. Our prospective study combinedly used traditional culture, antigen tests, PCR and mNGS in SCAP pathogen identification with clinical outcomes. From June 2018 to December 2019, we conducted a multi-centre prospective study in 17 hospitals of SCAP patients within 48 hours of emergency room stay or hospitalization in China. All clinical data were uploaded into an online database. Blood, urine and respiratory specimens were collected for routine culture, antigen detection, PCR and mNGS as designed appropriately. Aetiology confirmation was made by the local attending physician group and scientific committee according to microbiological results, clinical features, and response to the treatment. Two hundred seventy-five patients were included for final analysis. Combined detection methods made identification rate up to 74.2% (222/299), while 14.4% (43/299) when only using routine cultures and 40.8% (122/299) when not using mNGS. Influenza virus (23.2%, 46/198),
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