Evidence map›Paper›PMID 35081867›Full record

ArticleBioengineered2022

Circular RNA lysophosphatidic acid receptor 3 (circ-LPAR3) enhances the cisplatin resistance of ovarian cancer.

Xuemei Liu, Zhiping Yin, Yanjun Wu, Qian Zhan, Honghong Huang, Jiangtao Fan

Open access · goldAbstract readVideo-Audio Media
In one paragraph

Article in Bioengineered, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 23 citations in OpenAlex.

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  9. Role of circular RNA as competing endogenous RNA in ovarian cancer (Review).International journal of molecular medicine · 2024
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  16. Roles and mechanisms of CircRNAs in ovarian cancer.Frontiers in cell and developmental biology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 1 country.

Xuemei LiuDepartment of Gynaecology and Obstetrics, Jinan City People's Hospital, Jinan, China.
Zhiping YinDepartment of Laboratory Medicine, Yunnan Provincial Hospital of Traditional Chinese Medicine, Kunming, China.
Yanjun WuDepartment of Gynaecology and Obstetrics, Liaocheng People's Hospital, Liaocheng, China.
Qian ZhanDepartment of Laboratory Medicine, Yunnan Provincial Hospital of Traditional Chinese Medicine, Kunming, China.
Honghong HuangDepartment of Pharmacy, Faculty of Chinese Medicine Science, Guangxi University of Chinese Medicine, Nanning, Guangxi, China.ORCID 0000-0001-6741-9664
Jiangtao FanDepartment of Gynecology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Yunnan Provincial Hospital of Traditional Chinese Medicine · CNGuangxi Medical University · CNGuangxi University of Chinese Medicine · CNJinan City People's Hospital · CNLiaocheng People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circular RNA (circRNA) is considered to be an important regulator that mediates cancer chemoresistance. But whether circ-LPAR3 is involved in ovarian cancer (OC) cisplatin (DDP) resistance is unclear. The circ-LPAR3, miR-634 and pyruvate dehydrogenase kinase 1 (PDK1) expression was measured by quantitative real-time PCR (qRT-PCR). Cell cisplatin resistance and viability were measured by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl-tetrazolium bromide (MTT) assay. In addition, cell colony number, apoptosis, and metastasis were assessed by colony formation assay, flow cytometry and transwell assay. Furthermore,

Indexed as

CisplatinDrug Resistance, NeoplasmCell Line, TumorFemaleHumansOvarian NeoplasmsRNA, CircularRNA, NeoplasmCisplatinRNA, CircularRNA, Neoplasmcirc-LPAR3miR-634Ovarian cancerPDK1resistance

Identifiers

PMID35081867
PMCPMC8974081
OpenAlexW4210499755

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.