ArticleJournal of dental research2022
Pathways Linking Oral Bacteria, Nitric Oxide Metabolism, and Health.
Article in Journal of dental research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- The Effect of Chlorhexidine Mouthwash on Blood Pressure: A Systematic Review and Meta-Analysis.International journal of dental hygiene · 2026Pooled it
- Increased Nitrate Intake From Beetroot Juice Over 4 Weeks Changes the Composition of the Oral, But Not the Intestinal Microbiome.Molecular nutrition & food research · 2025Trial
- Probiotics modulate gastrointestinal microbiota afterFrontiers in immunology · 2022Trial
- Unique Oral Microbiota Signatures and Neurocognitive Function in Adolescents with and without Perinatally Acquired HIV.Research square · 2026Article
- The effect of antibacterial mouthwash on blood pressure in humans: a scoping review.BMC cardiovascular disorders · 2026Article
- Review
- Article
- Dysbiosis of oral bacteriome and mycobiome associated with the severity of heart failure.BMC oral health · 2026Article
- Characteristics of the Tongue Coating Microbiome and Its Subtype Differences in Patients with Inflammatory Bowel Disease.Microorganisms · 2026Article
- Dietary Nitrate-Rich Vegetables as Natural Modulators of Health: Mechanisms and Benefits in Ageing Populations.International journal of molecular sciences · 2026Review
- Oral microbiome perturbations link periodontal health to cognitive ageing in a large community cohort.EBioMedicine · 2026Article
- Dietary Nitrate Intake and 16S rRNA-Inferred Nitrite-Generating Capacity of the Subgingival Microbiome May Influence Glucose Metabolism: Results From the Oral Infections Glucose Intolerance and Insulin Resistance Study (ORIGINS).Journal of clinical periodontology · 2026Article
- Article
- Influence of exercise training on nitric oxide pathways and their physiological effects.Redox biology · 2026Review
- The Oral Microbiome and Systemic Health: Current Insights into the Mouth-Body Connection.Life (Basel, Switzerland) · 2026Review
- Evaluating the association between oral microbiota and cardiovascular diseases: evidence from Mendelian randomization analysis.Journal of geriatric cardiology : JGC · 2026Article
- [Differences in Oral and Gut Microbiome Composition Among Preschool Children in Urumqi During the Deciduous and Mixed Dentition Periods].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026Article
- Metagenomic analysis of tongue samples from healthy subjects identifies distinct microbiome orotypes.Journal of oral microbiology · 2026Article
- Unraveling the oral microbiome's role in Alzheimer's disease: From pathophysiology to therapeutic potential.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Relationship Between Periodontitis and Nitric Oxide in Patients Undergoing Maintenance Hemodialysis.Hemodialysis international. International Symposium on Home Hemodialysis · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Nitrate-reducing oral bacteria have gained a lot of interest due to their involvement in nitric oxide (NO) synthesis and its important cardiometabolic outcomes. Consortia of nitrate-metabolizing oral bacteria associated with cardiometabolic health and cognitive function have been recently identified. Longitudinal studies and clinical trials have shown that chronic mouthwash use is associated with increased blood pressure and increased risk for prediabetes/diabetes and hypertension. Concurrently, recent studies are beginning to shed some light on the complexity of nitrate reduction pathways of oral bacteria, such as dissimilatory nitrate reduction to ammonium (DNRA), which converts nitrite into ammonium, and denitrification, which converts nitrite to NO, nitrous oxide, and dinitrogen. These pathways can affect the composition and metabolism of the oral microbiome; consequently, salivary nitrate and nitrite metabolism have been proposed as targets for probiotics and oral health. These pathways could also affect systemic NO levels because NO generated through denitrification can be oxidized back to nitrite in the saliva, thus facilitating flux along the NO
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.