Evidence map›Paper›PMID 35081662›Full record

ArticleThe Journal of physiology2022

Bile acid- and ethanol-mediated activation of Orai1 damages pancreatic ductal secretion in acute pancreatitis.

Petra Pallagi, Marietta Görög, Noémi Papp, Tamara Madácsy, Árpád Varga, Tim Crul, Viktória Szabó, Melinda Molnár, Krisztina Dudás, Anna Grassalkovich and 5 more

Open access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in The Journal of physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 32 citations in OpenAlex.

  1. The Roles of Gut Microbiota in the Pathogenesis of Acute Pancreatitis.Medical science monitor : international medical journal of experimental and clinical research · 2026
    Review
  2. Review
  3. CRAC channels as targets for immunotherapy.Current opinion in immunology · 2026
    Review
  4. Orai1 is required for CabioRxiv : the preprint server for biology · 2026
    Article
  5. Acute pancreatitis: mechanisms and therapeutic approaches.Signal transduction and targeted therapy · 2026
    Review
  6. Targeted therapeutics for pancreatitis.Frontiers in physiology · 2026
    Review
  7. Review
  8. Review
  9. Review
  10. Renalase peptides reduce pancreatitis severity in mice.American journal of physiology. Gastrointestinal and liver physiology · 2024
    Article
  11. Article
  12. The Role of the Gut Microbiome in the Development of Acute Pancreatitis.International journal of molecular sciences · 2024
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. The role of CaCell calcium · 2023
    Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Petra PallagiHCEMM-SZTE Molecular Gastroenterology Research Group, University of Szeged, Szeged, Hungary.
Marietta GörögDepartment of Medicine, University of Szeged, Szeged, Hungary.
Noémi PappDepartment of Medicine, University of Szeged, Szeged, Hungary.
Tamara MadácsyHCEMM-SZTE Molecular Gastroenterology Research Group, University of Szeged, Szeged, Hungary.
Árpád VargaHCEMM-SZTE Molecular Gastroenterology Research Group, University of Szeged, Szeged, Hungary.ORCID 0000-0002-2379-139X
Tim CrulHCEMM-SZTE Molecular Gastroenterology Research Group, University of Szeged, Szeged, Hungary.ORCID 0000-0002-6053-7016
Viktória SzabóHCEMM-SZTE Molecular Gastroenterology Research Group, University of Szeged, Szeged, Hungary.ORCID 0000-0001-6547-9102
Melinda MolnárDepartment of Medicine, University of Szeged, Szeged, Hungary.
Krisztina DudásDepartment of Medicine, University of Szeged, Szeged, Hungary.
Anna GrassalkovichDepartment of Medicine, University of Szeged, Szeged, Hungary.
Edit SzederkényiDepartment of Surgery, University of Szeged, Szeged, Hungary.
György LázárDepartment of Surgery, University of Szeged, Szeged, Hungary.
Viktória VengloveczDepartment of Pharmacology and Pharmacotherapy, University of Szeged, Szeged, Hungary.
Péter HegyiDepartment of Medicine, University of Szeged, Szeged, Hungary.ORCID 0000-0003-0399-7259
József MaléthHCEMM-SZTE Molecular Gastroenterology Research Group, University of Szeged, Szeged, Hungary.
University of Szeged · HUSemmelweis University · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Regardless of its aetiology, sustained intracellular Ca

Indexed as

PancreatitisAcute DiseaseBile Acids and SaltsCalciumCalcium SignalingEthanolHumansORAI1 ProteinStromal Interaction Molecule 1Bile Acids and SaltsCalciumEthanolORAI1 ProteinORAI1 protein, humanStromal Interaction Molecule 1acute pancreatitisbile acidCa2+ signallingepithelial ion transportethanolOrai1 channel

Identifiers

PMID35081662
OpenAlexW4210603220

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.