ArticleInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2022
Analysis of the factors predicting clinical response to tocilizumab therapy in patients with severe COVID-19.
Article in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Does timing of tocilizumab administration affect mortality in COVID-19? A Scottish multicentre retrospective cohort study.BMJ open respiratory research · 2024Observational
- GM-CSF targeting in COVID-19: an approach based on fragile foundations.The European respiratory journal · 2023Article
- Effect of Tocilizumab on Mortality in Patients with SARS-CoV-2 Pneumonia Caused by Delta or Omicron Variants: A Propensity-Matched Analysis in Nimes University Hospital, France.Antibiotics (Basel, Switzerland) · 2023Article
- Infectious Complications After Tocilizumab in Patients with COVID: A Real-World Experience.Journal of community hospital internal medicine perspectives · 2023Article
- Factors predicting poor outcomes of patients treated with tocilizumab for COVID‑19‑associated pneumonia: A retrospective study.Experimental and therapeutic medicine · 2022Article
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30 authors.
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Abstract
backgroundControversy remains about the efficacy of tocilizumab (TCZ) for the treatment of severe COVID-19. We aimed to analyze the profile of TCZ-respondent patients.
methodsWe retrospectively analyzed a cohort of patients with severe COVID-19 who received off-label TCZ after recommendation by a local committee and were admitted to the University Hospital "12 de Octubre" until May 2020. The primary end point was a significant clinical improvement (SCI) on day 14 after administration of TCZ. Factors independently related to SCI were analyzed by multivariate logistic regression models.
resultsOf 428 (63.3%) patients treated with TCZ, 271 (63.3%) experienced SCI. After adjustment for factors related to unfavorable outcomes, TCZ administration within the first 48 hours from admission (odds ratio [OR]: 1.98, 95% confidence Interval [95% CI]: 1.1-3.55; P = 0.02) and ALT levels >100 UI/L at day 0 (OR: 3.28; 95% CI: 1.3-8.1; P = 0.01) were independently related to SCI. The rate of SCI significantly decreased according to the time of TCZ administration: 70.2% in the first 48 hours from admission, 58.5% on days 3-7, and 45.1% after day 7 (P = 0.03 and P = 0.001, respectively).
conclusionTCZ improves the prognosis of patients with COVID-19 the most if treatment starts within the first 48 hours after admission.
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