ArticleImmunity2022
IL-17RA-signaling in Lgr5
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Article in Immunity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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58citing papers in PubMed
13.5field-weighted citation impact, top 1% of its field
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Who cites it
58 citing papers in PubMed, 81 citations in OpenAlex.
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- Gut mucosal barrier: the frontline of bidirectional regulation of the gut-X axis.Medical review (2021) · 2026Review
- Phenotypic Analysis of Mice with Conditional Knockout of PPP2CA in Colonic Tissues.Digestive diseases and sciences · 2026Article
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- Tetrameric STAT5 regulates the formation of immune niche cells to protect stem cell regenerative repair against mucosal inflammation.Experimental & molecular medicine · 2026Article
- Protective Effects of Milk-Derived Extracellular Vesicles on Colitic Mice via ceRNA Network Involving lncRNAs and circRNAs.Foods (Basel, Switzerland) · 2026Article
- Cytokine networks in Paneth cell regulation.Mucosal immunology · 2026Review
- IL-17RA signaling promotes the dedifferentiation of Paneth progenitors through ADAM17 to regenerate gut epithelium post-irradiation.Nature communications · 2026Article
- Intestinal organoid screen reveals that Bacillus velezensis PGM541 promotes epithelial proliferation via its metabolite butyric acid.Microbiome · 2026Article
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- Citraconic acid mitigates radiation-induced intestinal injury by modulating IL-17 signaling to enhance epithelial regeneration.BMC gastroenterology · 2026Article
- The Intestinal Barrier: A Multilayered Gatekeeper Against Systemic Disease.International journal of microbiology · 2026Review
- From mucus secretion to immune surveillance: the evolving roles of goblet cells in intestinal homeostasis and inflammation.Frontiers in immunology · 2026Review
- Intestinal stem cells as innate immune sentinels: coupling environmental sensing to epithelial adaptation.Frontiers in immunology · 2026Review
- IL-17a induces age-related olfactory dysfunction by impairing regeneration and promoting respiratory metaplasia in mice.Nature communications · 2025Article
- Neuroepithelial VIP-VIPR1 interactions differentially control enteric type 1 and type 2 immunity.Nature immunology · 2025Article
- Crosstalk between the circadian clock, intestinal stem cell niche, and epithelial cell fate decision.Genes & diseases · 2025Review
- Intestinal barrier in chronic gut and liver diseases: Pathogenesis and therapeutic targets.Acta pharmaceutica Sinica. B · 2025Review
Corrections and comments
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Authors and funding
29 authors at 10 institutions in 2 countries.
Xun LinDepartment of Microbiology and Immunology, Stony Brook University, Stony Brook, NY, USA.
Stephen J GaudinoDepartment of Microbiology and Immunology, Stony Brook University, Stony Brook, NY, USA.
Kyung Ku JangKimmel Center for Biology and Medicine at the Skirball Institute, New York University Grossman School of Medicine, New York, NY, USA.
Tej BahadurDepartment of Microbiology and Immunology, Stony Brook University, Stony Brook, NY, USA.
Ankita SinghDepartment of Microbiology and Immunology, Stony Brook University, Stony Brook, NY, USA.
Anirban BanerjeeDepartment of Microbiology and Immunology, Stony Brook University, Stony Brook, NY, USA.
Michael BeaupreDepartment of Microbiology and Immunology, Stony Brook University, Stony Brook, NY, USA.
Timothy ChuDepartment of Microbiology and Immunology, Stony Brook University, Stony Brook, NY, USA.
Hoi Tong WongDepartment of Microbiology and Immunology, Stony Brook University, Stony Brook, NY, USA.
Chang-Kyung KimDepartment of Medicine, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA.
Cody KempenDepartment of Microbiology and Immunology, Stony Brook University, Stony Brook, NY, USA.
Jordan AxelradDivision of Gastroenterology and Hepatology, Department of Medicine, New York University Grossman School of Medicine, New York, NY 10016, USA.
Huakang HuangDepartment of Microbiology and Immunology, Stony Brook University, Stony Brook, NY, USA.
Saba KhalidDepartment of Microbiology and Immunology, Stony Brook University, Stony Brook, NY, USA.
Vyom ShahCold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
Onur EskiocakCold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
Olivia B ParksUniversity of Pittsburgh School of Medicine, Medical Scientist Training Program, Pittsburgh, PA 15213, USA.
Artan BerishaDepartment of Microbiology and Immunology, Stony Brook University, Stony Brook, NY, USA.
Jeremy P McAleerDepartment of Pharmaceutical Science, Marshall University School of Pharmacy, Huntington, WV 25701, USA.
Misty GoodWashington University School of Medicine, Department of Pediatrics, Division of Newborn Medicine, St. Louis Children's Hospital, St. Louis, MO 63110, USA.
Miko HoshinoDepartment of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187-8502, Japan.
Richard BlumbergDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Agnieszka B BialkowskaDepartment of Medicine, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA.
Sarah L GaffenDivision of Rheumatology and Clinical Immunology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Jay K KollsCenter for Translational Research in Infection and Inflammation, Tulane School of Medicine, New Orleans, LA 70112, USA.
Vincent W YangDepartment of Medicine, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA.
Semir BeyazCold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
Ken CadwellKimmel Center for Biology and Medicine at the Skirball Institute, New York University Grossman School of Medicine, New York, NY, USA; Division of Gastroenterology and Hepatology, Department of Medicine, New York University Grossman School of Medicine, New York, NY 10016, USA; Department of Microbiology, New York University Grossman School of Medicine, New York, NY 10016, USA. Electronic address: ken.cadwell@med.nyu.edu.
Pawan KumarDepartment of Microbiology and Immunology, Stony Brook University, Stony Brook, NY, USA. Electronic address: pawan.kumar@stonybrook.edu.
Stony Brook University · USCold Spring Harbor Laboratory · USNew York University · USStony Brook School · USUniversity of Pittsburgh · USBrigham and Women's Hospital · USMarshall University · USNational Center of Neurology and Psychiatry · JPSt. Louis Children's Hospital · USTulane University · US
Funding
Single-Cell Biology Shared ResourceP30CA045508 · NCI · COLD SPRING HARBOR LABORATORY · PI John Edward Moses · 1987 to 2026
$118.9MProject-005UL1TR001445 · NCATS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BREDELLA, MIRIAM ANTOINETTE, HOCHMAN, JUDITH S · 2015 to 2025
$103.5MVaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ANIRBAN MAITRA · 1985 to 2026
$83.1MEndoplasmic reticulum stress and intestinal inflammationR01DK088199 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI Richard S Blumberg · 2010 to 2026
$9.6MREGULATION OF INTESTINAL EPITHELIAL CELL PROLIFERATIONR01DK052230 · NIDDK · STATE UNIVERSITY NEW YORK STONY BROOK · PI Vincent W Yang · 1997 to 2026
$8.7MDiabetes, Digestive, and Kidney Diseases Extramural ResearchR01DK093668 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI Ken Hashigiwa Cadwell · 2011 to 2026
$7.3MTraining in CD4 T-cell Lung ImmunityR35HL139930 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI KOLLS, JAY K · 2018 to 2024
$6.3MHost and Fungal Regulation of Type 17 Immunity to Oral CandidiasisR37DE022550 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Sarah L Gaffen · 2017 to 2026
$5.6MRedefining the role of autophagy in bacterial diseaseR01AI121244 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Ken Hashigiwa Cadwell · 2017 to 2026
$5.6MThe role of autophagy gene Atg16L1 in allogeneic hematopoietic stem cell transplantation - Resubmission - 1R01HL123340 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CADWELL, KEN HASHIGIWA, VAN DEN BRINK, MARCEL R M · 2015 to 2022
$5.2MImproved Therapeutics and Diagnostics for PneumocystisPneumoniaR01AI120033 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JAY K KOLLS · 2016 to 2026
$4.8MMOLECULAR AND CELL BIOLOGY OF INFECTIOUS DISEASEST32AI007539 · NIAID · STATE UNIVERSITY NEW YORK STONY BROOK · PI KONOPKA, JAMES B · 1998 to 2023
$3.6MNCATS NIH HHS UL1 TR001445NCI NIH HHS P30 CA016087NCI NIH HHS P30 CA045508NHLBI NIH HHS R01 HL123340NHLBI NIH HHS R01 HL125816NHLBI NIH HHS R35 HL139930NIAID NIH HHS R01 AI120033NIAID NIH HHS R01 AI121244NIAID NIH HHS R01 AI130945NIAID NIH HHS R01 AI140754NIAID NIH HHS R21 AI149257NIAID NIH HHS T32 AI007539NIDCR NIH HHS R01 DE022550NIDCR NIH HHS R37 DE022550NIDDK NIH HHS R01 DK052230NIDDK NIH HHS R01 DK088199NIDDK NIH HHS R01 DK093668NIDDK NIH HHS R01 DK103788NIDDK NIH HHS R01 DK121798NIDDK NIH HHS R01 DK124336
Abstract
The Th17 cell-lineage-defining cytokine IL-17A contributes to host defense and inflammatory disease by coordinating multicellular immune responses. The IL-17 receptor (IL-17RA) is expressed by diverse intestinal cell types, and therapies targeting IL-17A induce adverse intestinal events, suggesting additional tissue-specific functions. Here, we used multiple conditional deletion models to identify a role for IL-17A in secretory epithelial cell differentiation in the gut. Paneth, tuft, goblet, and enteroendocrine cell numbers were dependent on IL-17A-mediated induction of the transcription factor ATOH1 in Lgr5
Indexed as
AnimalsBasic Helix-Loop-Helix ProteinsCell CommunicationCell DifferentiationCell LineageColitisDextran SulfateHumansInterleukin-17Intestinal MucosaIntestinesMiceMice, KnockoutNF-kappa BReceptors, G-Protein-CoupledReceptors, Interleukin-17Atoh1 protein, mouseBasic Helix-Loop-Helix ProteinsDextran SulfateIl17a protein, mouseIl17ra protein, mouseInterleukin-17Lgr5 protein, mouseNF-kappa BReceptors, G-Protein-CoupledReceptors, Interleukin-17Sox9 protein, mouseSOX9 Transcription FactorATOH1IL-17AintestineLgr5organoidsprogenitor cellssecretory cell lineagestem cellTh17
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