Evidence map›Paper›PMID 35081007›Full record

ArticleAmerican journal of respiratory and critical care medicine2022

Epigenetic Modification of the von Willebrand Factor Promoter Drives Platelet Aggregation on the Pulmonary Endothelium in Chronic Thromboembolic Pulmonary Hypertension.

Xue D Manz, Robert Szulcek, Xiaoke Pan, Petr Symersky, Chris Dickhoff, Jisca Majolée, Veerle Kremer, Elisabetta Michielon, Ekaterina S Jordanova, Teodora Radonic and 11 more

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In one paragraph

Article in American journal of respiratory and critical care medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
8.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 57 citations in OpenAlex.

  1. Review
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  3. Article
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  6. Review
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  8. Rare variants inERJ open research · 2025
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  11. Article
  12. Review
  13. Article
  14. Chronic thromboembolic pulmonary disease.The European respiratory journal · 2024
    Review
  15. Article
  16. Article
  17. When a DEAD-Box Protein Is the Key: A Novel Role for DDX5 in Lung Pericyte Dysfunction.American journal of respiratory cell and molecular biology · 2024
    Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors at 6 institutions in 3 countries.

Xue D ManzDepartment of Pulmonary Medicine and.
Robert SzulcekDepartment of Pulmonary Medicine and.
Xiaoke PanDepartment of Pulmonary Medicine and.
Petr SymerskyDepartment of Cardio-thoracic Surgery.
Chris DickhoffDepartment of Cardio-thoracic Surgery.
Jisca MajoléeDepartment of Physiology, Amsterdam University Medical Center, Vrije Universiteit University Medical Center, Amsterdam Cardiovascular Sciences, Amsterdam, the Netherlands.
Veerle KremerDepartment of Physiology, Amsterdam University Medical Center, Vrije Universiteit University Medical Center, Amsterdam Cardiovascular Sciences, Amsterdam, the Netherlands.
Elisabetta MichielonDepartment of Molecular Cell Biology and Immunology, and.
Ekaterina S JordanovaCenter for Gynecologic Oncology Amsterdam, and.
Teodora RadonicDepartment of Pathology, Amsterdam UMC, VU University Medical Center, Amsterdam, the Netherlands.
Irene V BijnsdorpDepartment of Medical Oncology, Amsterdam UMC, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, the Netherlands; and.
Sander R PiersmaDepartment of Medical Oncology, Amsterdam UMC, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, the Netherlands; and.
Thang V PhamDepartment of Medical Oncology, Amsterdam UMC, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, the Netherlands; and.
Connie R JimenezDepartment of Medical Oncology, Amsterdam UMC, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, the Netherlands; and.
Anton Vonk NoordegraafDepartment of Pulmonary Medicine and.
Frances S de ManDepartment of Pulmonary Medicine and.
Reinier A BoonDepartment of Physiology, Amsterdam University Medical Center, Vrije Universiteit University Medical Center, Amsterdam Cardiovascular Sciences, Amsterdam, the Netherlands.
Jan VoorbergDepartment of Molecular Hematology, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, Academic Medical Center, Amsterdam, the Netherlands.
Peter L HordijkDepartment of Physiology, Amsterdam University Medical Center, Vrije Universiteit University Medical Center, Amsterdam Cardiovascular Sciences, Amsterdam, the Netherlands.
Jurjan AmanDepartment of Pulmonary Medicine and.
Harm Jan BogaardDepartment of Pulmonary Medicine and.
Amsterdam University Medical Centers · NLCancer Center Amsterdam · NLAmsterdam UMC Location University of Amsterdam · NLAmsterdam UMC Location Vrije Universiteit Amsterdam · NLGynecologic Oncology Group · USHumboldt-Universität zu Berlin · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Hypertension, Pulmonaryvon Willebrand FactorEndothelial CellsEndothelium, VascularEpigenesis, GeneticHumansPlatelet AggregationProteomicsvon Willebrand Factorchronic thromboembolic pulmonary hypertensionendothelial cellsepigeneticsnuclear factor κBvon Willebrand factor

Identifiers

PMID35081007
OpenAlexW4210314404

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.