ArticleScience advances2022
Substrate-bound and substrate-free outward-facing structures of a multidrug ABC exporter.
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Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
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Who cites it
22 citing papers in PubMed, 52 citations in OpenAlex.
- Lactate metabolism and protein lactylation in programmed cell death: From novel mechanism to therapeutic strategies in human diseases.Clinical and translational medicine · 2026Review
- ATP-driven conformational dynamics reveal hidden intermediates in a heterodimeric ABC transporter.eLife · 2026Article
- The Antidepressant Drug Clomipramine Inhibits the ABC Transporter BmrA.Chembiochem : a European journal of chemical biology · 2026Article
- Overcoming divalent cation sensitivity is not the only challenge for functional study of ABC transporters within polymer lipid particles.Bioscience reports · 2026Article
- Drug-bound outward-facing conformation of a heterodimeric ABC exporter suggests a putative mechanism of drug translocation.Nature communications · 2025Article
- Bidirectional communication between nucleotide and substrate binding sites in a type IV multidrug ABC transporter.Nature communications · 2025Article
- X-ray diffraction images for two membrane protein crystals presenting high anisotropy; theIUCrData · 2025Article
- Rhodamine6G and Hœchst33342 narrow BmrA conformational spectrum for a more efficient use of ATP.Nature communications · 2025Article
- 3D variability analysis reveals a hidden conformational change controlling ammonia transport in human asparagine synthetase.Nature communications · 2024Article
- 3D Variability Analysis Reveals a Hidden Conformational Change Controlling Ammonia Transport in Human Asparagine Synthetase.bioRxiv : the preprint server for biology · 2024Article
- Conformational dynamics underlying atypical chemokine receptor 3 activation.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Article
- Genome wide structural prediction of ABC transporter systems inFrontiers in microbiology · 2024Article
- The transport activity of the multidrug ABC transporter BmrA does not require a wide separation of the nucleotide-binding domains.The Journal of biological chemistry · 2024Article
- Hydrogen/deuterium exchange-mass spectrometry of integral membrane proteins in native-like environments: current scenario and the way forward.Essays in biochemistry · 2023Article
- Unfolding Individual Domains of BmrA, a Bacterial ABC Transporter Involved in Multidrug Resistance.International journal of molecular sciences · 2023Article
- The Switch and Reciprocating Models for the Function of ABC Multidrug Exporters: Perspectives on Recent Research.International journal of molecular sciences · 2023Review
- Virulence regulation of ZnFrontiers in veterinary science · 2023Article
- Solid-State NMR Reveals Asymmetric ATP Hydrolysis in the Multidrug ABC Transporter BmrA.Journal of the American Chemical Society · 2022Article
- Backbone NMR assignment of the nucleotide binding domain of the Bacillus subtilis ABC multidrug transporter BmrA in the post-hydrolysis state.Biomolecular NMR assignments · 2022Article
Corrections and comments
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Authors and funding
20 authors at 4 institutions in 2 countries.
Vincent ChaptalDrug Resistance and Membrane Proteins Group, Molecular Microbiology and Structural Biochemistry Laboratory, CNRS UMR 5086, University of Lyon, IBCP, 7, passage du Vercors, 69367 Lyon, France.ORCID 0000-0003-2603-0294
Veronica ZampieriDrug Resistance and Membrane Proteins Group, Molecular Microbiology and Structural Biochemistry Laboratory, CNRS UMR 5086, University of Lyon, IBCP, 7, passage du Vercors, 69367 Lyon, France.ORCID 0000-0002-8292-2951
Benjamin WisemanDrug Resistance and Membrane Proteins Group, Molecular Microbiology and Structural Biochemistry Laboratory, CNRS UMR 5086, University of Lyon, IBCP, 7, passage du Vercors, 69367 Lyon, France.ORCID 0000-0002-2994-5839
Cédric OrelleBacterial Nucleotide-Binding Proteins Group, Molecular Microbiology and Structural Biochemistry Laboratory, CNRS UMR 5086, University of Lyon, IBCP, 7, passage du Vercors, 69367 Lyon, France.ORCID 0000-0003-3418-3290
Juliette MartinModeling Biological Macromolecules Group, Molecular Microbiology and Structural Biochemistry Laboratory, CNRS UMR 5086, University of Lyon, IBCP, 7, passage du Vercors, 69367 Lyon, France.ORCID 0000-0002-4787-0885
Kim-Anh NguyenUniversity of Grenoble Alpes, INSERM, LRB, 38000 Grenoble, France.ORCID 0000-0001-5143-507X
Alexia GobetDrug Resistance and Membrane Proteins Group, Molecular Microbiology and Structural Biochemistry Laboratory, CNRS UMR 5086, University of Lyon, IBCP, 7, passage du Vercors, 69367 Lyon, France.
Margot Di CesareBacterial Nucleotide-Binding Proteins Group, Molecular Microbiology and Structural Biochemistry Laboratory, CNRS UMR 5086, University of Lyon, IBCP, 7, passage du Vercors, 69367 Lyon, France.ORCID 0000-0002-7883-852X
Sandrine MagnardDrug Resistance and Membrane Proteins Group, Molecular Microbiology and Structural Biochemistry Laboratory, CNRS UMR 5086, University of Lyon, IBCP, 7, passage du Vercors, 69367 Lyon, France.ORCID 0000-0003-1195-1840
Waqas JavedBacterial Nucleotide-Binding Proteins Group, Molecular Microbiology and Structural Biochemistry Laboratory, CNRS UMR 5086, University of Lyon, IBCP, 7, passage du Vercors, 69367 Lyon, France.ORCID 0000-0002-3381-4794
Jad EidDrug Resistance and Membrane Proteins Group, Molecular Microbiology and Structural Biochemistry Laboratory, CNRS UMR 5086, University of Lyon, IBCP, 7, passage du Vercors, 69367 Lyon, France.
Arnaud KilburgDrug Resistance and Membrane Proteins Group, Molecular Microbiology and Structural Biochemistry Laboratory, CNRS UMR 5086, University of Lyon, IBCP, 7, passage du Vercors, 69367 Lyon, France.ORCID 0000-0003-4803-6232
Marine PeuchmaurUniversity of Grenoble Alpes, CNRS, DPM UMR 5063, 38041 Grenoble, France.
Julien MarcouxInstitut de Pharmacologie et de Biologie Structurale (IPBS), UMR 5089, Université de Toulouse, CNRS, UPS, 31000 Toulouse, France.ORCID 0000-0001-7321-7436
Luca MonticelliModeling Biological Macromolecules Group, Molecular Microbiology and Structural Biochemistry Laboratory, CNRS UMR 5086, University of Lyon, IBCP, 7, passage du Vercors, 69367 Lyon, France.ORCID 0000-0002-6352-4595
Martin HogbomDepartment of Biochemistry and Biophysics, Arrhenius Laboratories for Natural Sciences, Stockholm University, Stockholm, Sweden.ORCID 0000-0001-5574-9383
Guy SchoehnUniversity of Grenoble Alpes, CEA, CNRS, IBS, F-38000 Grenoble, France.ORCID 0000-0002-1459-3201
Jean-Michel JaultBacterial Nucleotide-Binding Proteins Group, Molecular Microbiology and Structural Biochemistry Laboratory, CNRS UMR 5086, University of Lyon, IBCP, 7, passage du Vercors, 69367 Lyon, France.ORCID 0000-0003-1743-2777
Ahcène BoumendjelUniversity of Grenoble Alpes, INSERM, LRB, 38000 Grenoble, France.
Pierre FalsonDrug Resistance and Membrane Proteins Group, Molecular Microbiology and Structural Biochemistry Laboratory, CNRS UMR 5086, University of Lyon, IBCP, 7, passage du Vercors, 69367 Lyon, France.ORCID 0000-0002-9760-4577
Université Claude Bernard Lyon 1 · FRCentre National de la Recherche Scientifique · FRInserm · FRStockholm University · SE
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multidrug ABC transporters translocate drugs across membranes by a mechanism for which the molecular features of drug release are so far unknown. Here, we resolved three ATP-Mg
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