Evidence map›Paper›PMID 35080970›Full record

ArticleScience advances2022

Identification of shared tumor epitopes from endogenous retroviruses inducing high-avidity cytotoxic T cells for cancer immunotherapy.

Paola Bonaventura, Vincent Alcazer, Virginie Mutez, Laurie Tonon, Juliette Martin, Nicolas Chuvin, Emilie Michel, Rasha E Boulos, Yann Estornes, Jenny Valladeau-Guilemond and 4 more

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 96 citations in OpenAlex.

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  17. Revisiting Clonal Evolution Through the Light of Retrotransposons.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
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15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Paola BonaventuraCentre de Recherche en Cancérologie de Lyon (CRCL), UMR INSERM U1052 CNRS 5286, Lyon, France.ORCID 0000-0002-5774-3310
Vincent AlcazerCentre de Recherche en Cancérologie de Lyon (CRCL), UMR INSERM U1052 CNRS 5286, Lyon, France.ORCID 0000-0003-1843-6286
Virginie MutezErVaccine Technologies, Lyon, France.ORCID 0000-0001-5727-4836
Laurie TononSynergie Lyon Cancer, Plateforme de bioinformatique « Gilles Thomas », Lyon, France.
Juliette MartinCNRS-Institut de Biologie et Chimie des Protéines UMR 5086, Lyon, France.ORCID 0000-0002-4787-0885
Nicolas ChuvinErVaccine Technologies, Lyon, France.ORCID 0000-0002-2138-2330
Emilie MichelErVaccine Technologies, Lyon, France.ORCID 0000-0002-5359-2623
Rasha E BoulosErVaccine Technologies, Lyon, France.ORCID 0000-0003-1607-2394
Yann EstornesErVaccine Technologies, Lyon, France.ORCID 0000-0003-2687-290X
Jenny Valladeau-GuilemondCentre de Recherche en Cancérologie de Lyon (CRCL), UMR INSERM U1052 CNRS 5286, Lyon, France.
Alain ViariSynergie Lyon Cancer, Plateforme de bioinformatique « Gilles Thomas », Lyon, France.ORCID 0000-0002-1329-7777
Qing WangComplete Omics, Baltimore, MD, USA.ORCID 0000-0002-7979-766X
Christophe CauxCentre de Recherche en Cancérologie de Lyon (CRCL), UMR INSERM U1052 CNRS 5286, Lyon, France.ORCID 0000-0003-2438-833X
Stéphane DepilCentre de Recherche en Cancérologie de Lyon (CRCL), UMR INSERM U1052 CNRS 5286, Lyon, France.ORCID 0000-0001-6011-3945
Centre National de la Recherche Scientifique · FRCentre de Recherche en Cancérologie de Lyon · FRUniversité Claude Bernard Lyon 1 · FRComplete Omics (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human endogenous retroviruses (HERVs) represent 8% of the human genome. HERV products may represent tumor antigens relevant for cancer immunotherapy. We developed a bioinformatic approach to identify shared CD8

Indexed as

Breast NeoplasmsEndogenous RetrovirusesCD8-Positive T-LymphocytesEpitopes, T-LymphocyteFemaleHLA-A2 AntigenHumansImmunotherapyEpitopes, T-LymphocyteHLA-A2 Antigen

Identifiers

PMID35080970
PMCPMC8791462
OpenAlexW4226063992

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.