Evidence map›Paper›PMID 35080969›Full record

ArticleScience advances2022

Acute multidrug delivery via a wearable bioreactor facilitates long-term limb regeneration and functional recovery in adult

Nirosha J Murugan, Hannah J Vigran, Kelsie A Miller, Annie Golding, Quang L Pham, Megan M Sperry, Cody Rasmussen-Ivey, Anna W Kane, David L Kaplan, Michael Levin

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 55 citations in OpenAlex.

  1. Review
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  12. Biophysical control of plasticity and patterning in regeneration and cancer.Cellular and molecular life sciences : CMLS · 2023
    Review
  13. Review
  14. Article
  15. Article
  16. Mammalian organ regeneration in spiny mice.Journal of muscle research and cell motility · 2023
    Review
  17. Regenerative engineering of long bones using the small molecule forskolin.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Nirosha J MuruganDepartment of Biology, Tufts University, Medford, MA, USA.ORCID 0000-0001-7260-9956
Hannah J VigranDepartment of Biology, Tufts University, Medford, MA, USA.ORCID 0000-0001-5281-1807
Kelsie A MillerDepartment of Biology, Tufts University, Medford, MA, USA.ORCID 0000-0001-6403-9690
Annie GoldingAllen Discovery Center at Tufts University, Medford, MA, USA.ORCID 0000-0002-1721-7025
Quang L PhamAllen Discovery Center at Tufts University, Medford, MA, USA.ORCID 0000-0003-4010-5408
Megan M SperryDepartment of Biology, Tufts University, Medford, MA, USA.ORCID 0000-0001-8310-5358
Cody Rasmussen-IveyDepartment of Biology, Tufts University, Medford, MA, USA.
Anna W KaneDepartment of Biology, Tufts University, Medford, MA, USA.
David L KaplanAllen Discovery Center at Tufts University, Medford, MA, USA.ORCID 0000-0002-9245-7774
Michael LevinDepartment of Biology, Tufts University, Medford, MA, USA.ORCID 0000-0001-7292-8084
Tufts University · US

Funding

Tissue Engineering Resource Center: TTDP41EB027062 · NIBIB · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Gordana Vunjak-Novakovic · 2019 to 2026
$12.6M
Electrotherapeutic strategies for connective tissue repairR01AR061988 · NIAMS · TUFTS UNIVERSITY MEDFORD · PI HUNG, CLARK T., KAPLAN, DAVID L. · 2011 to 2015
$3.3M
Tissue Regeneration by Biophysical SignalingR01AR055993 · NIAMS · TUFTS UNIVERSITY MEDFORD · PI KAPLAN, DAVID L., LEVIN, MICHAEL · 2010 to 2018
$3.2M
NIAMS NIH HHS R01 AR005593NIAMS NIH HHS R01 AR055993NIBIB NIH HHS P41 EB027062
6 · The paper itself

Abstract

Limb regeneration is a frontier in biomedical science. Identifying triggers of innate morphogenetic responses in vivo to induce the growth of healthy patterned tissue would address the needs of millions of patients, from diabetics to victims of trauma. Organisms such as

Indexed as

BioreactorsWearable Electronic DevicesAdultAnimalsHindlimbHumansMorphogenesisXenopus laevis

Identifiers

PMID35080969
PMCPMC8791464
OpenAlexW4210310689

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.