Evidence map›Paper›PMID 35080921›Full record

ArticleAmerican journal of physiology. Cell physiology2022

Chloride channels with ClC-1-like properties differentially regulate the excitability of dopamine receptor D1- and D2-expressing striatal medium spiny neurons.

Viktor Yarotskyy, Arianna R S Lark, Sara R Nass, Yun K Hahn, Michael G Marone, A Rory McQuiston, Pamela E Knapp, Kurt F Hauser

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Cell physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 5 citations in OpenAlex.

  1. Anoctamin 2 deletion alters dopamine-related signaling and impairs inhibitory behavioral control in mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Novel voltage-dependent ClNeuroscience letters · 2025
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Viktor YarotskyyDepartment of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, Richmond, Virginia.
Arianna R S LarkDepartment of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, Richmond, Virginia.
Sara R NassDepartment of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, Richmond, Virginia.
Yun K HahnDepartment of Anatomy and Neurobiology, School of Medicine, Virginia Commonwealth University, Richmond, Virginia.
Michael G MaroneDepartment of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, Richmond, Virginia.
A Rory McQuistonDepartment of Anatomy and Neurobiology, School of Medicine, Virginia Commonwealth University, Richmond, Virginia.
Pamela E KnappDepartment of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, Richmond, Virginia.
Kurt F HauserDepartment of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, Richmond, Virginia.ORCID 0000-0001-7886-0332
Virginia Commonwealth University · US

Funding

VCU Center for Drug Addiction ResearchP30DA033934 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI Matthew Sean Halquist · 2014 to 2026
$13.8M
MOR and CCR5 interactive signaling mediates opiate and HIV-driven synaptodendritic injuryR01DA034231 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI HAUSER, KURT F, KNAPP, PAMELA E · 2013 to 2023
$5.4M
Mechanisms of Opiate Drug-HIV-Induced NeurodegenerationR01DA018633 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI HAUSER, KURT F · 2005 to 2021
$4.4M
Selective vulnerability of discrete neural circuits in the striatum to HIV-opiate comorbidityR01DA045588 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI HAUSER, KURT F · 2018 to 2022
$2.0M
Cells, synapses, and networks contributing to synchrony in the CNSR01MH107507 · NIMH · VIRGINIA COMMONWEALTH UNIVERSITY · PI MCQUISTON, ADAM RORY · 2016 to 2020
$1.9M
HIV and opiate interactions in behavioral and anterior cingulate cortex synaptic dysfunctionF32DA053163 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI NASS, SARA · 2021 to 2022
$140k
NIDA NIH HHS F32 DA053163NIDA NIH HHS P30 DA033934NIDA NIH HHS R01 DA018633NIDA NIH HHS R01 DA034231NIDA NIH HHS R01 DA045588NIMH NIH HHS R01 MH107507
6 · The paper itself

Abstract

Dynamic chloride (Cl

Indexed as

ChloridesCorpus StriatumChloride ChannelsNeuronsPatch-Clamp TechniquesPhloretinReceptors, Dopamine D2Chloride ChannelsChloridesPhloretinReceptors, Dopamine D2chloride homeostasisClC-1, chloride voltage-gated channel 1dopamine type 1 and type 2 receptorsstriatal medium spiny neuronsTMEM16A, transmembrane protein 16A (Ano1)

Identifiers

PMID35080921
PMCPMC8917939
OpenAlexW4210294101

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.