Evidence map›Paper›PMID 35080857›Full record

ArticleBiochemistry2022

A Disulfide-Stabilized Aβ that Forms Dimers but Does Not Form Fibrils.

Sheng Zhang, Stan Yoo, Dalton T Snyder, Benjamin B Katz, Amy Henrickson, Borries Demeler, Vicki H Wysocki, Adam G Kreutzer, James S Nowick

Abstract read
In one paragraph

Article in Biochemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Probing differences among Aβ oligomers with two triangular trimers derived from Aβ.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sheng ZhangDepartment of Chemistry, University of California Irvine, Irvine, California 92697-2025, United States.ORCID 0000-0002-2105-0627
Stan YooDepartment of Chemistry, University of California Irvine, Irvine, California 92697-2025, United States.ORCID 0000-0002-8982-7631
Dalton T SnyderResource for Native Mass Spectrometry Guided Structural Biology, The Ohio State University, Columbus, Ohio 43210, United States.ORCID 0000-0003-2154-5002
Benjamin B KatzDepartment of Chemistry, University of California Irvine, Irvine, California 92697-2025, United States.
Amy HenricksonDepartment of Chemistry and Biochemistry, University of Lethbridge, 4401 University Dr., Lethbridge, Alberta T1K 3M4, Canada.ORCID 0000-0003-3266-5202
Borries DemelerDepartment of Chemistry and Biochemistry, University of Lethbridge, 4401 University Dr., Lethbridge, Alberta T1K 3M4, Canada.ORCID 0000-0002-2414-9518
Vicki H WysockiResource for Native Mass Spectrometry Guided Structural Biology, The Ohio State University, Columbus, Ohio 43210, United States.ORCID 0000-0003-0495-2538
Adam G KreutzerDepartment of Chemistry, University of California Irvine, Irvine, California 92697-2025, United States.ORCID 0000-0002-9724-6298
James S NowickDepartment of Chemistry, University of California Irvine, Irvine, California 92697-2025, United States.ORCID 0000-0002-2273-1029

Funding

Waters Select Series Cyclic IMS for P41 Native MS Resource Application to Alzheimer's DiseaseP41GM128577 · NIGMS · OHIO STATE UNIVERSITY · PI WYSOCKI, VICKI H. · 2018 to 2022
$7.6M
Development of an UltraScan Meta-Scheduler for HPC Job SubmissionR01GM120600 · NIGMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Emre H. Brookes, BORRIES DEMELER · 2016 to 2026
$3.6M
Purchase of an Microwave Peptide SynthesizerR01GM097562 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI NOWICK, JAMES S · 2012 to 2019
$2.5M
CHEMICAL MODELS OF PROTEIN BETA SHEET INTERACTIONSR01GM049076 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI NOWICK, JAMES S · 1999 to 2009
$1.7M
Structural and Biological Characterization of Diverse Oligomers Derived from AbetaRF1AG072587 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI NOWICK, JAMES S · 2021 to 2021
$1.4M
Structural and Biological Characterization of Diverse Oligomers Derived from AbetaR01AG072587 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI NOWICK, JAMES S · 2024 to 2025
$994k
NIA NIH HHS R01 AG072587NIA NIH HHS RF1 AG072587NIGMS NIH HHS P41 GM128577NIGMS NIH HHS R01 GM049076NIGMS NIH HHS R01 GM097562
6 · The paper itself

Abstract

Aβ dimers are a basic building block of many larger Aβ oligomers and are among the most neurotoxic and pathologically relevant species in Alzheimer's disease. Homogeneous Aβ dimers are difficult to prepare, characterize, and study because Aβ forms heterogeneous mixtures of oligomers that vary in size and can rapidly aggregate into more stable fibrils. This paper introduces Aβ

Indexed as

Alzheimer DiseaseAmyloidAmyloid beta-PeptidesCircular DichroismDisulfidesHumansHydrogen BondingMicroscopy, Electron, TransmissionModels, MolecularPeptide FragmentsProtein ConformationProtein Conformation, beta-StrandAmyloidAmyloid beta-Peptidesamyloid beta-protein (40-42)DisulfidesPeptide Fragments

Identifiers

PMID35080857
PMCPMC9083094

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.